Sources, Transport, Exposure & Effects of PFAS (STEEP) Center - RENEWAL

项目摘要/摘要--总体 全氟辛烷磺酸已成为国家优先污染物，已有2000多个地点受到全氟辛烷磺酸的污染。 在全美范围内确定，包括180个EPA确定的超级基金地点。人类暴露于全氟辛烷磺酸的增加 与不良健康后果有关，包括代谢紊乱、免疫毒性和 内分泌紊乱，尽管暴露依赖和个体脆弱性需要更好地理解。 STARET II建立在首个START SRP中心(START I)内建立的成功协作基础上，以 进一步推进科学、培训、参与和外联，以支持可持续发展方案的任务。陡峭的II将 继续与国际扶轮和马萨诸塞州和联邦机构合作，并将扩大其与DE的合作范围， 我、新泽西州和密歇根州的州政府机构，以支持他们对全氟辛烷磺酸知识的需求。环境工程学 化学项目将侧重于全氟辛烷磺酸前体的运输和转化，以及遗留问题， 新颖、全面的全氟辛烷磺酸。将开发和使用新的检测工具来支持对全氟辛烷磺酸的补救- 受污染的地下水、全氟辛烷磺酸的大气迁移和去向以及预测全氟辛烷磺酸的生物积累 相对于建模预测。该中心将在#年对全氟辛烷磺酸关键影响的领先研究基础上再接再厉。 儿童，重点是免疫毒性和新陈代谢。鉴于母乳喂养对公众健康的重要性， START II将侧重于了解决定牛奶中全氟辛烷磺酸摄取和消除的细胞机制 和在婴儿体内的蓄积，从而促进了对毒物动力学机制和潜在的 防止全氟辛烷磺酸接触到母乳。陡峭II研究项目，与社区合作 客户关系核心(CEC)和数据管理和分析核心(DMAC)将执行全面的人力 全氟辛烷磺酸的暴露评估和风险评估。尖锐的实习生和导师仍将是 作为统一中心持续增长，通过研究经验和 培训协调核心(RETCC)和联合指导。陡峭II将包括对多样性的额外关注， 为学员和导师提供公平、包容(Dei)培训。陡峭的II目标将解决以下问题 具体目标： 具体目标1：评估全氟辛烷磺酸的分布、转化和生物积累 具体目标2：调查影响全氟辛烷磺酸分配和吸收的过程，并评估关键 对人类的不良影响 具体目标3：在多个站点吸引新的和已建立的利益相关者 具体目标4：在内部整合SHART，并开展有效的外联和协作 利益相关者

PROJECT SUMMARY/ABSTRACT – OVERALL PFAS have emerged as national priority pollutants, and more than 2000 sites contaminated by PFAS have been identified across the U.S., including 180 EPA-identified Superfund sites. Elevated human exposures to PFAS have been associated with adverse health outcomes, including metabolic disruption, immunotoxicity, and endocrine disruption, although exposure-dependence and individual vulnerability need to be better understood. STEEP II builds on the successful collaborative it established within the first STEEP SRP Center (STEEP I) to further advance the science, training, engagement and outreach in support of SRP mandates. STEEP II will continue to collaborate with the RI and MA state and federal agencies, and will expand its reach to work with DE, ME, NJ, and MI state agencies in support of their needs for knowledge on PFAS. The environmental engineering and chemistry projects will focus on the transport and transformation of PFAS precursors, as well as legacy, novel, and total PFAS. Novel detection tools will be developed and used to support remediation of PFAS- contaminated groundwater, the atmospheric transport and fate of PFAS, and to predict bioaccumulation of PFAS relative to modeling predictions. The Center will build on its leading research on the critical effects of PFAS in children, with a focus on immunotoxicity and metabolism. Given the public health importance of breastfeeding, STEEP II will focus on understanding cellular mechanisms that dictate PFAS uptake and elimination into milk and accumulation in the infant, thereby advancing understanding of toxicokinetic mechanisms and potentials for preventing PFAS from reaching human milk. STEEP II research projects, working with the Community Engagement Core (CEC) and the Data Management and Analysis Core (DMAC), will perform a thorough human exposure assessment for PFAS and risk assessment. STEEP trainees and mentors will remain key to the ongoing growth as a unified Center, via cross-cutting collaboration fostered by the Research Experience and Training Coordination Core (RETCC), and joint mentorship. STEEP II will include an additional focus on Diversity, Equity, and Inclusion (DEI) training for trainees and mentors alike. The STEEP II goals will address the following Specific Aims: Specific Aim 1: Assess the distribution, transformations, and bioaccumulation of PFAS Specific Aim 2: Investigate the processes affecting PFAS distribution and uptake and assess critical adverse effects in humans Specific Aim 3: Engage new and established stakeholders across multiple sites Specific Aim 4: Integrate STEEP internally and execute effective outreach and collaboration with stakeholders