Sources, Transport, Exposure & Effects of PFAS (STEEP) Center - RENEWAL

项目总结/摘要-总体 PFAS已成为国家优先污染物，2000多个受PFAS污染的场地已被 在美国各地都有发现，包括180个环保署认定的超级基金地点。人类暴露于PFAS的水平升高 与不良健康结果有关，包括代谢紊乱、免疫毒性和 内分泌干扰，但需要更好地了解依赖性和个人的脆弱性。 STEEP II建立在它在第一个STEEP SRP中心（STEEP I）内建立的成功合作的基础上， 进一步推进科学、培训、参与和外联，以支持简化报告程序的任务。STEEP II将 继续与国际扶轮和马州及联邦机构合作，并将扩大其与教育部合作的范围， ME，NJ和MI州机构，以支持他们对PFAS知识的需求。环境工程 和化学项目将侧重于PFAS前体的运输和转化，以及遗留问题， 新的，完全的PFAS。将开发新的检测工具，用于支持PFAS的补救- PFAS污染地下水、大气迁移和归宿，并预测PFAS的生物累积 相对于模型预测。该中心将建立在其领先的研究PFAS的关键影响， 儿童，重点是免疫毒性和代谢。鉴于母乳喂养对公共健康的重要性， STEEP II将专注于了解决定PFAS吸收和消除到牛奶中的细胞机制 并在婴儿体内积累，从而促进对毒代动力学机制和 防止PFAS进入母乳。STEEP II研究项目，与社区合作 参与核心（CEC）和数据管理和分析核心（DMAC），将执行一个彻底的人类 PFAS的暴露评估和风险评估。STEEP学员和导师将继续成为 作为一个统一的中心，通过研究经验促进的跨领域合作， 培训协调核心（RETCC）和联合辅导。STEEP II将包括对多样性的额外关注， 为学员和导师提供平等和包容培训。STEEP II目标将解决以下问题 具体目标： 具体目标1：评估PFAS的分布、转化和生物累积性 具体目标2：调查影响PFAS分布和吸收的过程， 对人体的不良影响 具体目标3：吸引多个地点的新老利益相关者 具体目标4：在内部整合STEEP，并与 利益方

PROJECT SUMMARY/ABSTRACT – OVERALL PFAS have emerged as national priority pollutants, and more than 2000 sites contaminated by PFAS have been identified across the U.S., including 180 EPA-identified Superfund sites. Elevated human exposures to PFAS have been associated with adverse health outcomes, including metabolic disruption, immunotoxicity, and endocrine disruption, although exposure-dependence and individual vulnerability need to be better understood. STEEP II builds on the successful collaborative it established within the first STEEP SRP Center (STEEP I) to further advance the science, training, engagement and outreach in support of SRP mandates. STEEP II will continue to collaborate with the RI and MA state and federal agencies, and will expand its reach to work with DE, ME, NJ, and MI state agencies in support of their needs for knowledge on PFAS. The environmental engineering and chemistry projects will focus on the transport and transformation of PFAS precursors, as well as legacy, novel, and total PFAS. Novel detection tools will be developed and used to support remediation of PFAS- contaminated groundwater, the atmospheric transport and fate of PFAS, and to predict bioaccumulation of PFAS relative to modeling predictions. The Center will build on its leading research on the critical effects of PFAS in children, with a focus on immunotoxicity and metabolism. Given the public health importance of breastfeeding, STEEP II will focus on understanding cellular mechanisms that dictate PFAS uptake and elimination into milk and accumulation in the infant, thereby advancing understanding of toxicokinetic mechanisms and potentials for preventing PFAS from reaching human milk. STEEP II research projects, working with the Community Engagement Core (CEC) and the Data Management and Analysis Core (DMAC), will perform a thorough human exposure assessment for PFAS and risk assessment. STEEP trainees and mentors will remain key to the ongoing growth as a unified Center, via cross-cutting collaboration fostered by the Research Experience and Training Coordination Core (RETCC), and joint mentorship. STEEP II will include an additional focus on Diversity, Equity, and Inclusion (DEI) training for trainees and mentors alike. The STEEP II goals will address the following Specific Aims: Specific Aim 1: Assess the distribution, transformations, and bioaccumulation of PFAS Specific Aim 2: Investigate the processes affecting PFAS distribution and uptake and assess critical adverse effects in humans Specific Aim 3: Engage new and established stakeholders across multiple sites Specific Aim 4: Integrate STEEP internally and execute effective outreach and collaboration with stakeholders