Bioengineering Center of Regeneration and Formation of Tissues (SC BioCRAFT)

COBRE 第三阶段应用旨在维持前十年建立的研究基础设施 NIGMS 资金。我们的 COBRE“南卡罗来纳州再生和形成生物工程中心 Tissues” has become a nationally recognized, collaborative center with unique strengths in bioengineering approaches to regenerative medicine.三个基本主题定义了该中心的研究： 进展 biomaterial design and application; in situ tissue repair with targeted therapies; and applying the principles of 正常发育生物学到再生医学或基于干细胞的组织工程。 SC生物工艺 实现这三个转化目标的成就包括招聘 10 名新教师、提供指导 培训 23 名 COBRE 目标教员，并开发两个研究核心设施。程序化 成果包括 26 项独立的 NIH 研究奖、62 项来自其他机构的研究奖 faculty, and >550 peer reviewed publications.南卡罗来纳州经济卓越中心：SmartState 与伙伴关系授予再生医学和先进组织生物制造领域的三名特聘教授 与克莱姆森大学和南卡罗来纳大学合作。 SC BioCRAFT 参与成功更新了 全州范围内的 INBRE 奖，重点关注生物工程/再生医学。 对于此 P30 申请，计划在未来五年内过渡到独立于 NIH/NIGMS 支持 是增强和升级我们的核心技术，提高其竞争力，吸引更多的使用 (and cost recovery), and to promote new research collaborations with our Center that can lead to submission of 竞争性研究应用并扩大我们在全州范围内的影响力，特别是其他 IDeA 中心。一个七 步骤，五年战略计划，包括实施费用结构、试点项目/优惠券计划、外展 建议开展活动和计划开发以维持 SC BioCRAFT/COBRE 中心及其 科学核心（生物材料工程和测试以及转化研究成像）。成立 克莱姆森 SC BioCRAFT COBRE 主任将领导行政核心，并由两名 来自南卡罗来纳医科大学的杰出科学家亲自指导 COBRE。 这三位领导人将共同充当该中心的主要运营部门。 An External Advisory Committee will provide ongoing assessment and evaluation of the Center's progress. Institutional commitments from the 研究副总裁约 200 万美元，将帮助确保计划性增长发展和长期 term sustainability of the Center.

This COBRE Phase III application is aimed at sustaining the research infrastructure built during the first ten years of NIGMS funding. Our COBRE “South Carolina Bioengineering Center for Regeneration and Formation of Tissues” has become a nationally recognized, collaborative center with unique strengths in bioengineering approaches to regenerative medicine. Three underlying themes define the Center's research: advance biomaterial design and application; in situ tissue repair with targeted therapies; and applying the principles of normal developmental biology to regenerative medicine or stem cell based tissue engineering. SC BioCRAFT accomplishments towards these three translational goals include the recruitment of 10 new faculty, mentoring and training of 23 COBRE target faculty, and the development of two research core facilities. Programmatic outcomes include 26 independent NIH research awards, 62 research awards from other agencies to target faculty, and >550 peer reviewed publications. South Carolina Centers of Economic Excellence: SmartState awarded three endowed chairs in Regenerative Medicine and Advanced Tissue Biofabrication in partnerships with Clemson and the University of South Carolina. SC BioCRAFT participated in the successful renewal of a statewide INBRE award with a focus on bioengineering/regenerative medicine. For this P30 application, the plan transitioning to independence of NIH/NIGMS support during the next five years is to enhance and upgrade our core technologies, to increase their competitiveness, to attract greater usage (and cost recovery), and to promote new research collaborations with our Center that can lead to submission of competitive research applications and broaden our statewide outreach, especially to other IDeA centers. A seven step, five-year strategic plan including implementing fee structures, pilot projects/voucher program, outreach activities and programmatic development is proposed to sustain the SC BioCRAFT/COBRE center and its scientific cores (Biomaterials Engineering and Testing and Translational Research Imaging). The founding director of Clemson's SC BioCRAFT COBRE will lead the Administrative Core and will be assisted by two outstanding scientists from Medical University of South Carolina who have themselves directed COBREs. Together, these three leaders will act as the main operational arm of the Center. An External Advisory Committee will provide ongoing assessment and evaluation of the Center's progress. Institutional commitments from the Vice President for Research, ~2 million dollars, will help ensure programmatic growth development and long- term sustainability of the Center.