UNC Center for AIDS Research Core E Clinical Pharmacology/Analytical Chemistry

北卡罗来纳大学艾滋病研究中心核心 E 临床药理学/分析化学

• 批准号: 10404031
• 负责人: Angela D Kashuba
• 金额: $ 30.04万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-20 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10404031
• 关键词: AIDS clinical trial group; AIDS prevention; Acquired Immunodeficiency Syndrome; Adherence; Ally; Analytical Chemistry; Applications Grants; Area; Biological; Biological Assay; Blood; Cells; Chemistry; Clinical; Clinical Pharmacology; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Communities; Complex; Consultations; Country; Data; Development; Drug Exposure; Drug Industry; Environment; Epidemic; Epidemiology; Evaluation; Faculty; Feedback; Formulation; Foundations; Generations; Goals; Government; HIV; HIV Vaccine Trials Network; Hair; Health; Historically Black Colleges and Universities; Image; Imaging technology; Implant; Individual; Infrastructure; Injectable; Institution; Interest Group; International; International Maternal Pediatric Adolescent AIDS Clinical Trials; Investigation; Leadership; Liquid substance; Methodology; Methods; Modeling; Monitor; Monte Carlo Method; Mucous Membrane; NIH Grants and Contracts; Nonprofit Organizations; North Carolina; Performance; Persons; Pharmacology; Pharmacy Schools; Policies; Population; Prevention; Private Sector; Procedures; Publications; Research; Research Design; Research Personnel; Research Priority; Resources; Services; Spottings; Standardization; Strategic Planning; Surveys; Techniques; Therapeutic; Tissues; Toxic effect; Translations; United States National Institutes of Health; Universities; Work; World Health Organization; antiretroviral therapy; base; cohort; comorbidity; cost; data repository; design; drug development; global health; innovation; innovative technologies; interdisciplinary approach; meetings; member; next generation; novel; outreach; pharmacokinetics and pharmacodynamics; pharmacometrics; pre-clinical; response; simulation; small molecule; transgender women; translational approach; working group

PROJECT SUMMARY/ABSTRACT – CLINICAL PHARMACOLOGY AND ANALYTICAL CHEMISTRY (CPAC) CORE (CORE E) The overarching goal of the Clinical Pharmacology and Analytical Chemistry (CPAC) Core is to facilitate the development of safe, effective strategies for HIV prevention, treatment and cure. To achieve this goal, the CPAC Core provides pharmacology and bioanalytical expertise to advance research within and beyond the UNC CFAR through the following specific aims: (1) provide services to expedite translation of HIV research into therapeutic strategies, (2) introduce new services to respond to evolving HIV research needs, (3) interact within and beyond the UNC CFAR to enhance HIV research collaborations, (4) support scientific working groups, research interest groups, early stage investigators, and investigators new to HIV to develop the next generation of scientific leadership, (5) prioritize dissemination/outreach, strategic planning, and evaluation to maximize impact, and (6) follow standardized policies and procedures to promote harmonious intra-CFAR interaction. The CPAC Core executes these aims by proactively engaging investigators to identify and deliver services essential for HIV pharmacology research. The Core contributes to the design, management, analysis, and publication of HIV research by assisting with hypothesis framing, study design, and grant/proposal development, by facilitating multidisciplinary and translational approaches to clinical study design and conduct, and by selecting or generating optimal bioanalytical or pharmacometric methods, with subsequent provision of analyses, in both preclinical and clinical settings. New services are developed to respond to the evolving needs of the HIV research community working within priority research areas as well as tailored to individual investigator requests. Early stage investigators and investigators new to HIV research receive the highest priority for Core services. Strong institutional support from the UNC Eshelman School of Pharmacy allows the Core to take full advantage of existing infrastructure and resources, including contacts with faculty renowned for their expertise in specialized fields of pharmacology. The Core Co-Directors, Drs. Angela Kashuba and Mackenzie Cottrell, are responsible for Core management and strategic planning, in consultation with the Core’s Internal and External Advisory Boards, as well as through surveys of the CFAR membership and discussions at CFAR retreats.

项目摘要/摘要-临床药理学和分析 化学(CPAC)核心(E核心) 临床药理学和分析化学(CPAC)核心的总体目标是促进 制定安全、有效的艾滋病毒预防、治疗和治愈战略。为了实现这一目标，CPAC CORE提供药理学和生物分析专业知识，以推动北卡罗来纳大学CFAR内外的研究 通过以下具体目标：(1)提供服务，加速将艾滋病毒研究转化为治疗 战略，(2)推出新的服务，以应对不断变化的艾滋病毒研究需求，(3)内外互动 北卡罗来纳大学CFAR加强艾滋病毒研究合作，(4)支持科学工作组，研究兴趣 小组、早期调查人员和新接触艾滋病毒的调查人员开发下一代科学 领导力，(5)优先传播/外联、战略规划和评估，以最大限度地发挥影响，以及(6) 遵循标准化的政策和程序，促进CFAR内部的和谐互动。CPAC的核心 通过主动接触调查人员来识别和提供对艾滋病毒至关重要的服务来实现这些目标 药理学研究。核心有助于艾滋病毒的设计、管理、分析和出版 通过协助假设框架、研究设计和拨款/提案开发进行研究，通过促进 临床研究设计和实施的多学科和翻译方法，并通过选择或 产生最佳生物分析或药物计量学方法，并随后在这两种方法中提供分析 临床前和临床环境。开发新的服务以响应艾滋病毒研究不断变化的需求 社区在优先研究领域内工作，以及为个人调查人员的要求量身定做。早些时候 阶段调查人员和艾滋病毒研究新手获得核心服务的最高优先级。强壮 来自北卡罗来纳大学埃谢尔曼药学院的机构支持使Core能够充分利用 现有的基础设施和资源，包括与以专业知识著称的教职员工的联系 药理学领域。核心联席董事Angela Kashuba博士和Mackenzie Cottrell博士负责 关于核心管理和战略规划，与核心的内部和外部咨询协商 委员会，以及通过对CFAR成员的调查和CFAR务虚会上的讨论。