New York Regional Center for Diabetes Translation Research

拉丁裔糖尿病翻译研究网络--国家资源核心 拉美裔人口是美国最大的少数民族/种族群体，预计将继续 随着美国向“少数族裔占多数的国家”过渡。拉丁裔显然背负着不成比例的负担。 与非西班牙裔白人相比，糖尿病的风险更大。具有里程碑意义的拉美裔社区健康研究/研究 来自美国四个赛场中心的16,415名拉丁裔成年人中的拉丁裔(HCHS/SOL)表现出总体糖尿病 患病率为16.9%，其中41%以上未确诊，糖尿病控制水平较低。原因是什么？ 拉丁裔糖尿病的差异包括根源于结构性种族主义的社会决定因素，以及 心理社会、生活方式、生物和遗传途径。消除糖尿病差距，提高健康教育质量 在美国拉丁裔的生活中，需要创新的、文化上合适的方法来解决多层次的目标， 与社区实体合作，并应用最新的科学技术。在建议的新旧楼更新中 约克地区糖尿病翻译研究中心(NY-CDTR)，我们将以我们成功的拉丁裔为基础 糖尿病翻译研究网络--国家资源核心(“拉丁裔网络核心”)支持 专注于尖端糖尿病预防和管理的类型2到4的转化研究 强调美国拉美裔美国人社会文化适应的方法。我们将继续利用资源 和专业知识，现在包括六年的纵向跟踪(第三个，12年 正在进行中的跟踪)和来自与糖尿病相关的多个辅助研究的丰富的表型和遗传数据 在整个生命过程中进行翻译研究。此外，我们还扩展了拉丁裔网络核心的调查员 以糖尿病预防、管理和保健为目标的文化适当干预方面的专业知识 服务。在文化定制、社区参与研究、电子健康方法和使用 在现实世界的医疗保健背景下的务实干预将有助于指导最有效、可持续和 创新的拉丁语翻译研究。在这个周期中，我们寻求：1)进一步发展拉丁裔网络 核心，通过吸引新成员，建设拉美裔糖尿病翻译研究的国家能力 (特别强调早期调查人员和那些在医学上代表性不足的人)，领导 研究传播和培训活动，并召集科学兴趣小组讨论和专题 会议；2)促进专注于了解拉丁裔糖尿病健康和差异的新研究 确定可修改的干预目标，为获取具有丰富特征的六氯环己烷/溶胶提供便利 数据集和其他资源；以及3)提供关于研究概念化、设计、 对2型到4型糖尿病预防、管理和治疗的转化研究的评估和评估 拉丁裔的医疗服务。通过利用HCHS/SOL资源和我们在以下方面的专门知识 文化干预措施，以改善患有或有患糖尿病风险的拉丁裔人的健康和医疗保健， 发展中的拉丁裔网络核心将显著扩展NY-CDTR在促进 国家层面的2型至4型糖尿病转化研究。

Latino Network for Diabetes Translation Research – A National Resource Core The Latino population is the largest ethnic/racial minority group in the U.S. and is projected to continue to grow, as the U.S. transitions to a “majority-minority nation.” Latinos clearly bear a disproportionate burden of diabetes, as compared to non-Hispanic whites. The landmark Hispanic Community Health Study/Study of Latinos (HCHS/SOL) of 16,415 Latino adults from four U.S. field centers showed an overall diabetes prevalence of 16.9% with more than 41% undiagnosed, and low levels of diabetes control. The causes of Latino diabetes disparities include social determinants with their roots in structural racism, as well as psychosocial, lifestyle, biological and genetic pathways. To combat diabetes disparities and improve quality of life in US Latinos, innovative, culturally appropriate approaches are needed that address multi-level targets, partner with community entities, and apply state of science technologies. In the proposed renewal of the New York Regional Center for Diabetes Translation Research (NY-CDTR), we will build on our successful Latino Network for Diabetes Translation Research – a National Resource Core (“Latino Network Core”) supporting type 2 to 4 translational research that focuses on cutting-edge diabetes prevention and management approaches with emphasis on sociocultural adaptation for U.S. Latinos. We will continue to leverage resources and expertise of the HCHS/SOL which now includes six years of longitudinal follow-up (with a third, 12-year follow-up in process) and rich phenotypic and genetic data from multiple ancillary studies relevant to diabetes translational research across the life course. In addition, we expand the Latino Network Core’s investigator expertise in culturally appropriate interventions targeting diabetes prevention, management, and healthcare services. Expertise in cultural tailoring, community engaged research, eHealth approaches, and the use of pragmatic interventions in real-world healthcare contexts will help guide maximally effective, sustainable, and innovative translational research in Latinos. In this cycle, we seek to: 1) Further develop the Latino Network Core, building national capacity for diabetes translational research among Latinos, by engaging new members (with special emphasis on early stage investigators and those who are underrepresented in medicine), leading research dissemination and training activities, and convening scientific interest group discussions and themed meetings; 2) Foster novel research focused on understanding Latino diabetes health and disparities and identifying modifiable targets for intervention, by facilitating access to the richly characterized HCHS/SOL datasets and other resources; and 3) Provide consultation and mentorship on study conceptualization, design, assessment, and evaluation for type 2 to 4 translational research on diabetes prevention, management, and healthcare services in Latinos. By capitalizing on HCHS/SOL resources and our specialized expertise in culturally informed interventions to improve health and healthcare among Latinos with or at risk for diabetes, the evolved Latino Network Core will significantly extend the reach and impact of the NY-CDTR in promoting type 2 to 4 diabetes translational research at the national level.