A TRANSLATIONAL MODEL OF HEALTHY SOCIOEMOTIONAL AGING

健康社会情感老龄化的转化模型

• 批准号: 9508876
• 负责人: Eliza Bliss-Moreau
• 金额: $ 23.16万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9508876
• 关键词: 12 year old; 20 year old; Adult; Affect; Affective; Age; Age-Years; Aging; Animal Behavior; Animal Model; Animals; Anxiety; Attention; Autonomic nervous system; Behavior; Biological; Biological Markers; Biological Process; Cognitive aging; Complex; Data; Deterioration; Development; Elderly; Electrocardiogram; Emotional; Eye; Face; Foundations; Funding; Future; Goals; Health; Health Promotion; Human; Intervention; Investigation; Investments; Laboratories; Life; Longitudinal Studies; Macaca; Macaca mulatta; Mathematics; Memory; Modeling; Monkeys; Neuroanatomy; Pattern; Peripheral; Personal Satisfaction; Physiology; Procedures; Process; Psychopathology; Reporting; Research; Resources; Sinus Arrhythmia; Social Behavior; Social Environment; Social Interaction; Stimulus; Stress; System; Testing; United States; United States National Institutes of Health; Uterus; Visual attention; Work; age related; aged; aging population; attentional bias; behavior observation; cohort; effective intervention; effective therapy; electric impedance; emotional experience; experience; experimental study; healthy aging; human model; indexing; innovation; memory process; middle age; nonhuman primate; predictive marker; psychologic; respiratory; response; social; translational model; young adult

Project Summary By 2060, there will be at least 98 million older adults (65 years of age or older) living in the United States (Colby & Ortman, 2014), underscoring the urgency to understand the biological processes that drive healthy, “successful” aging. While aging is accompanied by a host of negative changes (e.g., deterioration of memory), paradoxically, existing data demonstrate that social and emotional life actually get better with age. Older adults report more positive social experiences, more positive and/or less negative emotional experiences, and have biased attention towards positive and away from negative stimuli (e.g., Birditt et al., 2005; 2009; Luong et al., 2011; Gross et al., 1997; Carstensen et al., 2011; Isaacowitz et al., 2006a,b; Isaacowitz et al., 2008; Isaacowitz, 2012; Mather & Carstensen, 2003). This phenomenon is known as the “positivity effect” (Mather & Carstensen, 2005; Carstensen & Mikels, 2005). The goal of the proposed research is to take the first step in understanding the biological mechanisms that generate this “positivity effect” by establishing an animal model of healthy human socioemotional aging with the understanding that we must understand health to treat those who are not healthy. To that end, a suite of tests homologous to those used with humans will be used to evaluate socioemotional processes in rhesus macaques, and the translational relevance of those tests will be determined on a task-by-task basis. The proposed work will evaluate the social behavior of the animals, visual attention to positive and negative stimuli, and features of emotional responding associated with activity in the autonomic nervous system. The goal of the proposed research – to establish rhesus monkeys as a model for healthy socioemotional aging in humans – serves the long-term goal of understanding the biological mechanisms that support healthy socioemotional aging, which in turn will enable development of effective treatments and interventions to promote health and well-being in our aging population.

项目总结