Cognitive, socioaffective, and neural development following fetal Zika virus infection

项目摘要 在最极端的情况下，胎儿寨卡病毒感染会导致小头畸形--胎儿大脑的显著萎缩 还有头骨越来越多的证据表明，小头畸形症只是胎儿寨卡病毒的一种可能结果。 然而，感染，以及出生时头部大小正常的婴儿可能具有重要的中枢神经系统 病理这种病理学的长期后果尚不清楚，留下了一种可能性， 由于认知和社会情感处理受损而导致的继发性流行病， 在流行病时期出生的婴儿。这项补充的拟议工作增加了父母补助金， 进行这种病理学对一组儿童感觉运动发育的后果的评价， 非人灵长类动物感染寨卡病毒作为胎儿和一组程序匹配，非感染 对照我们将评估母体和胎儿病毒血症影响行为和神经功能的程度。 感觉运动功能的测量。因为猕猴的发育速度大约是人类的四倍， 我们将能够前瞻性地模拟出现的病理-也就是说，我们将能够预测什么病理 在2015-2016年流行期间感染寨卡病毒的人类婴儿在成长过程中将经历的经历。 这种发展模型对于开发有效的干预和治疗至关重要， 促进健康发展和改善精神病理学。通过这一补充资金将支持 博士培训的学者从一个背景是代表性不足，通常被排除在外， 茎

Project Summary At its most extreme, fetal Zika virus infection causes microcephaly – the significant shrinking of the fetal brain and skull. Accumulating evidence suggests that microcephaly is just one possible outcome of fetal Zika virus infection, however, and that babies born with normal sized heads may have significant central nervous system pathology. The long-term consequences of this pathology are unknown, leaving open the possibility of a secondary epidemic resulting from compromised cognition and socioaffective processing that will occur as babies born during the epidemic age. The proposed work for this supplement augments the Parent Grant by carrying out evaluations of the consequences of this pathology on sensorimotor development of a cohort of nonhuman primates infected with Zika virus as fetuses and a group of procedure matched, non-infected controls. We will evaluate the extent to which maternal and fetal viremia influences behavioral and neural measures of sensorimotor function. Because macaques develop approximately four times faster than humans, we will be able to prospectively model pathology that arises – that is, we will be able to predict what pathology human babies, infected with Zika virus during the 2015-2016 epidemic, will experience as they grow up. Developmental modeling of this sort is critical for developing effective interventions and treatments to encourage healthy development and ameliorate psychopathology. Funding via this supplement will support the doctoral training of a scholar from a background that is underrepresented in, and typically excluded from, STEM.