Maintenance of the SPF Breeding Colonies at Yerkes National Primate Research Center

耶基斯国家灵长类研究中心 SPF 繁殖群的维护

• 批准号: 10090671
• 负责人: Joyce Kimberly Cohen
• 金额: $ 145.86万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10090671
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Alleles; Animal Model; Animals; Breeding; Diagnostic tests; Disease; Ensure; Fees; Foundations; Funding; Genetic; Grant; Growth; HIV; HIV Infections; Health; Income; Infection prevention; Leadership; Life Expectancy; MHC Class I Genes; Macaca; Macaca mulatta; Maintenance; Modeling; Molecular; Primates; Process; Production; Recording of previous events; Request for Applications; Research; Research Personnel; Research Project Grants; Resource Development; Resources; Scientist; Serology; Techniques; Testing; United States; United States National Institutes of Health; Viral; animal colony; animal resource; antiretroviral therapy; base; effective therapy; genetic information; genetic pedigree; germ free condition; nonhuman primate; pre-clinical; preclinical study; prevent; programs; success; therapy development

Project Summary/Abstract The AIDS research portfolio at Yerkes National Primate Research Center (YNPRC) has continued to expand as demonstrated by a growth of approximately $12 million dollars (57% increase) in nonhuman primate (NHP) AIDS research grant funding over the past five years. This growth in grant funding is accompanied by a high demand for Indian-origin specific pathogen free (SPF) rhesus macaques as the animal model for this research. YNPRC has maintained a colony of SPF rhesus macaques (previously with U24 support) in order to provide these animals for HIV/AIDS research. This application requests continued support (now a U42 mechanism) to expand the SPF colony by maximizing production. The application includes the Overview; Husbandry and Management Core; the Viral Testing Core; and the MHC Genetic Typing Core. This grant will support a subset of the overall YNPRC SPF colony and will derive program income from animal assignment fees and per diems. YNPRC will provide institutional support to cover remaining expenses for this colony as well as the remainder of the SPF colony. Management and Husbandry: To leverage the resources provided by the U42 to maximize production of Indian-origin rhesus monkeys and facilitate allocation of these animals for NIH-funded HIV/AIDS research. Viral Testing: To provide serological and molecular viral diagnostic testing in support of the SPF colony and to maintain a colony free of diseases that impact AIDS-related research at the Yerkes NPRC. MHC Genetic Typing: To provide parentage testing, comprehensive analysis of MHC class I and class II alleles, and to develop new techniques for detailed genetic characterization to support a genetically healthy breeding colony and provide genetic information on animals essential to the animal assignment process in support of AIDS research. Achieving these aims will ensure the Yerkes NPRC SPF breeding program is sustainable, providing the necessary animals to support our HIV/AIDS research program using Indian-origin rhesus monkeys. The availability of this critical resource to scientists performing preclinical studies using the rhesus monkey model will have a positive, significant impact on the development of treatments to prevent or cure infection from HIV in people.

项目摘要/摘要 Yerkes国家灵长类动物研究中心（YNPRC）的艾滋病研究组合继续扩展 正如非人类灵长类动物（NHP）增长约1200万美元（增长57％）所证明的 艾滋病研究授予了过去五年的资金。赠款资金的增长伴随着高 对印度 - 原发性特异性病原体（SPF）猕猴作为这项研究的动物模型的需求。 YNPRC维持了SPF恒河猕猴（以前提供U24支持）的殖民地，以提供 这些动物用于艾滋病毒/艾滋病研究。此应用程序请求继续支持（现在是U42机制） 通过最大化生产来扩展SPF殖民地。该应用程序包括概述；饲养和 管理核心；病毒测试核心；和MHC遗传分型核心。该赠款将支持一个子集 YNPRC SPF殖民地的整体，将从动物分配费和每个Diems中获得计划收入。 YNPRC将提供机构支持，以支付该殖民地以及其余的剩余费用 SPF殖民地。 管理和饲养：利用U42提供的资源来最大化生产 印度 - 原来的恒河猴，并促进这些动物分配用于NIH资助的艾滋病毒/艾滋病研究。 病毒测试：提供血清学和分子病毒诊断测试以支持SPF菌落和TO 维持没有影响Yerkes NPRC与艾滋病相关研究的疾病的殖民地。 MHC遗传分类：为了提供亲父体系测试，对MHC I和II类的全面分析 等位基因，并开发新技术以详细的遗传特征来支持遗传健康 繁殖菌落并提供有关动物分配过程必不可少的动物的遗传信息 支持艾滋病研究。 实现这些目标将确保Yerkes NPRC SPF育种计划可持续，提供 使用印度 - 原生恒河猴子支持我们的艾滋病毒/艾滋病研究计划的必要动物。这 使用Rhesus Monkey模型对科学家进行此关键资源的可用性 将对预防或治愈HIV感染的治疗的发展产生积极的重大影响 在人中。