Dementia Determinants in Caribbean and U.S. Hispanics

加勒比海地区和美国西班牙裔痴呆症的决定因素

• 批准号: 10404335
• 负责人: William Hatfield Dow
• 金额: $ 14.78万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10404335
• 关键词: Adult; Age; Apolipoprotein E; Area; Baseline Surveys; Behavioral; Biological Assay; Biological Markers; Blood Pressure; Blood specimen; Capital; Caribbean Hispanic; Caribbean region; Caring; Characteristics; Cholesterol; Cities; Cognitive aging; Complement; Country; Cuba; Data; Dementia; Dominican Republic; Elderly; Ethnic group; Freezing; Funding; Future; Generations; Genetic; Geography; Glycosylated hemoglobin A; Hand Strength; Health; Health and Retirement Study; Healthcare; Height; Hispanics; Household; Human Resources; Immigrant; International; Interview; Island; Knowledge; Life; Modeling; Outcome; Pattern; Population; Prevalence; Puerto Rico; Recording of previous events; Research; Risk Factors; Rural; Rural Population; Sample Size; Sampling; Sex Differences; Shapes; Site; Socioeconomic Status; Structure; Surveys; Testing; Time; Urban Population; Variant; Walking; Weight; West Indies; Work; base; care costs; caregiving; comparative; cost; dementia care; demographics; design; experience; fasting glucose; health care service utilization; improved; informal care; informal caregiving; instrumental activity of daily living; public health relevance; residence; response; sex; social; societal costs; socioeconomics; waist circumference

PROJECT SUMMARY/ABSTRACT “Dementia Determinants in Caribbean and U.S. Hispanic Populations” This proposal in response to PAR-17-470 will significantly expand knowledge regarding dementia determinants and consequences in Caribbean-origin populations. We build on the 10/66 Dementia Research Group’s internationally harmonized surveys in capital city metro areas of Puerto Rico, Dominican Republic, and Cuba; these three islands/countries are the origin of the vast majority of Caribbean immigrants to the U.S. We will compare these data with the U.S. Health and Retirement Study, and particularly its Healthy Cognitive Aging Project (HCAP) sub-study which was designed for such international comparisons of dementia. 10/66 data indicate a remarkably high dementia prevalence of 10-12% among adults ages 65+ in these three Caribbean sites, whose similar histories but richly varying societal structures over the past century offer great promise for better understanding dementia in Caribbean-origin immigrant populations. Our international collaborative team will focus on three specific aims: (1) Collect new baseline survey data in non-metro Puerto Rico and Dominican Republic that parallel existing 10/66 samples from capital city areas, to better capture the variation in lifecourse exposures in these sending islands/countries. (2) Analyze dementia relationships with hypothesized lifecourse socioeconomic determinants across contexts, exploiting comparisons across vastly heterogeneous life circumstances to both understand drivers of dementia prevalence and to simulate how prevalence could plausibly be different under altered social circumstances. (3) Analyze the comparative societal costs of dementia (including both formal and informal care) to simulate how these costs could plausibly be different under altered societal arrangements.

项目概要/摘要 “加勒比海地区和美国西班牙裔人口的痴呆症决定因素” 这项针对 PAR-17-470 的提案将显着扩展有关以下方面的知识： 加勒比原住民痴呆症的决定因素和后果。我们建立在 10/66 痴呆症研究小组在首都地铁进行的国际统一调查 波多黎各、多米尼加共和国和古巴地区；这三个岛屿/国家是 绝大多数加勒比移民到美国的来源 我们将比较这些数据 与美国健康和退休研究，特别是其健康认知老龄化项目 (HCAP) 子研究是为痴呆症的国际比较而设计的。 10/66 数据表明，这些地区 65 岁以上成年人的痴呆症患病率非常高，达到 10-12% 三个加勒比遗址，其历史相似，但过去的社会结构却截然不同 世纪为更好地了解加勒比裔移民的痴呆症提供了巨大希望 人口。我们的国际合作团队将专注于三个具体目标：（1）收集 非都市波多黎各和多米尼加共和国的新基线调查数据与 现有首都城市地区的10/66样本，以更好地捕捉生命历程的变化 这些发送岛屿/国家的暴露。 (2) 分析痴呆的关系 利用比较，假设不同背景下的生命历程社会经济决定因素 跨越多种多样的生活环境，以了解痴呆症的驱动因素 流行率并模拟在社会变化的情况下流行率如何可能有所不同 情况。 (3) 分析痴呆症的相对社会成本（包括正式的 和非正式护理）来模拟这些成本在改变的情况下如何可能有所不同 社会安排。