Dementia Determinants in Caribbean and U.S. Hispanics

加勒比海地区和美国西班牙裔痴呆症的决定因素

基本信息

批准号：
10586105
负责人：
William Hatfield Dow
金额：
$ 58.4万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10586105
关键词：
Adult Age Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Apolipoprotein E Area Baseline Surveys Behavioral Biological Assay Biological Markers Blood Pressure Blood specimen Capital Caribbean Hispanic Caribbean region Caring Characteristics Cholesterol Cities Cognitive aging Complement Country Cuba Data Dementia Dominican Republic Elderly Ethnic Population Freezing Funding Future Generations Genetic Geography Glycosylated hemoglobin A Hand Strength Health Health and Retirement Study Healthcare Height Hispanic Hispanic Populations Household Human Resources Immigrant International Interview Island Knowledge Life Life Cycle Stages Modeling Outcome Pattern Population Prevalence Puerto Rico Recording of previous events Research Risk Factors Rural Rural Population Sample Size Sampling Sex Differences Shapes Site Socioeconomic Status Structure Surveys Testing Time Urban Population Variant Walking Weight West Indies Work care costs caregiving comparative cost dementia care demographics design economic determinant experience fasting glucose health care service utilization improved informal care informal caregiving instrumental activity of daily living public health relevance residence response sex social societal costs socioeconomics waist circumference

项目摘要

PROJECT SUMMARY/ABSTRACT “Dementia Determinants in Caribbean and U.S. Hispanic Populations” This proposal in response to PAR-17-470 will significantly expand knowledge regarding dementia determinants and consequences in Caribbean-origin populations. We build on the 10/66 Dementia Research Group’s internationally harmonized surveys in capital city metro areas of Puerto Rico, Dominican Republic, and Cuba; these three islands/countries are the origin of the vast majority of Caribbean immigrants to the U.S. We will compare these data with the U.S. Health and Retirement Study, and particularly its Healthy Cognitive Aging Project (HCAP) sub-study which was designed for such international comparisons of Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD). 10/66 data indicate a remarkably high dementia prevalence of 10-12% among adults ages 65+ in these three Caribbean sites, whose similar histories but richly varying societal structures over the past century offer great promise for better understanding AD/ADRD in Caribbean-origin immigrant populations. Our international collaborative team will focus on three specific aims: (1) Collect new baseline survey data in non-metro Puerto Rico and Dominican Republic that parallel existing 10/66 samples from capital city areas, to better capture the variation in lifecourse exposures in these sending islands/countries. (2) Analyze AD/ADRD relationships with hypothesized lifecourse socioeconomic determinants across contexts, exploiting comparisons across vastly heterogeneous life circumstances to both understand drivers of AD/ADRD prevalence and to simulate how prevalence could plausibly be different under altered social circumstances. (3) Analyze the comparative societal costs of AD/ADRD (including both formal and informal care) to simulate how these costs could plausibly be different under altered societal arrangements.

该提案对PAR-17-470的响应项目摘要/摘要“加勒比海和美国西班牙裔人口中的痴呆症决定因素”将大大扩大有关痴呆症决定者的知识和加勒比海地区的后果的知识。我们以10/66痴呆症研究小组在波多黎各，多米尼加共和国和古巴的10/66痴呆症研究小组的国际协调调查为基础。这三个岛屿/国家是美国绝大多数加勒比海移民的起源，我们将将这些数据与美国健康和退休研究进行比较，尤其是其健康的认知衰老项目（HCAP）子研究，该研究旨在与阿尔茨海默氏病和阿尔茨海默氏病有关的与阿尔茨海默氏病有关的国际比较。 10/66的数据表明，在这三个加勒比海地点，65岁以上的成年人的痴呆症患病率非常高10-12％，在过去的一个世纪中，在过去的世纪中，其相似的历史但富有变化的社会结构为更好地理解加勒比海 - 奥里根蛋白移民种群的AD/ADRD提供了巨大的希望。我们的国际合作团队将重点关注三个具体目标：（1）在非墨西哥港和多米尼加共和国收集新的基线调查数据，这些数据与首都城地区的现有10/66样本平行，以更好地捕获这些发送岛屿/国家的生命式风险差异。（2）分析与假设的生命性社会经济决定者的AD/ADRD关系，从而利用了广泛异构的生活环境的比较，以了解AD/ADRD普遍存在的驱动因素，并模拟在社会环境中可能会有不同的普遍性。（3）分析AD/ADRD的比较社会成本（包括正式和非正式护理），以模拟这些成本在改变的社会安排下如何可能有所不同。