New York Regional Center for Diabetes Translation Research
纽约糖尿病翻译研究区域中心
基本信息
- 批准号:10480956
- 负责人:
- 金额:$ 12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-20 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectAncillary StudyApplications GrantsAreaAwardAwarenessBehavioral SciencesBiologicalCommunitiesConsultConsultationsDataData SetDatabasesDiabetes MellitusDiabetes preventionDominicanElectronic MailEvaluationFacultyFosteringFundingGeneticHealthHealth systemHealthcareHealthcare SystemsHispanic Community Health Study/Study of LatinosHispanic PopulationsIndividualInterest GroupInterventionLatinoLatino PopulationLeadLife Cycle StagesLife StyleMedicineMentorshipMethodologyMexicanMinorityModelingNew YorkNot Hispanic or LatinoObesityOutcomeParticipantPathway interactionsPersonsPhenotypePlant RootsPopulationPrediabetes syndromePrevalenceProcessProgram DevelopmentProgram EvaluationProviderPuerto RicanQuality of lifeResearchResearch PersonnelResearch SupportResearch TrainingResourcesSamplingScienceSouth AmericanStructural RacismStudentsTechnologyTraining ActivityTranslational ResearchUrsidae FamilyVisitYouthbasebiopsychosocialcardiovascular risk factorcareer developmentcohortcombatcommunity engaged researchcommunity engagementdesigndiabetes controldiabetes managementdiabetes riskeHealthfollow-uphealth care servicehealth disparityimprovedinnovationinsightmeetingsmembermultidisciplinarynoveloffspringphenotypic datapopulation healthpsychosocialracial and ethnicracial minority populationresearch data disseminationsecondary analysissocial culturesocial determinantsspecial interest groupsuccessvirtual
项目摘要
Latino Network for Diabetes Translation Research – A National Resource Core
The Latino population is the largest ethnic/racial minority group in the U.S. and is projected to continue to
grow, as the U.S. transitions to a “majority-minority nation.” Latinos clearly bear a disproportionate burden
of diabetes, as compared to non-Hispanic whites. The landmark Hispanic Community Health Study/Study of
Latinos (HCHS/SOL) of 16,415 Latino adults from four U.S. field centers showed an overall diabetes
prevalence of 16.9% with more than 41% undiagnosed, and low levels of diabetes control. The causes of
Latino diabetes disparities include social determinants with their roots in structural racism, as well as
psychosocial, lifestyle, biological and genetic pathways. To combat diabetes disparities and improve quality of
life in US Latinos, innovative, culturally appropriate approaches are needed that address multi-level targets,
partner with community entities, and apply state of science technologies. In the proposed renewal of the New
York Regional Center for Diabetes Translation Research (NY-CDTR), we will build on our successful Latino
Network for Diabetes Translation Research – a National Resource Core (“Latino Network Core”) supporting
type 2 to 4 translational research that focuses on cutting-edge diabetes prevention and management
approaches with emphasis on sociocultural adaptation for U.S. Latinos. We will continue to leverage resources
and expertise of the HCHS/SOL which now includes six years of longitudinal follow-up (with a third, 12-year
follow-up in process) and rich phenotypic and genetic data from multiple ancillary studies relevant to diabetes
translational research across the life course. In addition, we expand the Latino Network Core’s investigator
expertise in culturally appropriate interventions targeting diabetes prevention, management, and healthcare
services. Expertise in cultural tailoring, community engaged research, eHealth approaches, and the use of
pragmatic interventions in real-world healthcare contexts will help guide maximally effective, sustainable, and
innovative translational research in Latinos. In this cycle, we seek to: 1) Further develop the Latino Network
Core, building national capacity for diabetes translational research among Latinos, by engaging new members
(with special emphasis on early stage investigators and those who are underrepresented in medicine), leading
research dissemination and training activities, and convening scientific interest group discussions and themed
meetings; 2) Foster novel research focused on understanding Latino diabetes health and disparities and
identifying modifiable targets for intervention, by facilitating access to the richly characterized HCHS/SOL
datasets and other resources; and 3) Provide consultation and mentorship on study conceptualization, design,
assessment, and evaluation for type 2 to 4 translational research on diabetes prevention, management, and
healthcare services in Latinos. By capitalizing on HCHS/SOL resources and our specialized expertise in
culturally informed interventions to improve health and healthcare among Latinos with or at risk for diabetes,
the evolved Latino Network Core will significantly extend the reach and impact of the NY-CDTR in promoting
type 2 to 4 diabetes translational research at the national level.
