Bioengineering Center for Regeneration and Formation of Tissues (SC BioCRAFT)
组织再生与形成生物工程中心 (SC BioCRAFT)
基本信息
- 批准号:10457960
- 负责人:
- 金额:$ 114.29万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:Advisory CommitteesAffectAllograftingAreaAutologousAwardBasic ScienceBehaviorBiocompatible MaterialsBiomaterials ResearchBiomedical EngineeringBone TissueCapitalCardiovascular DiseasesCardiovascular systemCenters of Research ExcellenceClinicalCollaborationsCore FacilityDataDevelopmentDevelopmental BiologyDiabetes MellitusDisadvantagedDiseaseEconomicsEngineeringEnsureEquipmentEvaluationExtramural ActivitiesFacultyFeesFosteringFundingFutureGoalsGrowth and Development functionHealthImageIn SituIndividualInfrastructureKnowledgeLeadLeadershipLearningLifeMedicalMedicineMentorsMethodsMissionMorbidity - disease rateNational Institute of General Medical SciencesNatural regenerationNatureObesityOrgan failureOrganismOutcomePeer ReviewPhasePhysiologyPilot ProjectsPopulationPositioning AttributeProsthesisPublicationsRecoveryRegenerative MedicineResearchResearch InfrastructureResearch PersonnelResourcesScientistSouth CarolinaStrategic PlanningStrokeStructureTeacher Professional DevelopmentTechnical ExpertiseTechnologyTestingTissue EngineeringTissuesTrainingTranslational ResearchTranslationsUnited States National Institutes of HealthUniversitiesXenograft procedurearmbasebiofabricationbioimagingcareerclinical applicationclinically relevantcostdesigndisabilityfaculty mentorfaculty researchhuman diseaseimprovedinnovationinterdisciplinary collaborationinterestmembermortalitymultidisciplinarynoveloutreachprogram costsprogramsranpirnaserecruitrelating to nervous systemstem cellssuccesssynergismtargeted treatmenttissue regenerationtissue repairtranslational goalvoucher
项目摘要
This COBRE Phase III application is aimed at sustaining the research infrastructure built during the first ten years
of NIGMS funding. Our COBRE “South Carolina Bioengineering Center for Regeneration and Formation of
Tissues” has become a nationally recognized, collaborative center with unique strengths in bioengineering
approaches to regenerative medicine. Three underlying themes define the Center's research: advance
biomaterial design and application; in situ tissue repair with targeted therapies; and applying the principles of
normal developmental biology to regenerative medicine or stem cell based tissue engineering. SC BioCRAFT
accomplishments towards these three translational goals include the recruitment of 10 new faculty, mentoring
and training of 23 COBRE target faculty, and the development of two research core facilities. Programmatic
outcomes include 26 independent NIH research awards, 62 research awards from other agencies to target
faculty, and >550 peer reviewed publications. South Carolina Centers of Economic Excellence: SmartState
awarded three endowed chairs in Regenerative Medicine and Advanced Tissue Biofabrication in partnerships
with Clemson and the University of South Carolina. SC BioCRAFT participated in the successful renewal of a
statewide INBRE award with a focus on bioengineering/regenerative medicine.
For this P30 application, the plan transitioning to independence of NIH/NIGMS support during the next five years
is to enhance and upgrade our core technologies, to increase their competitiveness, to attract greater usage
(and cost recovery), and to promote new research collaborations with our Center that can lead to submission of
competitive research applications and broaden our statewide outreach, especially to other IDeA centers. A seven
step, five-year strategic plan including implementing fee structures, pilot projects/voucher program, outreach
activities and programmatic development is proposed to sustain the SC BioCRAFT/COBRE center and its
scientific cores (Biomaterials Engineering and Testing and Translational Research Imaging). The founding
director of Clemson's SC BioCRAFT COBRE will lead the Administrative Core and will be assisted by two
outstanding scientists from Medical University of South Carolina who have themselves directed COBREs.
Together, these three leaders will act as the main operational arm of the Center. An External Advisory Committee
will provide ongoing assessment and evaluation of the Center's progress. Institutional commitments from the
Vice President for Research, ~2 million dollars, will help ensure programmatic growth development and long-
term sustainability of the Center.
COBRE第三阶段的应用旨在维持前十年建立的研究基础设施
NIGMS的资金。我们的COBRE“南卡罗来纳州生物工程中心的再生和形成
组织”已成为一个全国公认的,在生物工程方面具有独特优势的合作中心
再生医学的方法三个基本主题定义了该中心的研究:
生物材料设计和应用;原位组织修复与靶向治疗;并应用的原则,
正常发育生物学到再生医学或基于干细胞的组织工程。SC BioCRAFT
实现这三个转化目标的成就包括招聘10名新教师,指导
培训23名COBRE目标教师,并开发两个研究核心设施。纲领性
结果包括26个独立的NIH研究奖,62个来自其他机构的研究奖,
教师,和>550同行评审的出版物。南卡罗来纳州经济卓越中心:SmartState
授予再生医学和先进组织生物制品的三个捐赠椅子的合作伙伴关系
与克莱姆森和南卡罗来纳州大学合作。SC BioCRAFT参与了一个成功的更新,
全州范围内的INBRE奖,重点是生物工程/再生医学。
对于此P30应用程序,计划在未来五年内过渡到NIH/NIGMS支持的独立性
是加强和提升我们的核心技术,提高它们的竞争力,吸引更多的使用,
(and成本回收),并促进与我们中心的新的研究合作,可以导致提交
竞争力的研究应用,并扩大我们的全州范围,特别是其他IDEA中心。一个七
步骤、五年战略计划,包括实施收费结构、试点项目/代金券方案、推广
提出了一些活动和项目发展的建议,以维持SC BioCRAFT/COBRE中心及其
科学核心(生物材料工程和测试以及转化研究成像)。成立
克莱姆森的SC生物工艺COBRE主任将领导行政核心,并由两名
来自南卡罗来纳州医科大学的杰出科学家,他们亲自指导了COBREs。
这三位领导人将共同担任该中心的主要业务部门。外部咨询委员会
将对中心的进展情况进行持续的评估和评价。联合国的机构承诺
研究副总裁,约200万美元,将有助于确保方案的发展和长期的增长,
中心的可持续性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Naren R Vyavahare', 18)}}的其他基金
Pulmonary valved conduit xenograft with regeneration potential
具有再生潜力的肺动脉瓣导管异种移植物
- 批准号:
10086830 - 财政年份:2020
- 资助金额:
$ 114.29万 - 项目类别:
Medial Arterial Calcification: Mechanisms and Therapy
内侧动脉钙化:机制和治疗
- 批准号:
10517640 - 财政年份:2019
- 资助金额:
$ 114.29万 - 项目类别:
Bioengineering Center of Regeneration and Formation of Tissues (SC BioCRAFT)
组织再生与形成生物工程中心(SC BioCRAFT)
- 批准号:
10400406 - 财政年份:2019
- 资助金额:
$ 114.29万 - 项目类别:
Bioengineering Center for Regeneration and Formation of Tissues (SC BioCRAFT)
组织再生与形成生物工程中心 (SC BioCRAFT)
- 批准号:
10670143 - 财政年份:2019
- 资助金额:
$ 114.29万 - 项目类别:
Medial Arterial Calcification: Mechanisms and Therapy
内侧动脉钙化:机制和治疗
- 批准号:
10304908 - 财政年份:2019
- 资助金额:
$ 114.29万 - 项目类别:
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