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Bioengineering Center for Regeneration and Formation of Tissues (SC BioCRAFT)

组织再生与形成生物工程中心 (SC BioCRAFT)

基本信息

批准号：
10670143
负责人：
Naren R Vyavahare
金额：
$ 114.29万
依托单位：
CLEMSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10670143
关键词：
Advisory Committees Affect Allografting Area Autologous Award Basic Science Behavior Biocompatible Materials Biomaterials Research Biomedical Engineering Bone Tissue Capital Cardiovascular Diseases Cardiovascular system Centers of Research Excellence Clinical Collaborations Core Facility Data Development Developmental Biology Diabetes Mellitus Disadvantaged Disease Economics Endowment Engineering Ensure Equipment Evaluation Extramural Activities Faculty Fees Fostering Funding Future Goals Growth and Development function Health Image In Situ Individual Infrastructure Institution Knowledge Lead Leadership Learning Life Medical Medicine Mentors Methods Mission Morbidity - disease rate National Institute of General Medical Sciences Natural regeneration Nature Obesity Organ failure Organism Outcome Peer Review Phase Physiology Pilot Projects Population Positioning Attribute Prosthesis Publications Recovery Regenerative Medicine Research Research Infrastructure Research Personnel Resources Scientist South Carolina Strategic Planning Stroke Structure Technical Expertise Technology Testing Tissue Engineering Tissues Training Translational Research Translations United States National Institutes of Health Universities Xenograft procedure arm biofabrication bioimaging career clinical application clinically relevant cost design disability equipment acquisition faculty research fortification human disease improved innovation inter-institutional interdisciplinary collaboration interest member mortality multidisciplinary neural novel outreach program costs programs recruit stem cells success synergism targeted treatment tissue regeneration tissue repair translational goal voucher

项目摘要

This COBRE Phase III application is aimed at sustaining the research infrastructure built during the first ten years of NIGMS funding. Our COBRE “South Carolina Bioengineering Center for Regeneration and Formation of Tissues” has become a nationally recognized, collaborative center with unique strengths in bioengineering approaches to regenerative medicine. Three underlying themes define the Center's research: advance biomaterial design and application; in situ tissue repair with targeted therapies; and applying the principles of normal developmental biology to regenerative medicine or stem cell based tissue engineering. SC BioCRAFT accomplishments towards these three translational goals include the recruitment of 10 new faculty, mentoring and training of 23 COBRE target faculty, and the development of two research core facilities. Programmatic outcomes include 26 independent NIH research awards, 62 research awards from other agencies to target faculty, and >550 peer reviewed publications. South Carolina Centers of Economic Excellence: SmartState awarded three endowed chairs in Regenerative Medicine and Advanced Tissue Biofabrication in partnerships with Clemson and the University of South Carolina. SC BioCRAFT participated in the successful renewal of a statewide INBRE award with a focus on bioengineering/regenerative medicine. For this P30 application, the plan transitioning to independence of NIH/NIGMS support during the next five years is to enhance and upgrade our core technologies, to increase their competitiveness, to attract greater usage (and cost recovery), and to promote new research collaborations with our Center that can lead to submission of competitive research applications and broaden our statewide outreach, especially to other IDeA centers. A seven step, five-year strategic plan including implementing fee structures, pilot projects/voucher program, outreach activities and programmatic development is proposed to sustain the SC BioCRAFT/COBRE center and its scientific cores (Biomaterials Engineering and Testing and Translational Research Imaging). The founding director of Clemson's SC BioCRAFT COBRE will lead the Administrative Core and will be assisted by two outstanding scientists from Medical University of South Carolina who have themselves directed COBREs. Together, these three leaders will act as the main operational arm of the Center. An External Advisory Committee will provide ongoing assessment and evaluation of the Center's progress. Institutional commitments from the Vice President for Research, ~2 million dollars, will help ensure programmatic growth development and long- term sustainability of the Center.

此Cobre第三阶段应用程序旨在支持在最初十年中建立的研究基础设施 NIGMS的资金来源。我们的科布雷“南卡罗来纳州生物工程中心再生和形成已成为全国公认的生物工程合作中心，具有独特的优势。再生医学的方法。三个基本主题定义了该中心的研究：先进生物材料的设计和应用；靶向治疗的原位组织修复；以及应用从正常发育生物学到再生医学或基于干细胞的组织工程。SC BioCRAFT 实现这三个翻译目标的成就包括招聘10名新教师、指导并培训了23名Cobre目标教师，并开发了两个研究核心设施。程序性的结果包括26个独立的NIH研究奖项，62个来自其他机构的研究奖项教师，以及550种同行评审的出版物。南卡罗来纳州经济卓越中心：SmartState 在伙伴关系中获得再生医学和先进组织生物制造领域的三名捐赠教授克莱姆森和南卡罗来纳大学。SC BioCRAFT参与成功续签了全州INBRE奖，重点是生物工程/再生医学。对于此P30应用程序，计划在未来五年过渡到独立于NIH/NIGMS支持就是要加强和提升我们的核心技术，增加它们的竞争力，吸引更多的人使用 (和成本回收)，并促进与我们中心的新研究合作，这可能导致提交具有竞争力的研究应用程序，并扩大我们在全州范围内的覆盖范围，特别是到其他创意中心。A 7 五年战略计划，包括实施收费结构、试点项目/代金券计划、推广建议开展活动和制定方案，以支持SC BioCRAFT/Cobre中心及其科学核心(生物材料工程与测试和翻译研究成像)。开国大业克莱姆森SC BioCRAFT的主管科布雷将领导行政核心，并将由两名来自南卡罗来纳医科大学的杰出科学家，他们自己执导了科布尔斯。这三位领导人将共同担任该中心的主要业务部门。外部咨询委员会将对中心的进展情况进行持续评估和评价。世界银行的机构承诺负责研究的副总裁，约200万美元，将帮助确保方案增长发展和长期- 中心的长期可持续性。