拉丁裔糖尿病翻译研究网络-国家资源核心
拉丁裔人口是美国最大的少数民族/种族群体,预计将继续
随着美国向“少数民族占多数的国家”过渡,拉丁裔显然承担着不成比例的负担
与非西班牙裔白人相比,具有里程碑意义的西班牙裔社区健康研究
来自美国四个现场中心的16,415名拉丁美洲成年人的拉丁美洲人(HCHS/SOL)显示出总体糖尿病
患病率为16.9%,未确诊率超过41%,糖尿病控制水平低。的原因
拉丁美洲糖尿病差异包括根源于结构性种族主义的社会决定因素,以及
心理社会、生活方式、生物和遗传途径。为了消除糖尿病差异,提高
生活在美国拉丁美洲人,创新,文化上适当的方法,需要解决多层次的目标,
与社区实体合作,并应用最新的科学技术。在拟议的新
约克地区糖尿病翻译研究中心(NY-CDTR),我们将建立在我们成功的拉丁美洲
糖尿病翻译研究网络-国家资源核心(“拉丁美洲网络核心”)支持
2至4型转化研究,重点是尖端的糖尿病预防和管理
方法,重点是美国拉丁美洲人的社会文化适应。我们将继续利用资源
和HCHS/SOL的专业知识,现在包括6年的纵向随访(第三年,12年
随访过程中)以及来自多项糖尿病相关辅助研究的丰富表型和遗传数据
贯穿整个生命过程的转化研究。此外,我们扩大了拉丁美洲网络核心的调查员
在针对糖尿病预防、管理和医疗保健的文化上适当的干预措施方面的专业知识
服务在文化定制,社区参与研究,电子健康方法和使用
在现实世界的医疗保健环境中的务实干预将有助于指导最有效,可持续,
拉丁美洲人的创新翻译研究。在这个周期中,我们寻求:1)进一步发展拉丁美洲网络
核心,通过吸引新成员,在拉丁美洲人中建立糖尿病转化研究的国家能力
(with特别强调早期研究者和那些在医学界代表性不足的人),
研究传播和培训活动,并召集科学兴趣小组讨论和主题
2)促进新的研究,重点是了解拉丁美洲糖尿病的健康和差异,
通过促进获得特征丰富的HCHS/SOL,确定可修改的干预目标
数据集和其他资源;以及3)就研究概念化,设计,
评估和评价2至4型糖尿病预防、管理和治疗转化研究,
拉丁美洲人的医疗服务。通过利用HCHS/SOL资源和我们在以下方面的专业知识,
在文化上知情的干预措施,以改善健康和医疗保健的拉丁美洲人或有风险的糖尿病,
发展中的拉丁美洲网络核心将大大扩展纽约-CDTR在促进
2型至4型糖尿病转化研究在国家一级。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Carmen R. Isasi其他文献
Genetic ancestry influences gene-environment interactions with sociocultural factors: Results from the Hispanic Community Health Study/Study of Latinos
遗传血统影响基因 - 环境与社会文化因素的相互作用:西班牙裔社区健康研究/拉丁裔研究的结果
- DOI:
10.1016/j.xhgg.2025.100451 - 发表时间:
2025-07-10 - 期刊:
- 影响因子:3.600
- 作者:
Jayati Sharma;Cristin E. McArdle;Mariaelisa Graff;Christina Cordero;Martha Daviglus;Linda C. Gallo;Carmen R. Isasi;Tanika N. Kelly;Krista M. Perreira;Gregory A. Talavera;Jianwen Cai;Kari E. North;Lindsay Fernández-Rhodes;Genevieve L. Wojcik - 通讯作者:
Genevieve L. Wojcik
Evolving Science on Cardiovascular Disease Among Hispanic/Latino Adults: emJACC/em International
关于西班牙裔/拉丁裔成年人心血管疾病的不断发展的科学:emJACC/em 国际
- DOI:
10.1016/j.jacc.2023.02.023 - 发表时间:
2023-04-18 - 期刊:
- 影响因子:22.300
- 作者:
Amber Pirzada;Jianwen Cai;Gerardo Heiss;Daniela Sotres-Alvarez;Linda C. Gallo;Marston E. Youngblood;M. Larissa Avilés-Santa;Hector M. González;Carmen R. Isasi;Robert Kaplan;John Kunz;James P. Lash;David J. Lee;Maria M. Llabre;Frank J. Penedo;Carlos J. Rodriguez;Neil Schneiderman;Tamar Sofer;Gregory A. Talavera;Bharat Thyagarajan;Martha L. Daviglus - 通讯作者:
Martha L. Daviglus
Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids
纳入 SNP 与心理社会因素相互作用的多祖先全基因组关联分析确定了血清脂质的新位点
- DOI:
10.1038/s41398-025-03418-z - 发表时间:
2025-06-20 - 期刊:
