Sources, Transport, Exposure & Effects of PFAS (STEEP) Center - RENEWAL

来源、运输、暴露

• 批准号: 10704006
• 负责人: Rainer Lohmann
• 金额: $ 153.43万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704006
• 关键词: Accounting; Address; Adverse effects; Affect; Air; Area; Atmosphere; Awareness; Biological Markers; Breast Feeding; Chemicals; Child; Cods; Collaborations; Communication; Communication Tools; Communities; Complex; Coronavirus; Data; Data Analyses; Delaware; Dependence; Detection; Development; Diffuse; Dust; Education; Endocrine; Endocrine disruption; Environmental Engineering technology; Environmental Science; Excretory function; Exposure to; FAIR principles; Faeroe Islands; Feedback; Film; Fishes; Food; Fostering; Funding; Goals; Great Lakes Region; Growth; Health; Human; Human Milk; Immunologic Markers; Infant; Intervention; Joints; Knowledge; Laboratories; Link; Measurement; Measures; Mentors; Mentorship; Metabolic; Metabolism; Milk; Modeling; Molecular; Outcome; Paper; Pathway interactions; Policies; Prevention strategy; Privatization; Process; Public Health; Research; Research Project Grants; Resources; Rhode Island; Risk; Risk Assessment; Rodent; Safety; Science; Serum; Shellfish; Signal Recognition Particle; Site; Soil; Source; Superfund; Time; Tissues; Toxicokinetics; Training; Translating; Translational Research; Tribes; Uncertainty; United States National Institutes of Health; Universities; Vaccination; Vulnerable Populations; Wampanoag; Water; Work; absorption; age related; analytical tool; aqueous; base; bioaccumulation; cohesion; cohort; community engagement; data management; drinking water; effectiveness evaluation; environmental chemistry; equity, diversity, and inclusion; experience; exposed human population; exposure pathway; ground water; high school; immunotoxicity; improved; indoor air; innovation; insight; novel; outreach; oxidation; pollutant; predictive modeling; prevent; programs; remediation; response; superfund site; tool; uptake

PROJECT SUMMARY/ABSTRACT – OVERALL PFAS have emerged as national priority pollutants, and more than 2000 sites contaminated by PFAS have been identified across the U.S., including 180 EPA-identified Superfund sites. Elevated human exposures to PFAS have been associated with adverse health outcomes, including metabolic disruption, immunotoxicity, and endocrine disruption, although exposure-dependence and individual vulnerability need to be better understood. STEEP II builds on the successful collaborative it established within the first STEEP SRP Center (STEEP I) to further advance the science, training, engagement and outreach in support of SRP mandates. STEEP II will continue to collaborate with the RI and MA state and federal agencies, and will expand its reach to work with DE, ME, NJ, and MI state agencies in support of their needs for knowledge on PFAS. The environmental engineering and chemistry projects will focus on the transport and transformation of PFAS precursors, as well as legacy, novel, and total PFAS. Novel detection tools will be developed and used to support remediation of PFAS- contaminated groundwater, the atmospheric transport and fate of PFAS, and to predict bioaccumulation of PFAS relative to modeling predictions. The Center will build on its leading research on the critical effects of PFAS in children, with a focus on immunotoxicity and metabolism. Given the public health importance of breastfeeding, STEEP II will focus on understanding cellular mechanisms that dictate PFAS uptake and elimination into milk and accumulation in the infant, thereby advancing understanding of toxicokinetic mechanisms and potentials for preventing PFAS from reaching human milk. STEEP II research projects, working with the Community Engagement Core (CEC) and the Data Management and Analysis Core (DMAC), will perform a thorough human exposure assessment for PFAS and risk assessment. STEEP trainees and mentors will remain key to the ongoing growth as a unified Center, via cross-cutting collaboration fostered by the Research Experience and Training Coordination Core (RETCC), and joint mentorship. STEEP II will include an additional focus on Diversity, Equity, and Inclusion (DEI) training for trainees and mentors alike. The STEEP II goals will address the following Specific Aims: Specific Aim 1: Assess the distribution, transformations, and bioaccumulation of PFAS Specific Aim 2: Investigate the processes affecting PFAS distribution and uptake and assess critical adverse effects in humans Specific Aim 3: Engage new and established stakeholders across multiple sites Specific Aim 4: Integrate STEEP internally and execute effective outreach and collaboration with stakeholders

项目概要/摘要——总体 PFAS已成为国家重点污染物，2000多个受PFAS污染的场所已得到治理 美国各地已确定，其中包括 EPA 确定的 180 个超级基金站点。人类对 PFAS 的暴露量增加 与不良健康结果有关，包括代谢紊乱、免疫毒性和 内分泌干​​扰，尽管需要更好地了解暴露依赖性和个人脆弱性。 STEEP II 建立在第一个 STEEP SRP 中心 (STEEP I) 内建立的成功协作基础上 进一步推进科学、培训、参与和推广，以支持 SRP 的任务。 《极限巅峰2》将 继续与 RI 和 MA 州及联邦机构合作，并将扩大与 DE 的合作范围， 缅因州、新泽西州和密歇根州机构支持他们对 PFAS 知识的需求。环境工程 和化学项目将重点关注 PFAS 前体以及遗留物的运输和转化， 新颖的、总的 PFAS。将开发并使用新型检测工具来支持 PFAS 的修复 污染地下水、PFAS 的大气迁移和归宿，并预测 PFAS 的生物累积 相对于建模预测。该中心将以其关于 PFAS 对健康的关键影响的领先研究为基础 儿童，重点关注免疫毒性和代谢。鉴于母乳喂养对公共卫生的重要性， STEEP II 将重点了解决定牛奶中 PFAS 吸收和消除的细胞机制 和在婴儿体内的积累，从而增进对毒代动力学机制和潜力的理解 防止 PFAS 进入母乳。 STEEP II 研究项目，与社区合作 参与核心（CEC）和数据管理和分析核心（DMAC）将执行彻底的人力 PFAS 暴露评估和风险评估。 STEEP 学员和导师仍将是 STEEP 的关键 通过研究经验和促进的跨领域合作，作为一个统一的中心不断发展 培训协调核心 (RETCC) 和联合指导。 STEEP II 将额外关注多样性， 为学员和导师提供公平和包容 (DEI) 培训。 STEEP II 目标将解决以下问题 具体目标： 具体目标 1：评估 PFAS 的分布、转化和生物累积性 具体目标 2：调查影响 PFAS 分布和吸收的过程并评估关键 对人类的不良影响 具体目标 3：跨多个地点吸引新老利益相关者 具体目标 4：在内部整合 STEEP 并与 利益相关者