权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Dementia Determinants in Caribbean and U.S. Hispanics

加勒比海地区和美国西班牙裔痴呆症的决定因素

基本信息

批准号：
10586105
负责人：
William Hatfield Dow
金额：
$ 58.4万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10586105
关键词：
Adult Age Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Apolipoprotein E Area Baseline Surveys Behavioral Biological Assay Biological Markers Blood Pressure Blood specimen Capital Caribbean Hispanic Caribbean region Caring Characteristics Cholesterol Cities Cognitive aging Complement Country Cuba Data Dementia Dominican Republic Elderly Ethnic Population Freezing Funding Future Generations Genetic Geography Glycosylated hemoglobin A Hand Strength Health Health and Retirement Study Healthcare Height Hispanic Hispanic Populations Household Human Resources Immigrant International Interview Island Knowledge Life Life Cycle Stages Modeling Outcome Pattern Population Prevalence Puerto Rico Recording of previous events Research Risk Factors Rural Rural Population Sample Size Sampling Sex Differences Shapes Site Socioeconomic Status Structure Surveys Testing Time Urban Population Variant Walking Weight West Indies Work care costs caregiving comparative cost dementia care demographics design economic determinant experience fasting glucose health care service utilization improved informal care informal caregiving instrumental activity of daily living public health relevance residence response sex social societal costs socioeconomics waist circumference

项目摘要

PROJECT SUMMARY/ABSTRACT “Dementia Determinants in Caribbean and U.S. Hispanic Populations” This proposal in response to PAR-17-470 will significantly expand knowledge regarding dementia determinants and consequences in Caribbean-origin populations. We build on the 10/66 Dementia Research Group’s internationally harmonized surveys in capital city metro areas of Puerto Rico, Dominican Republic, and Cuba; these three islands/countries are the origin of the vast majority of Caribbean immigrants to the U.S. We will compare these data with the U.S. Health and Retirement Study, and particularly its Healthy Cognitive Aging Project (HCAP) sub-study which was designed for such international comparisons of Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD). 10/66 data indicate a remarkably high dementia prevalence of 10-12% among adults ages 65+ in these three Caribbean sites, whose similar histories but richly varying societal structures over the past century offer great promise for better understanding AD/ADRD in Caribbean-origin immigrant populations. Our international collaborative team will focus on three specific aims: (1) Collect new baseline survey data in non-metro Puerto Rico and Dominican Republic that parallel existing 10/66 samples from capital city areas, to better capture the variation in lifecourse exposures in these sending islands/countries. (2) Analyze AD/ADRD relationships with hypothesized lifecourse socioeconomic determinants across contexts, exploiting comparisons across vastly heterogeneous life circumstances to both understand drivers of AD/ADRD prevalence and to simulate how prevalence could plausibly be different under altered social circumstances. (3) Analyze the comparative societal costs of AD/ADRD (including both formal and informal care) to simulate how these costs could plausibly be different under altered societal arrangements.

项目概要/摘要“加勒比海和美国西班牙裔人群中的痴呆症决定因素”这一响应PAR-17-470的提案将显著扩大有关加勒比海裔人群中痴呆症决定因素和后果的知识。我们建立在10/66痴呆症研究小组在波多黎各，多米尼加共和国和古巴首都大都市地区的国际统一调查基础上;这三个岛屿/国家是绝大多数加勒比移民到美国的起源。我们将这些数据与美国健康和退休研究进行比较，特别是其健康认知老化项目（HCAP）子研究，该研究是为阿尔茨海默病和阿尔茨海默病相关痴呆（AD/ADRD）的国际比较而设计的。10/66的数据表明，在这三个加勒比地区的65岁以上的成年人中，痴呆症的患病率非常高，为10-12%，在过去的世纪，其相似的历史，但丰富多样的社会结构提供了更好地了解AD/ADRD在加勒比裔移民人口的巨大希望。我们的国际合作团队将专注于三个具体目标：（1）在非都市波多黎各和多米尼加共和国收集新的基线调查数据，与首都地区现有的10/66样本平行，以更好地捕捉这些发送岛屿/国家的生活过程暴露的变化。(2)分析AD/ADRD与不同背景下假设的生活过程社会经济决定因素的关系，利用各种不同生活环境的比较，以了解AD/ADRD患病率的驱动因素，并模拟患病率在改变的社会环境下可能会有什么不同。(3)分析AD/ADRD（包括正式和非正式护理）的比较社会成本，以模拟这些成本在改变的社会安排下可能会有什么不同。