- 影响因子:6.200
- 作者:
Amy R. Bentley;Michael R. Brown;Solomon K. Musani;Karen L. Schwander;Thomas W. Winkler;Mario Sims;Tuomas O. Kilpeläinen;Hugues Aschard;Traci M. Bartz;Lawrence F. Bielak;Jin-Fang Chai;Kumaraswamy Naidu Chitrala;Nora Franceschini;Mariaelisa Graff;Xiuqing Guo;Fernando P. Hartwig;Andrea R.V.R. Horimoto;Elise Lim;Yongmei Liu;Alisa K. Manning;Ilja M. Nolte;Raymond Noordam;Melissa A. Richard;Albert V. Smith;Yun Ju Sung;Dina Vojinovic;Rujia Wang;Yujie Wang;Mary F. Feitosa;Sarah E. Harris;Leo-Pekka Lyytikäinen;Giorgio Pistis;Rainer Rauramaa;Peter J. van der Most;Erin Ware;Stefan Weiss;Wanqing Wen;Lisa R. Yanek;Dan E. Arking;Donna K. Arnett;Christie Ballantyne;Eric Boerwinkle;Yii-Der Ida Chen;Martha L. Daviglus;Lisa de las Fuentes;Paul S. de Vries;Joseph A. C. Delaney;Amanda M. Fretts;Lynette Ekunwe;Jessica D. Faul;Linda C. Gallo;Sami Heikkinen;Georg Homuth;M. Arfan Ikram;Carmen R. Isasi;Jost Bruno Jonas;Liisa Keltikangas-Järvinen;Pirjo Komulainen;Aldi T. Kraja;Jose E. Krieger;Lenore Launer;Jianjun Liu;Kurt Lohman;Annemarie I. Luik;Ani W. Manichaikul;Pedro Marques-Vidal;Yuri Milaneschi;Stanford E. Mwasongwe;Jeffrey R. O’Connell;Kenneth Rice;Stephen S. Rich;Pamela J. Schreiner;Lars Schwettmann;James M. Shikany;Xiao-ou Shu;Jennifer A. Smith;Harold Snieder;Nona Sotoodehnia;E. Shyong Tai;Kent D. Taylor;Lesley Tinker;Michael Y. Tsai;André G. Uitterlinden;Cornelia M. van Duijn;Diana van Heemst;Melanie Waldenberger;Robert B. Wallace;Hwee-Lin Wee;David R. Weir;Wen-Bin Wei;Ko Willems van Dijk;Gregory Wilson;Jie Yao;Kristin L. Young;Xiaoyu Zhang;Wei Zhao;Xiaofeng Zhu;Alan B. Zonderman;Ian J. Deary;Christian Gieger;Hans Jörgen Grabe;Timo A. Lakka;Terho Lehtimäki;Albertine J. Oldehinkel;Martin Preisig;Ya-Xing Wang;Wei Zheng;Michele K. Evans;Michael Province;James Gauderman;Vilmundur Gudnason;Catharina A. Hartman;Bernardo L. Horta;Sharon L. R. Kardia;Charles Kooperberg;Ching-Ti Liu;Dennis O. Mook-Kanamori;Brenda WJH Penninx;Alexandre C. Pereira;Patricia A. Peyser;Bruce M. Psaty;Jerome I. Rotter;Xueling Sim;Kari E. North;Dabeeru C. Rao;Laura Bierut;Clint L. Miller;Alanna C. Morrison;Charles N. Rotimi;Myriam Fornage;Ervin R. Fox - 通讯作者:
Ervin R. Fox
Profiles of Structural Violence in Hispanic/Latino Immigrant and Non-Immigrant Parents: the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Youth Study
- DOI:
10.1007/s10903-025-01707-9 - 发表时间:
