Cognitive, socioaffective, and neural development following fetal Zika virus infection

项目摘要 在最极端的情况下，胎儿感染寨卡病毒会导致小头畸形--胎儿大脑的显著萎缩 还有骷髅头。越来越多的证据表明，小头畸形只是胎儿寨卡病毒可能导致的后果之一 然而，感染，出生时头部大小正常的婴儿可能有重要的中枢神经系统 病理学。这种病理的长期后果尚不清楚，留下了一种可能性 由认知和社会情感过程受损引起的继发性流行病，将作为 在流行时期出生的婴儿。这项补充的拟议工作通过以下方式增加了家长补助金 评估这种病理对一群儿童感觉运动发育的影响 非人灵长类作为胎儿感染寨卡病毒与一组程序匹配，未感染 控制。我们将评估母体和胎儿病毒血症对行为和神经的影响程度 感觉运动功能的测量。因为猕猴的发育速度大约是人类的四倍， 我们将能够前瞻性地模拟产生的病理--也就是说，我们将能够预测什么病理 在2015-2016年寨卡疫情期间感染寨卡病毒的人类婴儿，将随着他们的成长而经历。 这类发展模型对于开发有效的干预和治疗方法至关重要 鼓励健康发展，改善精神病态。通过这一补充提供的资金将支持 对具有以下背景的学者进行的博士生培训：这些背景在中国的代表性较低，而且通常被排除在 茎。

Project Summary At its most extreme, fetal Zika virus infection causes microcephaly – the significant shrinking of the fetal brain and skull. Accumulating evidence suggests that microcephaly is just one possible outcome of fetal Zika virus infection, however, and that babies born with normal sized heads may have significant central nervous system pathology. The long-term consequences of this pathology are unknown, leaving open the possibility of a secondary epidemic resulting from compromised cognition and socioaffective processing that will occur as babies born during the epidemic age. The proposed work for this supplement augments the Parent Grant by carrying out evaluations of the consequences of this pathology on sensorimotor development of a cohort of nonhuman primates infected with Zika virus as fetuses and a group of procedure matched, non-infected controls. We will evaluate the extent to which maternal and fetal viremia influences behavioral and neural measures of sensorimotor function. Because macaques develop approximately four times faster than humans, we will be able to prospectively model pathology that arises – that is, we will be able to predict what pathology human babies, infected with Zika virus during the 2015-2016 epidemic, will experience as they grow up. Developmental modeling of this sort is critical for developing effective interventions and treatments to encourage healthy development and ameliorate psychopathology. Funding via this supplement will support the doctoral training of a scholar from a background that is underrepresented in, and typically excluded from, STEM.