Passive samplers in support of Remediation, Detection and Bioaccumulation of PFAS

支持 PFAS 修复、检测和生物累积的被动采样器

• 批准号: 10704017
• 负责人: Rainer Lohmann
• 金额: $ 29.38万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704017
• 关键词: Address; Air; American; Arctic Regions; Atmosphere; Binding; Biological Availability; Biota; Cellular Assay; Chemicals; Chemistry; Child; Cods; Collaborations; Consumption; Data; Delaware; Detection; Development; Dust; Effectiveness; Embryo; Environment; Environmental Exposure; Excision; Exposure to; FAIR principles; Faeroe Islands; Fellowship; Fiber; Film; Fishes; Food Analysis; Gases; Goals; Hazardous Substances; Health; Household; Human; In Situ; Inhalation; Joints; Knowledge; Laboratories; Laboratory Study; Link; Malignant Neoplasms; Measures; Medial; Metabolic; Metabolic Biotransformation; Methods; Monitor; Nature; Participant; Performance; Periodicity; Phase; Policies; Poly-fluoroalkyl substances; Polyethylenes; Polymers; Production; Proxy; Research; Research Project Grants; Resistance; Rodent Model; Sampling; Screening procedure; Seafood; Serum; Shellfish; Signal Recognition Particle; Site; Source; Statistical Data Interpretation; Technology; Time; Tissues; Toxic effect; Translational Research; US State; Validation; Water; Water Supply; Work; air sampler; air sampling; aqueous; bioaccumulation; cost effective; design; drinking water; environmental transport; exposed human population; exposure pathway; field study; food chain contamination; ground water; indoor air; indoor dust; innovation; novel; particle; pollutant; polyacrylate; remediation; screening; success; tool; uptake

PROJECT SUMMARY/ABSTRACT – PROJECT 4 DETECTION STEEP II Project 4–Detection and Remediation (P4-Detection), will further develop, validate, field-test and deploy passive sampling tools for per- and polyfluorinated alkyl substances (PFAS) in water, biota, air and dust. The field-validation and applications of passive samplers offer several key advances for the detection of PFAS including (i) assessment of relevant human exposure via time-weighted average concentrations, (ii) aiding in identifying the extent of site contamination, and (iii) remediation via simple adsorbents and reliable monitoring tools that can be deployed before, during, and following remediation to verify success. P4–Detection offers several innovative research components to address knowledge gaps surrounding environmental exposure to legacy and novel PFAS, and to provide novel tools to stakeholders. For example, P4–Detection will develop a simple, but effective filter for PFAS in groundwater, and use its passive samplers to monitor a field-based ex situ remediation trial for PFAS in groundwater on Cape Cod (Aim 1). P4–Detection will simultaneously characterize PFAS bioaccumulation in wildlife and field-test passive samplers in the Delaware River (Aim 2), while using passive samplers to measure the biotransformation and bioaccumulation of PFAS in controlled laboratory exposures. P4–Detection will also contribute unique tools and data on PFAS in outdoor and indoor air, and dust to inform STEEP II’s PFAS exposure assessment (Aim 3). P4–Detection will collaborate with P1–Exposure to assess the importance of atmospheric transport of PFAS, another research gap and significant need for STEEP’s stakeholders (Aim 3). P4–Detection will thereby address the SRP mandates of developing “methods to reduce the amount and toxicity of hazardous substances” and “methods and technologies to detect hazardous substances in the environment.” The work of P4–Detection is well-integrated with the other STEEP II research projects and cores: it will maintain strong links with P1–Exposure, with a joint focus on bioaccumulation, and the use of passive samplers for indoor and outdoor air sampling of PFAS; continue work with P3–Mechanisms on chemical analysis of PFAS and share mixture profiles of PFAS in cell assays and rodent models; work with P2–Critical Effects to assess the contribution of indoor air and dust to PFAS exposure in the Faroe Islands relative to seafood consumption as part of PI Lohmann’s Fulbright Arctic Initiative fellowship; and exchange samples with P1–Exposure to compare the results of extractable organofluorine (EOF) analysis and perform non-target analysis for the other projects. Lastly, P4–Detection will work with STEEP II’s research translation team, states, and U.S. EPA to disseminate results and applications of passive samplers for PFASs to state and federal agencies; with the DMAC on adhering to FAIR data principles and statistical analysis of the results; with the CEC on indoor air, dust, fish/shellfish and local grown food analysis on Cape Cod; and with the RETCC and the trainee action teams on joint research exchanges, activities, and policy initiatives.

项目摘要/摘要--项目4检测 陡峭二项目4--检测和补救(P4--检测)，将进一步开发、验证、实地测试和 部署水、生物群、空气和灰尘中全氟和多氟烷基物质(PFAS)的被动采样工具。 被动采样器的现场验证和应用为全氟辛烷磺酸的检测提供了几个关键的进展 包括：(1)通过时间加权平均浓度评估相关的人体接触情况；(2)协助 确定场地污染的程度，以及(3)通过简单的吸附剂和可靠的监测进行补救 可在补救之前、期间和之后部署以验证成功的工具。 P4-Detect提供了几个创新的研究组件来解决周围的知识差距 在环境中暴露于遗留和新型全氟辛烷磺酸，并向利益攸关方提供新工具。例如, P4-Detect将开发一种简单但有效的过滤器，用于地下水中的PFAS，并使用其被动采样器 监测科德角地下水中全氟辛烷磺酸的实地异地修复试验(目标1)。P4-检测 将同时表征全氟辛烷磺酸在野生动物中的生物积累和特拉华州现场测试的被动采样器 河流(目标2)，同时使用被动采样器测量全氟辛烷磺酸的生物转化和生物积累 受控的实验室暴露。P4-Detect还将在户外提供关于PFAS的独特工具和数据 以及室内空气和粉尘，以便为第二阶段的全氟辛烷磺酸暴露评估提供信息(目标3)。P4-检测将进行协作 通过接触P1来评估全氟辛烷磺酸大气传输的重要性，另一项研究差距和 对赛特的利益相关者的重大需求(目标3)。P4--检测将因此解决以下SRP任务 制定“减少危险物质的数量和毒性的方法”和“减少危险物质的数量和毒性的方法和 检测环境中有害物质的技术。 P4-探测的工作与其他START II研究项目和核心很好地结合在一起：它将 保持与P1接触的密切联系，共同关注生物积累，并使用被动采样器 用于室内和室外空气采样；继续与P3合作--全氟辛烷磺酸的化学分析机制 并在细胞分析和啮齿动物模型中共享全氟辛烷磺酸的混合物配置文件；使用P2关键效应来评估 与海鲜消费相比，室内空气和粉尘对法罗群岛全氟辛烷磺酸暴露的贡献 作为PI Lohmann富布赖特北极倡议奖学金的一部分；并与P1交换样本-暴露于 比较可提取有机氟(EOF)分析的结果，并对另一种进行非靶标分析 项目。最后，P4-Detect将与Stop II的研究翻译团队、各州和美国环保局合作，以 向州和联邦机构传播全氟辛烷磺酸被动采样器的结果和应用；与 DMAC坚持公平数据原则，对结果进行统计分析；CEC关于室内空气， 对科德角的灰尘、鱼类/贝类和当地种植的食物进行分析；与RETCC和受训人员行动小组合作 关于联合研究交流、活动和政策倡议。