P42ES027706 URI Sources, Transport, Exposure, and Effects of PFAS (STEEP) SRP

P42ES027706 PFAS (STEEP) SRP 的 URI 来源、传输、暴露和影响

• 批准号: 10399005
• 负责人: Rainer Lohmann
• 金额: $ 5万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-31 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10399005
• 关键词: Biological Monitoring; Biota; Chemicals; Ecosystem; Environment; Exposure to; Food; Food Chain; Food Webs; Fresh Water; Goals; Health; Hormonal; Human; Immune system; Insecta; Liver Failure; Maps; Organism; Pathway interactions; Phase; Phylogeny; Poison; Pollution; Public Health; Regulation; Research; Risk; Sampling; Signal Recognition Particle; Site; Source; System; Taxonomy; Trees; Water; base; bioaccumulation; feeding; novel; pollutant; reproductive success; uptake

Project Summary/Abstract This project will undertake the analysis of bioaccumulation of PFAS at the entry level for food-chain, focusing on freshwater insects. The project will explore the relationship between freshwater insects’ taxonomic groups and various PFAS compounds. The research focus will be placed on the following taxa: Ephemeroptera, Plecoptera, Trichoptera and Odonata. These insects encompass a variety of trophic functions, which reflect different exposure levels and uptake pathways of contaminants. These insects feeding types cover carnivores, omnivores, detritivores (fine detritivores, coarse detritivores) and periphytivores. These taxa are near the base of the trophic chain and constitute the gateway to chemical biomagnification throughout the food web. They are also of low mobility, which allows the characterization of sites relative to pollution load. Also, given these taxa are commonly used in biomonitoring, this study will evaluate their potential use as bioindicators for PFAS contamination. Specifically, this project will analyze how the concentration of PFAS varies within and among freshwater insects’ taxa and the relationship between aquatic insect taxonomic and trophic groups and concentration of PFAS. The relationship of freshwater insects’ diversity and PFAS compounds and concentration in water will also be examined. Additionally, the bioaccumulation factors (BAFs), the ratio of PFAS concentration in insects to that in water, will be calculated. The BAFs will be mapped on the insect phylogeny and trophic trees to understand better these relationships. Finally, this study will provide an understanding on whether novel PFAS that continue to be used and released into the environment are equally environmentally persistent and toxic as the phased-out compounds (PFOA, PFOS among others). This will pioneer and evoke further predictions on the effects of such emerging organic pollutants in freshwater ecosystems and potential public health threats. This project will further inform regulation on PFAS and conservation of freshwater ecosystems in the U.S. This project will leverage the passive samplers developed by URI-STEEP Project 4. It also aligns with the overall goals of STEEP Project 4, by investigating the presence of PFAS, and their bioaccumulation in biota. The project will critical to support the characterization of PFAS sources and determining human health risks in relation to contaminated waterways and bioaccumulation in aquatic biota, case of insects.

项目概要/摘要 本项目将对进口PFAS的生物累积性进行分析 食物链层面，重点关注淡水昆虫。该项目将探索 淡水昆虫分类群与各种PFAS之间的关系 化合物。研究重点将放在以下类群上：蜉蝣目， 鳞翅目、毛翅目和蜻蜓目。这些昆虫涵盖多种营养 函数，反映污染物的不同暴露水平和吸收途径。 这些昆虫的食性类型包括食肉动物、杂食动物、食碎屑动物（细食碎屑动物、 食粗碎屑动物）和食附生植物。这些类群靠近营养层的底部 链并构成整个食物网化学生物放大的门户。 它们的迁移率也较低，这使得可以表征相对于 污染负荷。此外，鉴于这些分类群常用于生物监测，本研究 将评估其作为 PFAS 污染生物指示剂的潜在用途。 具体来说，该项目将分析 PFAS 的浓度如何在 以及淡水昆虫类群与水生昆虫之间的关系 分类群和营养群以及 PFAS 浓度。的关系 淡水昆虫的多样性以及水中的 PFAS 化合物和浓度也将 被检查。此外，生物累积因子 (BAF)、PFAS 的比例 将计算昆虫中的浓度与水中的浓度。 BAF 将被映射到 昆虫系统发育和营养树，以更好地理解这些关系。最后， 这项研究将有助于了解新型 PFAS 是否会继续存在 使用和释放到环境中的物质具有同样的环境持久性和毒性 作为逐步淘汰的化合物（PFOA、PFOS 等）。这将开创并 引发对此类新兴有机污染物对环境影响的进一步预测 淡水生态系统和潜在的公共卫生威胁。该项目将进一步 为美国 PFAS 监管和淡水生态系统保护提供信息 该项目将利用 URI-STEEP 项目开发的被动采样器 4. 它还与 STEEP 项目 4 的总体目标保持一致，通过调查存在 PFAS 的含量及其在生物群中的生物累积性。该项目对于支持 PFAS 来源的表征并确定与之相关的人类健康风险 受污染的水道和水生生物群中的生物累积，昆虫的情况。