Dementia Determinants in Caribbean and U.S. Hispanics

项目摘要/摘要 加勒比海和美国拉美裔人口中的痴呆症决定因素 这项针对PAR-17-470的建议将大大扩展对以下方面的认识 加勒比裔人群中的痴呆症决定因素和后果。我们建立在 10/66痴呆症研究小组在首都大都市进行的国际协调调查 波多黎各、多米尼加共和国和古巴的地区；这三个岛屿/国家是 绝大多数加勒比移民到美国的来源地。我们将比较这些数据 与美国健康和退休研究，特别是其健康认知老龄化项目 (HCAP)为此类痴呆症国际比较而设计的一项子研究。10/66 数据显示，在这些地区65岁以上的成年人中，痴呆症的患病率非常高，为10%-12% 三个加勒比海遗址，它们的历史相似，但过去的社会结构千差万别 世纪为更好地了解加勒比海裔移民痴呆症提供了巨大的希望 人口。我们的国际协作团队将专注于三个具体目标：(1)收集 非大都市波多黎各和多米尼加共和国的新基线调查数据平行 现有的10/66样本来自首都地区，以更好地捕捉生活过程中的变化 这些发送国/国家的曝光率。(2)分析痴呆症与 假设的不同背景下的生命周期社会经济决定因素，利用比较 跨越极其不同的生活环境，以了解痴呆症的驱动因素 并模拟在社会变化的情况下，流行率可能会如何看似不同 情况。(3)分析痴呆症的比较社会成本(包括正式和非正式的 和非正式护理)，以模拟这些成本在更改后可能会如何合理地不同 社会安排。

PROJECT SUMMARY/ABSTRACT “Dementia Determinants in Caribbean and U.S. Hispanic Populations” This proposal in response to PAR-17-470 will significantly expand knowledge regarding dementia determinants and consequences in Caribbean-origin populations. We build on the 10/66 Dementia Research Group’s internationally harmonized surveys in capital city metro areas of Puerto Rico, Dominican Republic, and Cuba; these three islands/countries are the origin of the vast majority of Caribbean immigrants to the U.S. We will compare these data with the U.S. Health and Retirement Study, and particularly its Healthy Cognitive Aging Project (HCAP) sub-study which was designed for such international comparisons of dementia. 10/66 data indicate a remarkably high dementia prevalence of 10-12% among adults ages 65+ in these three Caribbean sites, whose similar histories but richly varying societal structures over the past century offer great promise for better understanding dementia in Caribbean-origin immigrant populations. Our international collaborative team will focus on three specific aims: (1) Collect new baseline survey data in non-metro Puerto Rico and Dominican Republic that parallel existing 10/66 samples from capital city areas, to better capture the variation in lifecourse exposures in these sending islands/countries. (2) Analyze dementia relationships with hypothesized lifecourse socioeconomic determinants across contexts, exploiting comparisons across vastly heterogeneous life circumstances to both understand drivers of dementia prevalence and to simulate how prevalence could plausibly be different under altered social circumstances. (3) Analyze the comparative societal costs of dementia (including both formal and informal care) to simulate how these costs could plausibly be different under altered societal arrangements.