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Cognitive, Socioaffective, and Neural Development Following Fetal Zika Virus Infection

胎儿寨卡病毒感染后的认知、社会情感和神经发育

基本信息

批准号：
10407045
负责人：
Eliza Bliss-Moreau
金额：
$ 56.67万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-19 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10407045
关键词：
5 year old Affective Age Animal Model Animals Area Astrocytes Attention Behavioral Birth Brain Child Child Development Childhood Cognition Cognitive Control Groups Data Development Epidemic Evaluation Exposure to Face Fetal Development Fetus First Pregnancy Trimester Grant Head Health Promotion Histologic Human Human Pathology Immune response Individual Infant Infection Intervention Intravenous Kinetics Laboratories Learning Length Macaca Macaca mulatta Magnetic Resonance Imaging Maps Measures Memory Microcephaly Microglia Modeling Mothers Neuraxis Neurobiology Neurologic Neurological outcome Outcome Pathology Pathway Analysis Personal Satisfaction Procedures Process Psychopathology Risk Sampling Second Pregnancy Trimester Severities Social Behavior Social Network Standardization Stimulus Testing Time Tissues Viral Viral Load result Viremia Work ZIKA ZIKV infection Zika Virus behavior observation cognitive development cognitive task cohort cranium design effective intervention effective therapy experience fetal improved in utero indexing neurodevelopment nonhuman primate predictive modeling prospective relating to nervous system social social relationships viral RNA

项目摘要

Project Summary/Abstract At its most extreme, fetal Zika virus infection causes microcephaly – the significant shrinking of the fetal brain and skull. Accumulating evidence suggests that microcephaly is just one possible outcome of fetal Zika virus infection, however, and that babies born with normal sized heads may have significant central nervous system pathology. The long-term consequences of this pathology are unknown, leaving open the possibility of a secondary epidemic resulting from compromised cognition and socioaffective processing that will occur as babies born during the epidemic age. The proposed work takes the first step in developing an understanding of the consequences of this pathology by mapping the cognitive and socioaffective of a cohort of nonhuman primates infected with Zika virus as fetuses and a group of procedure matched, non-infected controls. We will evaluate the extent to which maternal and fetal viremia influences cognitive, socioaffective, and neurological outcomes. Because macaques develop approximately four times faster than humans, we will be able to prospectively model pathology that arises – that is, we will be able to predict what pathology human babies, infected with Zika virus during the 2015-2016 epidemic, will experience as they grow up. Developmental modeling of this sort is critical for developing effective interventions and treatments to encourage healthy development and ameliorate psychopathology.

项目总结/摘要在最极端的情况下，胎儿寨卡病毒感染会导致小头畸形--胎儿大脑的显著萎缩还有头骨越来越多的证据表明，小头畸形症只是胎儿寨卡病毒的一种可能结果。然而，感染，以及出生时头部大小正常的婴儿可能具有重要的中枢神经系统病理这种病理学的长期后果尚不清楚，留下了一种可能性，由于认知和社会情感处理受损而导致的继发性流行病，在流行病时期出生的婴儿。拟议的工作迈出了理解的第一步，通过绘制一组非人类的认知和社会情感，作为胎儿的感染寨卡病毒的灵长类动物和一组程序匹配的未感染对照。我们将评估母体和胎儿病毒血症对认知、社会情感和神经系统的影响程度结果。由于猕猴的发育速度大约是人类的四倍，我们将能够前瞻性地模拟出现的病理-也就是说，我们将能够预测人类婴儿的病理，在2015-2016年疫情期间感染寨卡病毒的人，在成长过程中都会经历这样的经历。发育这种建模对于开发有效的干预和治疗方法以鼓励健康至关重要。发展和改善精神病理学。