Bioengineering Center of Regeneration and Formation of Tissues (SC BioCRAFT)

COBRE第三阶段应用旨在维持前十年建立的研究基础设施 NIGMS的资金。我们的COBRE "南卡罗来纳州生物工程中心的再生和形成 组织"已成为一个全国公认的，在生物工程方面具有独特优势的合作中心 再生医学的方法三个基本主题定义了该中心的研究： 生物材料设计和应用;原位组织修复与靶向治疗;并应用的原则， 正常发育生物学到再生医学或基于干细胞的组织工程。SC BioCRAFT 实现这三个转化目标的成就包括招聘10名新教师，指导 培训23名COBRE目标教员，并开发两个研究核心设施。纲领性 结果包括26个独立的NIH研究奖，62个来自其他机构的研究奖， 教师，和> 550同行评审的出版物。南卡罗来纳州经济卓越中心：SmartState 授予再生医学和先进组织生物制品的三个捐赠椅子的合作伙伴关系 与克莱姆森和南卡罗来纳州大学合作。SC BioCRAFT参与了一个成功的更新， 全州范围内的INBRE奖，重点是生物工程/再生医学。 对于此P30应用程序，计划在未来五年内过渡到NIH/NIGMS支持的独立性 是加强和提升我们的核心技术，提高它们的竞争力，吸引更多的使用， (and成本回收），并促进与我们中心的新的研究合作，可以导致提交 竞争力的研究应用，并扩大我们的全州范围，特别是其他IDEA中心。一个七 步骤、五年战略计划，包括实施收费结构、试点项目/代金券方案、推广 提出了一些活动和项目发展的建议，以维持SC BioCRAFT/COBRE中心及其 科学核心（生物材料工程和测试以及转化研究成像）。成立 克莱姆森的SC生物工艺COBRE主任将领导行政核心，并由两名 来自南卡罗来纳州医科大学的杰出科学家，他们亲自指导了COBREs。 这三位领导人将共同担任该中心的主要业务部门。外部咨询委员会 将对中心的进展情况进行持续的评估和评价。联合国的机构承诺 研究副总裁，约200万美元，将有助于确保方案的发展和长期的增长， 中心的可持续性。

This COBRE Phase III application is aimed at sustaining the research infrastructure built during the first ten years of NIGMS funding. Our COBRE “South Carolina Bioengineering Center for Regeneration and Formation of Tissues” has become a nationally recognized, collaborative center with unique strengths in bioengineering approaches to regenerative medicine. Three underlying themes define the Center's research: advance biomaterial design and application; in situ tissue repair with targeted therapies; and applying the principles of normal developmental biology to regenerative medicine or stem cell based tissue engineering. SC BioCRAFT accomplishments towards these three translational goals include the recruitment of 10 new faculty, mentoring and training of 23 COBRE target faculty, and the development of two research core facilities. Programmatic outcomes include 26 independent NIH research awards, 62 research awards from other agencies to target faculty, and >550 peer reviewed publications. South Carolina Centers of Economic Excellence: SmartState awarded three endowed chairs in Regenerative Medicine and Advanced Tissue Biofabrication in partnerships with Clemson and the University of South Carolina. SC BioCRAFT participated in the successful renewal of a statewide INBRE award with a focus on bioengineering/regenerative medicine. For this P30 application, the plan transitioning to independence of NIH/NIGMS support during the next five years is to enhance and upgrade our core technologies, to increase their competitiveness, to attract greater usage (and cost recovery), and to promote new research collaborations with our Center that can lead to submission of competitive research applications and broaden our statewide outreach, especially to other IDeA centers. A seven step, five-year strategic plan including implementing fee structures, pilot projects/voucher program, outreach activities and programmatic development is proposed to sustain the SC BioCRAFT/COBRE center and its scientific cores (Biomaterials Engineering and Testing and Translational Research Imaging). The founding director of Clemson's SC BioCRAFT COBRE will lead the Administrative Core and will be assisted by two outstanding scientists from Medical University of South Carolina who have themselves directed COBREs. Together, these three leaders will act as the main operational arm of the Center. An External Advisory Committee will provide ongoing assessment and evaluation of the Center's progress. Institutional commitments from the Vice President for Research, ~2 million dollars, will help ensure programmatic growth development and long- term sustainability of the Center.