2025-06-18 - 期刊:
- 影响因子:1.800
- 作者:
Kristine Molina;Kevin Tan;Jinsong Chen;Ramon Durazo-Arvizu;Linda C. Gallo;Krista M. Perreira;Lisa Sanchez-Johnsen;Donglin Zeng;Elizabeth Pulgaron;Alan Delamater;Sage Kim;Paula G. Allen-Meares;Martha L. Daviglus;Carmen R. Isasi;Rosalba Hernandez - 通讯作者:
Rosalba Hernandez
216. Plasma ATN Biomarkers and Brain Measures Among Hispanics/Latinos Across Depressive Symptom Severity: Findings From the Study of Latinos-Investigation of Neurocognitive Aging (HCHS/SOL)
216. 不同抑郁症状严重程度的西班牙裔/拉丁裔人群中的血浆急性肾小管坏死(ATN)生物标志物和脑部指标:拉丁裔神经认知老化研究(HCHS/SOL)的发现
- DOI:
10.1016/j.biopsych.2025.02.453 - 发表时间:
2025-05-01 - 期刊:
- 影响因子:9.000
- 作者:
Natasha Z. Anita;Ariana M. Stickel;Kevin A. Gonzalez;Carmen R. Isasi;Paola Filigrana;Christian Agudelo;Sonya S. Kaur;Melissa Lamar;Linda C. Gallo;Wassim Tarraf;Douglas Galasko;Hector M. Gonzalez - 通讯作者:
Hector M. Gonzalez
Carmen R. Isasi的其他文献
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{{ truncateString('Carmen R. Isasi', 18)}}的其他基金
Metabolic, behavioral and social determinants of youth-onset T2D
青年发病 T2D 的代谢、行为和社会决定因素
- 批准号:
10583215 - 财政年份:2023
- 资助金额:
$ 12万 - 项目类别:
Social Stress, Epigenetics and Cardiometabolic Health Among Youth
青少年的社会压力、表观遗传学和心脏代谢健康
- 批准号:
10569070 - 财政年份:2021
- 资助金额:
$ 12万 - 项目类别:
Social Stress, Epigenetics and Cardiometabolic Health Among Youth
青少年的社会压力、表观遗传学和心脏代谢健康
- 批准号:
10406242 - 财政年份:2021
- 资助金额:
$ 12万 - 项目类别:
New York Regional Center for Diabetes Translation Research
纽约糖尿病翻译研究区域中心
- 批准号:
10480947 - 财政年份:2016
- 资助金额:
$ 12万 - 项目类别:
New York Regional Center for Diabetes Translation Research
纽约糖尿病翻译研究区域中心
- 批准号:
10290456 - 财政年份:2016
- 资助金额:
$ 12万 - 项目类别:
New York Regional Center for Diabetes Translation Research
纽约糖尿病翻译研究区域中心
- 批准号:
10704646 - 财政年份:2016
- 资助金额:
$ 12万 - 项目类别:
New York Regional Center for Diabetes Translation Research
纽约糖尿病翻译研究区域中心
- 批准号:
10290454 - 财政年份:2016
- 资助金额:
$ 12万 - 项目类别:
New York Regional Center for Diabetes Translation Research
纽约糖尿病翻译研究区域中心
- 批准号:
10704644 - 财政年份:2016
- 资助金额:
$ 12万 - 项目类别:
The role of self-control on adolescents' diet and exercise behaviors
自我控制对青少年饮食和运动行为的作用
- 批准号:
7314056 - 财政年份:2007
- 资助金额:
$ 12万 - 项目类别:
The role of self-control on adolescents' diet and exercise behaviors
自我控制对青少年饮食和运动行为的作用
- 批准号:
7497163 - 财政年份:2007
- 资助金额:
$ 12万 - 项目类别:
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