Enhancements to the SPF Colony to Increase Production and Efficiency in Management

增强 SPF 群体以提高产量和管理效率

• 批准号: 10405992
• 负责人: Joyce Kimberly Cohen
• 金额: $ 40.84万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-03 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10405992
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adult; Animal Model; Animals; Breeding; Custom; Ensure; Female; Funding; Genetic Variation; Goals; Grant; Growth; HIV Infections; Health Surveys; Human Resources; Individual; Location; Macaca mulatta; Modeling; Monoclonal Antibody R24; Parents; Periodicity; Population; Primates; Procedures; Process; Production; Research; Research Project Grants; Resources; Risk; Scientist; Sex Ratio; Speed; Surveys; Testing; Time; United States National Institutes of Health; Women' s Group; genetic pedigree; germ free condition; improved; male; nonhuman primate; novel; parent grant; preclinical study; prevent; programs; restraint; success; therapy development

Project Summary/ Abstract The AIDS research portfolio at Yerkes National Primate Research Center (YNPRC) has continued to expand as demonstrated by a peak growth of approximately $6.5 million dollars (30% increase) in nonhuman primate (NHP) AIDS research grant funding over the past eight years. This growth in grant funding is accompanied by a high demand for Indian-origin specific pathogen free (SPF) rhesus macaques as the animal model for this research. YNPRC has continued to maintain a colony of SPF rhesus macaques under the parent grant (U42 OD011023) to provide these animals for HIV/AIDS research. This supplement application titled “Enhancements to the SPF Colony to Increase Production and Efficiency in Management” requests support for (1) the addition of novel “introduction enclosures” to select U42 supported compounds in the SPF colony that will ultimately increase production in the breeding colony and (2) the acquisition of a mobile procedure room and new capture tunnels that improve the efficiency of annual animal examinations and SPF testing of the colony. The goals of this supplement proposal will facilitate enhancements to the management and husbandry core in the parent U42 grant. The goals of the husbandry and management core are to leverage the resources provided by the U42 to maximize production of Indian-origin rhesus monkeys and facilitate allocation of these animals for NIH-funded HIV/AIDS research. This supplemental application will contribute to these goals with the following two specific aims: (1) to build additional introduction enclosures to improve the success of the introduction of multiple breeder males to female groups, thereby improving adult sex ratios and animal production and (2) to acquire a veterinary trailer and restraint capture tunnels to improve the efficiency of annual health surveys performed on the SPF colony at the Field Station Achieving these aims will help increase production and enhance management of the Yerkes U42 supported SPF breeding colony to ensure the program is sustainable, providing the necessary animals to support the HIV/AIDS research program using Indian-origin rhesus monkeys. The availability of this critical resource to scientists performing preclinical studies using the rhesus monkey model will have a positive, significant impact on the development of treatments to prevent or cure infection from HIV in people.

项目摘要/摘要 Yerkes国家灵长类动物研究中心（YNPRC）的艾滋病研究组合继续扩展 非人类灵长类动物的峰值增长约为650万美元（增长30％） （NHP）在过去的八年中，AIDS研究赠款。赠款资金的这种增长是由 对印度 - 原发性特异性病原体（SPF）猕猴的高需求作为此动物模型 研究。 YNPRC继续在父母赠款（U42 OD011023）为艾滋病毒/艾滋病研究提供这些动物。这个名为“增强功能的补充申请 向SPF殖民地提高管理层的产量和效率”的请求支持（1）增加 在SPF殖民地中选择U42支持的化合物的小说“引言围栏” 增加繁殖菌落的产量和（2）获得移动程序室和新捕获 提高年度动物检查效率和SPF测试的隧道。 该补充提案的目标将促进对管理和畜牧核心的增强 父母U42授予。饲养和管理核心的目标是利用资源 由U42提供的目的 NIH资助的艾滋病毒/艾滋病研究的动物。此补充应用将与 以下两个具体目的：（1）建立额外的介绍围栏以改善 向女性群体引入多个育种雄性，从而改善了成人性别比和动物 生产和（2）购买兽医拖车和约束捕获隧道，以提高 在现场站的SPF殖民地进行的年度健康调查 实现这些目标将有助于增加生产并增强支持的Yerkes U42的管理 SPF育种殖民地以确保该计划可持续，提供必要的动物来支持 艾滋病毒/艾滋病研究计划使用印度 - 奥林恒河猴。此关键资源的可用性 使用恒河猴模型进行临床前研究的科学家将产生积极，重大的影响 关于预防或治愈人们感染艾滋病毒感染的治疗方法。