Social Stress, Epigenetics and Cardiometabolic Health Among Youth

青少年的社会压力、表观遗传学和心脏代谢健康

• 批准号: 10406242
• 负责人: Carmen R. Isasi
• 金额: $ 66.74万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-17 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10406242
• 关键词: Acculturation; Address; Adolescent; Adult; Affect; Age; Area; Behavioral; Biological; Biological Assay; Biological Process; Birth Place; Blood specimen; Buffers; Cardiovascular Diseases; Cardiovascular system; Child; Child Health; Childhood; Chronic; Chronic Disease; Chronic stress; Communities; Conflict (Psychology); Consequentialism; Country; DNA; DNA Damage; DNA Methylation; DNA biosynthesis; Data; Development; Diabetes Mellitus; Discrimination; Economics; Environment; Epigenetic Process; Ethnic group; Exposure to; Family; Fibrinogen; Genetic Transcription; Glucocorticoids; Health; High Prevalence; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Hydrocortisone; Hypertension; Inflammation; Intervention; Latino; Latino Population; Life; Life Cycle Stages; Link; Lipids; Mendelian randomization; Mental Health; Methods; Methylation; Mitochondria; Mitochondrial DNA; Molecular; Nature; Obesity; Outcome; Participant; Pathway interactions; Pattern; Physiological; Play; Policies; Poverty; Process; Research; Resource Allocation; Risk; Role; Sampling; Shapes; Signal Transduction; Skin; Social Environment; Socioeconomic Status; Stress; Stressful Event; Techniques; United States; Vulnerable Populations; Youth; cardiometabolism; cardiovascular health; cardiovascular risk factor; caregiving; cohort; epigenomics; ethnic identity; ethnic minority population; experience; food insecurity; genome wide methylation; health disparity; health disparity populations; novel; offspring; racial and ethnic; social; social culture; social stress; social stressor; socioeconomics; stress resilience; stressor

Project Summary There is extensive evidence that economic and social stressors shape the development of cardiovascular disease starting early in the life course. However, it is largely unknown how social and economic stressors affect biological processes, particularly at the cellular level and whether these processes are evident among children and adolescents. Latinos, the largest and fastest growing ethnic minority group in the United States, have a high prevalence of cardiovascular risk factors and experience higher rates of poverty and social stressors in both childhood and adulthood compared to other racial/ethnic groups. One novel method to evaluate possible mechanisms underlying the associations between stressors and cardiovascular health across the life course is DNA methylation. Recently a handful of small studies have found that stressful experiences may alter DNA methylation, thus providing a potential mechanism by which social stressors may get under the skin. We propose to examine the association between social stressors, in relation to DNA methylation, mitochondrial DNA (mtDNA) damage and cardiometabolic health, among children participating in the Hispanic Community Health Study /Study of Latinos (HCHS/SOL) Youth Study. The HCHS/SOL Youth study is a study of US Latinos, representing varied countries of origin, conducted in the US. We propose to use existing data from 1200 participants who completed the HCH/SOL Youth study and who provided blood samples. Existing blood samples will be assayed for DNA methylation age, genome-wide methylation and a mtDNA damage marker. Cardiometabolic health markers (obesity, diabetes, hypertension, inflammation and lipids) have also been assessed. Existing data also includes assessments of current family environment as well as socio-cultural factors among children. Specifically, we will examine 1) whether social and economic stressors are associated with DNA methylation age, mtDNA damage and genome-wide methylation; 2) whether DNA methylation age, genome-wide methylation and mtDNA damage is associated with cardiometabolic health among children and 3) whether socio-cultural factors (i.e, ethnic identity, parental closeness, place of birth) modify the association between social and economic stress and DNA methylation and mtDNA damage association. We will furthermore implement mendelian randomization techniques to address the cross-sectional nature of the data. Completion of this project would allow us to elucidate the impact social and economic stressors have on epigenetic and cardiometabolic markers that may help explain how stress shapes persistent population health disparities among Latino populations.

项目摘要 有广泛的证据表明经济和社会压力源于心血管的发展 疾病从生命过程开始。但是，这在很大程度上尚不清楚社会和经济压力如何 影响生物学过程，特别是在细胞水平上以及这些过程是否明显 在儿童和青少年中。拉丁美洲人，最大，增长最快的少数民族群体 美国，心血管危险因素的患病率很高，并且经历了更高的贫困率 与其他种族/族裔相比，童年和成年期的社会压力源。一本小说 评估压力源与关联的可能机制的方法 整个生命过程中的心血管健康是DNA甲基化。最近有少数小型研究 发现压力的经历可能会改变DNA甲基化，从而通过 哪些社会压力可能会在皮肤下。我们建议检查社会之间的关联 与DNA甲基化，线粒体DNA（mtDNA）损伤和心脏代谢健康有关的压力源， 在参加西班牙裔社区健康研究 /拉丁美洲人研究（HCHS /SOL）青年的儿童中 学习。 HCHS/SOL青年研究是对美国拉丁裔的研究，代表了各种各样的原籍国， 在美国进行。我们建议使用完成HCH/SOL的1200名参与者的现有数据 青年研究并提供了血液样本。现有的血液样本将用于DNA甲基化 年龄，全基因组甲基化和mtDNA损伤标记。心脏代谢健康标记（肥胖， 还评估了糖尿病，高血压，炎症和脂质）。现有数据还包括 评估当前家庭环境以及儿童的社会文化因素。具体来说， 我们将检查1）社会和经济压力是否与DNA甲基化年龄有关， mtDNA损伤和全基因组甲基化； 2）DNA甲基化年龄，全基因组的年龄是否 甲基化和mtDNA损伤与儿童的心脏代谢健康有关，3）是否是否 社会文化因素（即种族身份，父母亲密，出生地）修改 社会和经济压力和DNA甲基化和mtDNA损伤关联。我们将进一步 实施孟德尔随机技术来解决数据的横截面性质。 该项目的完成将使我们能够阐明社会和经济压力源对 表观遗传和心脏代谢标记可能有助于解释压力形状持续人群 拉丁裔人群之间的健康差异。