Sources, Transport, Exposure and Effects of PFASs (STEEP)

项目摘要/摘要 由URI牵头的START(PFAS的来源、运输、暴露和影响)提议援助超级基金 解决多氟烷基和全氟烷基新出现和不断扩大的问题的研究方案 物质(全氟辛烷磺酸)污染。全氟辛烷磺酸是一种工业化合物，自 20世纪50年代，由于其独特的拒油和拒水性能，可用于各种产品。环境问题 全氟辛烷磺酸的传播和对人类健康的影响才刚刚开始显现。因此，美国环保局限制 关于全氟辛烷磺酸，自2009年首次公布以来，饮用水污染仍然是暂时性的。在 最近发布的2015年ToxProfile草案，ATSDR强调了不确定性，并无视最近关于 流行病学研究中的全氟辛烷磺酸暴露对人类健康的不利影响。因此，需要改进 确定风险特征是紧迫和及时的。 赛特的目标是更好地了解全氟辛烷磺酸进入环境的污染途径 通过地下水污染，通过食物网传播，并分发给脆弱的人类 在早期发育的人口中，部分通过母乳。具体地说，陡峭将成为 地下水原位测量结合地球化学模型评价全氟辛烷磺酸的来源 运输与命运(项目1)。生物医学研究将评估PFAS与免疫风险的关系 功能障碍和代谢异常，用于得出全氟辛烷磺酸的基准剂量水平，以改善 风险表征。由于早期开发过程中的过敏性，研究将集中在 宫内和出生后早期接触PFAS对器官功能障碍敏感指标的影响 平行的人类流行病学研究(项目2)和啮齿动物模型研究(项目3)。然后，环境问题 工程和化学研究将支持现场被动采样的开发和部署 水中全氟辛烷磺酸及其前体的技术(项目4)。因此，陡峭将解决在 通过结合有针对性的人体暴露评估和 确定现有全氟辛烷磺酸来源的化学计量学方法。 为了确保科学意识的遗产，传播广泛可获得的研究成果， 和受影响社区的实际应用，陡峭的岩芯将匹配强度和严格性 研究项目。陡峭的核心将用于a)准备下一代跨学科新兴 污染物研究人员(培训核心)，b)将陡峭项目产生的科学发现转化为 向各种内部和外部利益攸关方传播(研究翻译核心)，以及c)与CAPE接洽 受水膜污染的饮用水中PFASs暴露一线的鳕鱼群落 用于科德角联合基地的成型泡沫。行政核心，由主任领导，由内部领导 以及外部咨询委员会，将确保START项目和核心的整合。

PROJECT SUMMARY/ABSTRACT The URI-led STEEP (Sources, Transport, Exposure and Effects of PFASs) proposes to aid the Superfund Research Program in addressing the emerging and expanding problem of poly- and perfluorinated alkyl substances (PFASs) contamination. PFASs are industrial compounds that have been manufactured since the 1950s for use in a myriad of products due to their unique oil and water repellent properties. The environmental dissemination and the human health effects of PFASs are only beginning to emerge. Thus, the U.S. EPA limits for PFAS contamination of drinking water remain provisional since they were first published in 2009. In the recently released 2015 draft ToxProfile, ATSDR highlighted uncertainties and disregarded recent reports on adverse human health effects of PFAS exposures from epidemiological studies. Thus, the need for improved risk characterization is urgent and timely. STEEP aims to better understand the pathways of PFAS contamination from entry into the environment through groundwater contamination, dispersal through the food web, and distribution to vulnerable human populations during early development, in part through breast milk. Specifically, STEEP will characterize sources of PFAS through in situ groundwater measurements combined with geochemical modeling to assess transport and fate (Project 1). The biomedical studies will assess the relationship of PFAS to risk of immune dysfunction and metabolic abnormalities, to be used to derive benchmark doses levels for PFASs for improved risk characterization. Due to the hypersusceptibility during early development, the research will focus on the impact of in utero and early postnatal PFAS exposures on sensitive indicators of organ dysfunctions through parallel human epidemiologic studies (Project 2) and rodent model studies (Project 3). Then, environmental engineering and chemistry research will support the development and deployment of in situ passive sampling techniques for PFAS and their precursors in water (Project 4). STEEP will thereby address limitations in the current understanding of human exposure to PFAS by combining targeted human exposure assessment with chemometric approaches to characterize existing PFAS sources. To ensure a legacy of scientific awareness, the dissemination of broadly accessible research findings, and practical application by affected communities, STEEP Cores will match the intensity and rigor of the research projects. STEEP Cores will serve to a) prepare the next generation of interdisciplinary emerging contaminant researchers (Training Core), b) translate scientific findings generated by STEEP projects for dissemination to various internal and external stakeholders (Research Translation Core), and c) engage Cape Cod communities on the front lines of PFASs exposure through drinking water contaminated by Aqueous film forming foam use at Joint Base Cape Cod. The Administrative Core, led by its directors, and guided by Internal and External Advisory Committees, will ensure the integration of STEEP’s projects and cores.