Research Training in Translational Gastroenterology and Hepatology

转化胃肠病学和肝病学研究培训

• 批准号: 10626836
• 负责人: SUBRA KUGATHASAN
• 金额: $ 36.5万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10626836
• 关键词: Gastroenterology; Hepatology; Research Training

Project Summary In recent years, major advances in patient care in gastroenterology and hepatology have largely been driven by the application of translationally-oriented research employing animal models and human subjects. Increasingly, cross-pollination of basic and clinical research approaches is producing novel insights into gastrointestinal (GI) and liver biology as well as disease pathogenesis. The over-arching goal of this Training Grant (TG) is to prepare outstanding post-doctoral MD, MD/PhD and PhD researchers for successful and impactful careers in translational gastroenterology and hepatology. The Training Program (TP) emphasizes work at the interface between basic biology and translational medicine in order to fill important gaps in knowledge and develop effective therapeutics. The TP incorporates core goals of embracing diversity, equity and inclusivity at all stages: candidacy outreach, applicant and mentor selection, retention and oversight of trainees, and selected invited speakers. The TP is built upon the strengths of a highly experienced group of 20 NIH-supported trainee-focused mentors (8 from Pediatrics, 9 from Internal Medicine, and 3 from other Departments). The mentor pool consists of 10 of whom are primarily basic researchers, 4 principally clinical researchers, and 6 whose research portfolios are split evenly between basic and clinical research. Since many adult GI and liver diseases have origins in childhood that often continue through life, mentors from both adult and pediatric subspecialties are included. This TG application focuses efforts on enrolling 2 post-doctoral Trainees (MD, MD/PhD or PhD) each year. Trainees develop expertise and provide feedback as digestive health researchers under the oversight and guidance of the TP Executive Committee and mentors, integrating Internal and External Advisory Board input. For those who will benefit from advanced degrees, the TP is incorporates a structured degree program in Masters of Science in Clinical Research or a Certificate Program in Translational Research via the Laney Graduate School/Georgia Clinical and Translational Science Alliance. Mentees benefit from a balanced Scholarship Oversight Committee with basic and translational expertise, coursework for the Responsible Conduct of Research (RCR) training and a mentee-driven Individual Development Plan (IDP). Completion of individualized TP (coursework, mentored research experience, environmental exposure, advice and professional development) within a culture of talks and symposia for education and career development via the Enrichment Program of the TP, provide a rich and lasting springboard for mentees' careers.

项目摘要 近年来，胃肠病学和肝病的患者护理的重大进展在很大程度上是由采用动物模型和人类受试者进行翻译为导向的研究的应用。越来越多的基础研究方法的交叉授粉正在产生对胃肠道（GI）和肝脏生物学以及疾病发病机理的新见解。这项培训补助金（TG）的整个目标是为杰出的博士后医学博士，医学博士/博士学位和博士研究人员准备转化胃肠病学和肝病学的成功和有影响力的职业。培训计划（TP）强调了基本生物学和转化医学之间界面的工作，以填补知识的重要空白并发展有效的治疗疗法。 TP在各个阶段都结合了拥抱多样性，公平和包容性的核心目标：候选人宣传，申请人和导师的选择，保留和对学员的监督以及选定的受邀演讲者。 TP建立在经验丰富的20个由NIH支持的实习生的导师（来自儿科的8名，内科医学中的9名，其他部门的3个）的优势建立。导师池由10名主要是基础研究人员，4位主要是临床研究人员，以及6个研究组合在基础研究和临床研究之间均匀分配。由于许多成年胃肠道和肝病的起源通常是童年时期的，因此包括成人和小儿专科的导师。该TG申请每年将努力重点放在注册2名博士后学员（MD，MD/PHD或PHD）上。在TP执行委员会和导师的监督和指导下，学员发展了专业知识，并作为消化健康研究人员提供反馈，并整合了内部和外部顾问委员会的意见。对于那些将从高级学位中受益的人，TP通过莱尼研究生院/佐治亚州临床和转化科学联盟的临床研究硕士学位或转化研究证书计划的结构化学位课程。受训者受益于一个平衡的奖学金监督委员会，具有基本和翻译专业知识，负责任的研究（RCR）培训课程（RCR）培训课程以及由受训者驱动的个人发展计划（IDP）。通过TP的丰富计划，完成了个性化的TP（课程，指导研究经验，环境曝光，建议和专业发展），以实现教育和职业发展，为受训者的职业提供了丰富而持久的跳板。