New York Regional Center for Diabetes Translation Research

生命课程方法论核心 纽约区域中心终身课程方法核心(LCMC)的总体目标 糖尿病翻译研究是为了支持高质量的2型糖尿病预防翻译研究 以及对整个生命周期的控制。生命过程视角侧重于生物、心理、社会和行为 个人在其生命中的特定时期经历的过程，并考察了 这些暴露在塑造疾病风险方面。目前，从观测研究中有强有力的证据表明 导致糖尿病发展的过程在生命早期就开始了，并持续到整个生命周期。这 生命过程方法还可以通过确保干预措施的有效性来加强有效干预措施的转化 战略适用于目标年龄组，并针对相关的个人或环境 障碍。遵循这一思路，我们提出了一种双管齐下的方法，以确定最相关的 可修改的风险因素和最适当的干预措施，同时考虑到有针对性的生命阶段。这个 康乐及文化事务署将利用现有的跨学科专业知识和基础设施，促进终身学习课程的应用。 展望新的转化型糖尿病研究。爱因斯坦的研究人员和他们的合作者 在糖尿病研究方面积累了数十年的专业知识，并处于有利地位 为加速翻译研究做出贡献。该中心将提供概念性和工具性 支持设计和实施新的终生糖尿病转化性研究 最终目标是减轻糖尿病负担，缓解糖尿病健康差距。这个 康乐及文化事务署的具体目标是：1)建立运用生命历程方法设计新的 转化型糖尿病研究；2)促进新的转化型糖尿病研究的实施；3) 就糖尿病健康差异背后的生物因素提供咨询和指导 寿命。

Life Course Methodology Core The overall goal of the Life Course Methodology Core (LCMC) of the New York Regional Center for Diabetes Translation Research is to support high quality type 2 translational research in diabetes prevention and control across the life span. The life course perspective focuses on the biopsychosocial and behavioral processes that individuals experience during particular periods in their life, and examines the interplay between these exposures in shaping disease risk. Currently, there is strong evidence from observational studies that the processes that lead to the development of diabetes start early in life and continue throughout the lifespan. This life course approach also can enhance the translation of efficacious interventions by ensuring that intervention strategies are appropriate for the age group targeted and address associated individual or environmental barriers. Following this line of thought, we propose a two pronged approach that identifies the most relevant modifiable risk factors and the most appropriate interventions taking into account the life stage targeted. The LCMC will leverage existing multidisciplinary expertise and infrastructure to facilitate application of a life course perspective to new translational diabetes research. Einstein investigators and their collaborators have accumulated decades of expertise in diabetes research across the life span and are well positioned to contribute to the acceleration of translational research. The LCMC will provide conceptual and instrumental support regarding the design, and implementation of new translational diabetes research across the life span with the ultimate goal of decreasing the burden of diabetes and alleviating diabetes health disparities. The LCMC specific aims are: 1) To build capacity in using the life course approach to the design of new translational diabetes research; 2) To facilitate the implementation of new translational diabetes research; 3) To provide consultation and mentorship on biological factors underlying diabetes health disparities across the lifespan.