5P42ES027706 Sources, Transport, Exposure, and Effects of PFASs (STEEP) SRP

5P42ES027706 PFAS (STEEP) SRP 的来源、传输、暴露和影响

• 批准号: 10380984
• 负责人: Rainer Lohmann
• 金额: $ 1.5万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-20 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10380984
• 关键词: Career Choice; Collaborations; Communities; Cyclodextrins; Dangerousness; Data Analyses; Detection; Environment; Exposure to; Funding; Grant; Label; Laboratories; Learning; Liquid substance; Mass Spectrum Analysis; Measurement; Measures; Mentorship; Methods; Monitor; Outcome; Phase; Polyethylenes; Private Sector; Privatization; Process; Research; Rhode Island; Sampling; Signal Recognition Particle; Source; Superfund; Surface; Temperature; Testing; Time; Travel; Tube; Universities; Water; Work; cost; design; drinking; experience; externship; follow-up; ground water; improved; instrument; interest; meetings; novel; operation; programs; remediation; skills; tool; uptake

With worldwide concern growing over the emerging persistent contaminates known as Per- and poly-fluorinated alkyl substances (PFAS) there is a distinct need for affordable and reliable detection tools. As part of my ongoing research as a trainee of the STEEP Superfund Center, I am in the process of validating a novel tube passive sampler that will be used to measure PFAS contamination in surface and ground waters. Current work has focused on validating the uptake of PFAS across environmental conditions like flow, water temperature, and presence of biofouling using a microporous polyethylene tube filled with a commercially available sorbent used as the receiving phase for PFAS. While the current sorbent is commonly used for PFAS extraction, a novel cyclodextrin sorbent designed for PFAS remediation, could boast higher sorption for a wider range of PFAS, thus improving uptake of PFAS within the walls of this tube passive sampler. To test this, I propose travelling to the private company that produces this cyclodextrin sorbent, Cyclopure Inc. in Skokie IL, to validate a method for extraction of both native and mass labeled surrogate compounds from my passive samplers, loaded with their sorbent. Cyclopure Inc. is a working under an SRP-funded grant (R43ES029401), and their novel sorbent called DEXSORB+, was created for remediation of PFAS while being re-useable. This novel sorbent is also more affordable than the currently used sorbent, costing about 20 times less per 50 grams of sorbent. In addition to validating an extraction method for a wider range of PFAS standards than available in my current laboratory at the University of Rhode Island, I will gain direct mentorship while analyzing my own samples on Cyclopure’s Liquid Chromatograph/Mass Spectrometry instrument. With limited access to this instrument at my university, I will have valuable time to learn operation, troubleshooting, and data analysis under the guidance of Matt Notter and Frank Cassou of Cyclopure Inc. Through this experience, I will get the unique opportunity to learn about the skills that interests private sector companies before graduating from my doctoral program. Follow up collaborations using passive samplers with state and federal agencies will give me broad exposure to many career paths that I will consider as I finish my studies. The expected outcome of this externship will be an improved design for a passive sampler for PFAS in surface and ground waters that will be affordable, reusable, and reliable for all stakeholders. These results will be shared at the SRP annual meeting following the completion of the externship, which will allow for a wide variety of stakeholders to be introduced to this potential tool for PFAS measurements.

随着全球对新出现的持久性污染物的关注日益增加， 和多氟烷基物质（PFAS），有一个负担得起的和可靠的明显需求， 检测工具。作为STEEP超级基金中心的实习生，我正在进行研究， 我正在验证一种新的管式被动采样器，它将用于测量PFAS 地表水和地下沃茨的污染。目前的工作重点是验证 PFAS在不同环境条件下的吸收，如流量、水温和 使用填充有市售吸附剂的微孔聚乙烯管的生物污垢 用作PFAS的接收相。虽然目前的吸附剂通常用于PFAS 萃取，一种新的环糊精吸附剂设计的PFAS修复，可以拥有更高的 吸附范围更广的PFAS，从而改善该管壁内PFAS的吸收 被动采样器为了验证这一点，我建议前往生产这种产品的私人公司， 环糊精吸附剂，Cyclopure Inc.在Skokie IL，为了验证提取 天然和质量标记的替代化合物，从我的被动采样器，加载他们的 吸附剂Cyclopure Inc.是在SRP资助的赠款（R43 ES 029401）下工作，他们的小说 被称为DEXSORB+的吸附剂被创建用于PFAS的修复，同时可重复使用。这 新型吸附剂也比目前使用的吸附剂更便宜，成本约为20倍 每50克吸附剂更少。除了验证更广泛的提取方法外， PFAS标准比我目前在罗得岛大学的实验室，我会 在Cyclopure液体上分析我自己的样品时获得直接指导 色谱/质谱仪。在我的实验室里， 大学期间，我将有宝贵的时间学习操作、故障排除和数据分析， 在Cyclopure公司的Matt Notter和Frank Cassou的指导下，通过这次经历，我将 获得独特的机会，了解私营部门公司感兴趣的技能 在我博士毕业之前使用被动采样器跟踪协作 与州和联邦机构的合作将使我广泛接触到许多职业道路， 在我完成学业的时候。这次实习的预期结果将是一个改进的 设计一种可负担得起的用于地表水和地下沃茨中PFAS的被动采样器， 可重复使用，对所有利益相关者来说都是可靠的。这些结果将在SRP年度会议上分享。 会议结束后，校外，这将允许各种各样的 向利益相关者介绍这一潜在的PFAS测量工具。