HERCULES: Exposome Research Center

HERCULES：暴露研究中心

• 批准号: 9902428
• 负责人: Carmen Joseph Marsit
• 金额: $ 149.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-21 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9902428
• 关键词: Achievement; Analytical Chemistry; Award; Bioinformatics; Biomedical Research; Climate; Clinical; Collaborations; Communication; Communities; Community Outreach; Core Facility; Data; Data Science Core; Development; Discipline; Disease; Environment; Environmental Health; Environmental Risk Factor; Evaluation; Fostering; Funding; Genetic; Genome; Genomics; Goals; Grant; Health; Health Care Research; Health Sciences; Human; Individual; Infrastructure; Institution; Intuition; Leadership; Letters; Machine Learning; Marshal; Mentors; Mission; National Institute of Environmental Health Sciences; Phase; Play; Prevention strategy; Productivity; Public Health; Research; Research Activity; Research Personnel; Research Project Grants; Resolution; Resources; Role; Science; Scientist; Statistical Models; Strategic Planning; Systems Biology; Technology; Toxicology; Translations; Update; Vision; base; career development; catalyst; health science research; improved; innovation; metabolomics; novel; operation; ranpirnase; treatment strategy

PROJECT SUMMARY: HERCULES The vision of the HERCULES P30 is to demonstrably advance the role of environmental health sciences in clinical and public health settings using the platform of the exposome. Healthcare and biomedical research have become increasingly genome-centric. While much of this is due to the impressive achievements in genomics, which have consistently outpaced gains in environmental health, it is our contention that a more persuasive case needs to be made for environmental factors. Science and intuition support the idea that the environment plays just as large of a role as genetics for the majority of diseases. The exposome, which embraces a strategy and scale similar to genomic research, is poised to elevate the environment in discussions of health and disease. We will continue to grow and enhance the environmental health science research portfolio at Emory through cutting-edge technologies and innovative data solutions. We will build upon the superb relationships we have built with the local community and continue to push the mission of NIEHS on campus and across the scientific landscape. Based on the extraordinary progress over our first three years, we propose to retain our theme to use exposome-related concepts and approaches to improve human health. This simple and unifying vision will continue to stimulate discovery, promote collaboration, and enhance communication through the following Specific Aims: Specific Aim 1. To marshal physical and intellectual resources to support exposome-related approaches (high-resolution metabolomics, analytical chemistry, systems biology, machine learning, bioinformatics, high-throughput toxicology, and spatial and temporal statistical models) through cores, pilot funding, mentoring, and research forums. Specific Aim 2. To make major contributions towards exposome and environmental health science research. Specific Aim 3. To provide career development activities around innovative and emerging concepts and approaches related to the exposome. Specific Aim 4. To enhance and expand existing relationships with community partners to resolve environmental health issues in the community using exposome principles. Specific Aim 5. To provide infrastructure and resources to facilitate rapid translation of novel scientific findings into the development of prevention and treatment strategies in humans. Pursuit of HERCULES' aims will advance environmental health sciences within our institutions and in the scientific community.

项目概要：HERCULES HERCULES P30的愿景是在以下方面明显推进环境健康科学的作用： 临床和公共卫生设置使用的平台的问题。医疗保健和生物医学研究 变得越来越以基因组为中心。虽然这在很大程度上要归功于基因组学的巨大成就， 这一直超过了环境健康的进步，我们认为，一个更有说服力的案例， 需要考虑环境因素。科学和直觉都支持环境 就像遗传学对大多数疾病的作用一样大。麻烦，它包含一个战略， 规模类似于基因组研究，准备在健康和疾病的讨论中提升环境。 我们将继续发展和加强环境健康科学研究组合在埃默里大学通过 尖端技术和创新的数据解决方案。我们将建立在我们拥有的极好的关系基础上 建立与当地社区，并继续推动校园和整个科学NIEHS的使命 景观基于我们头三年取得的非凡进展，我们建议保留我们的主题， 使用与疾病相关的概念和方法来改善人类健康。这一简单而统一的愿景将 继续通过以下方式促进发现、促进合作和加强交流 具体目标：具体目标1。调动物质和智力资源，支持与问题有关的 方法（高分辨率代谢组学，分析化学，系统生物学，机器学习， 生物信息学、高通量毒理学以及空间和时间统计模型） 资助、指导和研究论坛。具体目标2。为实现可持续发展做出重大贡献， 环境卫生科学研究。具体目标3。提供职业发展活动， 创新和新出现的概念和方法有关的麻烦。具体目标4。加强和 扩大与社区伙伴的现有关系，以解决社区的环境卫生问题 使用麻烦的原则。具体目标5.提供基础设施和资源以促进快速翻译 将新的科学发现应用于人类预防和治疗策略的发展。追求 HERCULES的目标将在我们的机构和科学领域推进环境健康科学。 社区