Individual differences in early autonomic nervous system activity

早期自主神经系统活动的个体差异

• 批准号: 9189642
• 负责人: Eliza Bliss-Moreau
• 金额: $ 25.07万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-12-04 至 2018-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9189642
• 关键词: Adult; Affect; Affective; Age-Months; Animal Model; Autonomic nervous system; Behavior; Behavioral; Biological; Biological Markers; Biology; C-reactive protein; Cardiac; Childhood; Data; Data Collection; Development; Electrocardiogram; Emotional; Ensure; Environment; Funding; Genotype; Goals; Health; Homeostasis; Human; Hydrocortisone; Individual; Individual Differences; Infant; Intervention; Knowledge; Laboratories; Life; Loneliness; Macaca; Macaca mulatta; Measures; Mediation; Mental Depression; Methaqualone; Modeling; Monoamine Oxidase A; Morbidity - disease rate; Outcome; Parasympathetic Nervous System; Pathologic; Personality; Persons; Phenotype; Physiological; Physiology; Plasma; Population; Procedures; Psychopathology; Psychophysiology; Reporting; Research; Resources; Risk; Science; Sea; Serotonin; Sinus Arrhythmia; Standardization; Stimulus; Sympathetic Nervous System; System; Temperament; Testing; Time; United States National Institutes of Health; Variant; Work; behavior measurement; behavior test; biobehavior; darwinism; early childhood; electric impedance; experience; infancy; innovation; mortality; negative affect; nonhuman primate; novel; phenotypic biomarker; predictive marker; programs; promoter; public health relevance; respiratory; success

 DESCRIPTION (provided by applicant): Why is it that some people float through life in a sea of tranquility while others are constantly riding an emotional roller coaster? Why do some emotionally reactive babies grow up to become calm, centered adults and others remain volatile? Questions about the origins and persistence of variation in emotional life are some of the most important questions for psychiatric and developmental science. The goal of the proposed research is to investigate variation in infants in one system that is important for emotional life-the autonomic nervous system. To that end, we will quantify spontaneous variation in activity of the two branches of the autonomic nervous system (ANS)-the parasympathetic nervous system (PNS) and the sympathetic nervous system (SNS). Activity of the PNS and SNS, which work together to maintain homeostasis is highly variable between people, thought to imbue the stimulus environment with affective meaning, and related to variation in both healthy and pathological affective experience, both healthy and pathological. Variation appears to manifest at least by early childhood but what we do not know is how much variation exists in ANS functioning during infancy, whether early ANS variation relates to other behavioral or biological phenotypes, how stable variation is across development, and what predicts its stability. The proposed research will fill these knowledge gaps. We propose to record ANS activity from infants after they complete a standardized assessment of their behavioral phenotypes and biological profiles as part of the BioBehavioral Assessment program (BBA; OD010962). We will then evaluate whether variation in established behavioral phenotypes (e.g., temperament) and biological markers (e.g., plasma cortisol levels, c-reactive protein levels; serotonin and monoamine oxidase A promoter genotypes) predict ANS activity, and whether variation is stable across the first year of life. The long term goal of the proposed research is to establish rhesus monkeys as a good model for affect development across early development so that we can subsequently identify early biomarkers of and treatments for psychopathology.

 描述（由申请人提供）：为什么有些人在平静的海洋中漂浮，而另一些人则不断地乘坐情绪过山车？为什么有些情绪反应的婴儿长大后会变得平静，以人为本，而另一些则仍然不稳定？关于情感生活中变异的起源和持续性的问题是精神病学和发展科学中最重要的问题之一。这项研究的目的是调查婴儿在一个对情感生活很重要的系统--自主神经系统中的变化。为此，我们将量化自主神经系统（ANS）的两个分支-副交感神经系统（PNS）和交感神经系统（SNS）的活动的自发变化。活动的PNS和SNS，一起工作，以维持稳态是高度可变的人之间，认为充满了情感意义的刺激环境，并与健康和病理的情感体验，健康和病理的变化。变异似乎至少在幼儿期表现出来，但我们不知道的是婴儿期ANS功能存在多少变异，早期ANS变异是否与其他行为或生物表型有关，变异在整个发育过程中有多稳定，以及什么可以预测其稳定性。这项研究将填补这些知识空白。我们建议在婴儿完成对其行为表型和生物学特征的标准化评估后记录ANS活性，作为BioBehavioral评估计划（BBA; OD 010962）的一部分。然后，我们将评估既定行为表型的变化（例如，气质）和生物标记（例如，血浆皮质醇水平、C-反应蛋白水平、5-羟色胺和单胺氧化酶A启动子基因型）预测ANS活性，以及在生命的第一年中变化是否稳定。拟议研究的长期目标是将恒河猴建立为早期发展中情感发展的良好模型，以便我们随后可以确定精神病理学的早期生物标志物和治疗方法。