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Sources, Transport, Exposure & Effects of PFAS (STEEP) Center - RENEWAL

来源、运输、暴露

基本信息

批准号：
10866862
负责人：
Rainer Lohmann
金额：
$ 1.58万
依托单位：
UNIVERSITY OF RHODE ISLAND
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10866862
关键词：
Accounting Address Adverse effects Affect Air Area Atmosphere Awareness Biological Markers Breast Feeding Chemicals Child Cods Collaborations Communication Communication Tools Communities Complex Coronavirus Data Data Analyses Delaware Dependence Detection Development Diffuse Dust Education Endocrine Endocrine disruption Environmental Engineering technology Environmental Science Excretory function Exposure to FAIR principles Faeroe Islands Feedback Film Fishes Food Fostering Funding Goals Great Lakes Region Growth Health Human Human Milk Immunologic Markers Infant Intervention Joints Knowledge Laboratories Link Measurement Measures Mentors Mentorship Metabolic Metabolism Milk Modeling Molecular Outcome Paper Pathway interactions Policies Prevention strategy Privatization Process Public Health Research Research Project Grants Resources Rhode Island Risk Risk Assessment Rodent Safety Science Serum Shellfish Signal Recognition Particle Site Soil Source Superfund Time Tissues Toxicokinetics Training Translating Translational Research Tribes Uncertainty United States National Institutes of Health Universities Vaccination Vulnerable Populations Wampanoag Water Work absorption age related analytical tool aqueous base bioaccumulation cohesion cohort community engagement data management drinking water effectiveness evaluation environmental chemistry equity, diversity, and inclusion experience exposed human population exposure pathway ground water high school immunotoxicity improved indoor air innovation insight novel outreach oxidation pollutant predictive modeling prevent programs remediation response superfund site tool uptake

项目摘要

PROJECT SUMMARY/ABSTRACT – OVERALL PFAS have emerged as national priority pollutants, and more than 2000 sites contaminated by PFAS have been identified across the U.S., including 180 EPA-identified Superfund sites. Elevated human exposures to PFAS have been associated with adverse health outcomes, including metabolic disruption, immunotoxicity, and endocrine disruption, although exposure-dependence and individual vulnerability need to be better understood. STEEP II builds on the successful collaborative it established within the first STEEP SRP Center (STEEP I) to further advance the science, training, engagement and outreach in support of SRP mandates. STEEP II will continue to collaborate with the RI and MA state and federal agencies, and will expand its reach to work with DE, ME, NJ, and MI state agencies in support of their needs for knowledge on PFAS. The environmental engineering and chemistry projects will focus on the transport and transformation of PFAS precursors, as well as legacy, novel, and total PFAS. Novel detection tools will be developed and used to support remediation of PFAS- contaminated groundwater, the atmospheric transport and fate of PFAS, and to predict bioaccumulation of PFAS relative to modeling predictions. The Center will build on its leading research on the critical effects of PFAS in children, with a focus on immunotoxicity and metabolism. Given the public health importance of breastfeeding, STEEP II will focus on understanding cellular mechanisms that dictate PFAS uptake and elimination into milk and accumulation in the infant, thereby advancing understanding of toxicokinetic mechanisms and potentials for preventing PFAS from reaching human milk. STEEP II research projects, working with the Community Engagement Core (CEC) and the Data Management and Analysis Core (DMAC), will perform a thorough human exposure assessment for PFAS and risk assessment. STEEP trainees and mentors will remain key to the ongoing growth as a unified Center, via cross-cutting collaboration fostered by the Research Experience and Training Coordination Core (RETCC), and joint mentorship. STEEP II will include an additional focus on Diversity, Equity, and Inclusion (DEI) training for trainees and mentors alike. The STEEP II goals will address the following Specific Aims: Specific Aim 1: Assess the distribution, transformations, and bioaccumulation of PFAS Specific Aim 2: Investigate the processes affecting PFAS distribution and uptake and assess critical adverse effects in humans Specific Aim 3: Engage new and established stakeholders across multiple sites Specific Aim 4: Integrate STEEP internally and execute effective outreach and collaboration with stakeholders

项目摘要/摘要-总体

项目成果

期刊论文数量（88）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Human Health and Ocean Pollution.

DOI：
10.5334/aogh.2831
发表时间：
2020-12-03
期刊：
Annals of global health
影响因子：
2.9
作者：
Landrigan PJ;Stegeman JJ;Fleming LE;Allemand D;Anderson DM;Backer LC;Brucker-Davis F;Chevalier N;Corra L;Czerucka D;Bottein MD;Demeneix B;Depledge M;Deheyn DD;Dorman CJ;Fénichel P;Fisher S;Gaill F;Galgani F;Gaze WH;Giuliano L;Grandjean P;Hahn ME;Hamdoun A;Hess P;Judson B;Laborde A;McGlade J;Mu J;Mustapha A;Neira M;Noble RT;Pedrotti ML;Reddy C;Rocklöv J;Scharler UM;Shanmugam H;Taghian G;van de Water JAJM;Vezzulli L;Weihe P;Zeka A;Raps H;Rampal P
通讯作者：
Rampal P

Are Fluoropolymers Really of Low Concern for Human and Environmental Health and Separate from Other PFAS?

DOI：
10.1021/acs.est.0c03244
发表时间：
2020-10-20
期刊：
Environmental science & technology
影响因子：
11.4
作者：
Lohmann R;Cousins IT;DeWitt JC;Glüge J;Goldenman G;Herzke D;Lindstrom AB;Miller MF;Ng CA;Patton S;Scheringer M;Trier X;Wang Z
通讯作者：
Wang Z

Transport of Legacy Perfluoroalkyl Substances and the Replacement Compound HFPO-DA through the Atlantic Gateway to the Arctic Ocean-Is the Arctic a Sink or a Source?

DOI：
10.1021/acs.est.0c00228
发表时间：
2020-08-18
期刊：
Environmental science & technology
影响因子：
11.4
作者：
Joerss H;Xie Z;Wagner CC;von Appen WJ;Sunderland EM;Ebinghaus R
通讯作者：
Ebinghaus R

Birds of a Feather Eat Plastic Together: High Levels of Plastic Ingestion in Great Shearwater Adults and Juveniles Across Their Annual Migratory Cycle

物以类聚，鸟以食塑料：成年海鸥和幼海鸥在每年的迁徙周期中摄入大量塑料

DOI：
10.3389/fmars.2021.719721
发表时间：
2022
期刊：
Frontiers in Marine Science
影响因子：
3.7
作者：
Robuck, Anna R.;Hudak, Christine A.;Agvent, Lindsay;Emery, Gwenyth;Ryan, Peter G.;Perold, Vonica;Powers, Kevin D.;Pedersen, Johanna;Thompson, Michael A.;Suca, Justin J.
通讯作者：
Suca, Justin J.

Combining Social Science and Environmental Health Research for Community Engagement