Enriching the Rhode Island Child Health Study

丰富罗德岛州儿童健康研究

• 批准号: 10200810
• 负责人: Carmen Joseph Marsit
• 金额: $ 33.81万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2022-12-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10200810
• 关键词: Adolescence; Age; Behavioral; Biological; Biological Markers; Birth; Chemicals; Child; Child Health; Childhood; Cohort Studies; Collaborations; Collection; Communities; Data; Data Analyses; Data Collection; Data Set; Development; Disease; Disease Outcome; Enrollment; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Impact; Epidemiologist; Epidemiology; Epigenetic Process; Exposure to; Faculty; Follow-Up Studies; Fostering; Funding; Future; Goals; Grant; Growth; Health; Hospitals; Incentives; Infant; Infrastructure; Intervention; Investigation; Investments; Link; Longterm Follow-up; Maintenance; Massachusetts; Measures; Mediating; Mediator of activation protein; Medical Records; Medical center; Molecular; Molecular Biology; Monoclonal Antibody R24; Mothers; National Institute of Environmental Health Sciences; Newborn Infant; Online Systems; Outcome; Participant; Pathogenesis; Pathway interactions; Peer Review; Placenta; Placental Biology; Population; Predisposition; Psychologist; Public Policy; Publications; Recontacts; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; Resources; Rhode Island; Risk Assessment; Role; Sampling; Scientist; Seminal; Social Behavior; Source; Students; System; Training; United States National Institutes of Health; Variant; Work; cohort; community building; critical period; data resource; data sharing; data sharing networks; disorder risk; early adolescence; early childhood; epigenetic regulation; epigenetic variation; exposed human population; follow-up; genomic data; health goals; improved; infancy; infrastructure development; innovation; method development; middle childhood; neurobehavioral; next generation; novel; offspring; postnatal; prenatal; prenatal environmental exposure; prospective; research and development; research study; social; success; web site

PROJECT SUMMARY/ABSTRACT The proposed project is an R24 infrastructure support grant responsive to RFA-ES-16-004, “Maintain and Enrich Resource Infrastructure for Existing Environmental Epidemiology Cohorts.” We propose to maintain and enrich resource infrastructure for the Rhode Island Children's Health Study (RICHS), a cohort developed to examine the impact of the environment on newborn and early childhood health outcomes with a novel focus on the mechanistic role of placenta molecular function. RICHS is a highly productive cohort resource—data collection and analyses to date have resulted in over 40 peer-reviewed publications, and 3 research project grants since 2008 (R01MH094609, R01ES022223, R01ES025145); RICHS has also served as a resource for the training and independent research development of 21 pre- and postdoctoral students and junior faculty. Data and results from the cohort have contributed to the understanding of the fundamental molecular biology of the placenta, the impact of environmental exposures on placental epigenetic regulation, links between placental epigenetic variation in newborn growth and neurobehavioral outcomes, as well as novel methods development. The RICHS cohort is comprised of 840 mother-offspring pairs from the Rhode Island and Southeastern Massachusetts region enrolled from a single, population-representative medical center. RICHS offspring were studied in infancy, but maintenance funds are needed for longitudinal follow-up. The proposed infrastructure support would facilitate future prospective, longitudinal assessments within this extensively characterized prenatal cohort, including novel child health and disease outcomes, postnatal environmental exposures, as well as novel and repeated measures of molecular mediators and biomarkers during the critical window of susceptibility of childhood and early adolescence. The proposed infrastructure support will also allow extensive resource-sharing of RICHS data with the larger scientific community. The specific goals of this R24 are to: (1) recontact and reconsent all RICHS mother-child pairs to allow for continued and expanded follow-up, (2) develop an innovative website for cohort maintenance and cohort community building, (3) develop a web-based data collection system for ongoing data collection using REDCap, (4) provide ongoing incentives for maintaining participant investment in RICHS, (5) collect medical record, neurodevelopmental measures and biospecimens for future research studies, and (6) develop systems for broad sharing of cohort data with the larger research community. Our study fits with NIEHS goals to identify fundamental shared mechanisms, to consider the totality of human exposures, biological pathways, and disease pathogenesis, to foster collaboration, and to inspire new cadre of environmental health scientists. Ultimately, the proposed RICHS infrastructure support will maximize NIEHS investment in a unique cohort resource to allow for further seminal work from our highly productive research group and broad sharing of data and resources with the scientific community.

项目概要/摘要 拟议项目是一项 R24 基础设施支持赠款，响应 RFA-ES-16-004“维护和 丰富现有环境流行病学群体的资源基础设施。”我们建议 维护和丰富罗德岛儿童健康研究 (RIHS) 的资源基础设施，这是一个队列 旨在检查环境对新生儿和幼儿健康结果的影响 小说重点关注胎盘分子功能的机制作用。 RIHS 是一个高生产力的群体 资源——迄今为止的数据收集和分析已产生 40 多份同行评审出版物，以及 3 自 2008 年以来的研究项目资助（R01MH094609、R01ES022223、R01ES025145）； RICHS 还 为21名博士前和博士后的培训和独立研究发展提供资源 学生和初级教师。该队列的数据和结果有助于理解 胎盘的基础分子生物学，环境暴露对胎盘表观遗传的影响 调节，胎盘表观遗传变异在新生儿生长和神经行为结果之间的联系，如 以及新方法的开发。 RIHS 队列由来自 840 对母子组成 罗德岛州和马萨诸塞州东南部地区从单一的人口代表中报名 医疗中心。 RIHS 后代在婴儿期进行了研究，但纵向研究需要维持资金 后续行动。拟议的基础设施支持将有助于未来的前瞻性纵向评估 在这个具有广泛特征的产前队列中，包括新的儿童健康和疾病结果， 产后环境暴露，以及分子介质的新颖和重复测量 儿童期和青春期早期易感性关键窗口期的生物标志物。拟议的 基础设施支持还将允许与更大的科学领域广泛共享 RIHS 数据资源。 社区。 R24 的具体目标是： (1) 重新联系并重新同意所有 RIHS 母子对 允许持续和扩大的后续行动，(2) 开发一个用于队列维护的创新网站，以及 队列社区建设，(3) 开发一个基于网络的数据收集系统，用于持续的数据收集 REDCap，(4) 提供持续激励以维持参与者对 RIHS 的投资，(5) 收集医疗费用 记录、神经发育测量和生物样本以供未来研究使用，以及 (6) 开发系统 与更大的研究界广泛共享队列数据。我们的研究符合 NIEHS 的目标，即确定 基本的共享机制，考虑人类暴露的总体、生物途径和 疾病发病机制，促进合作，并激励环境健康科学家的新骨干队伍。 最终，拟议的 RIHS 基础设施支持将最大限度地提高 NIEHS 对独特的投资 队列资源，以便我们高产的研究小组和广泛的研究人员能够开展进一步的开创性工作 与科学界共享数据和资源。