New York Regional Center for Diabetes Translation Research

纽约糖尿病翻译研究区域中心

• 批准号: 10704644
• 负责人: Carmen R. Isasi
• 金额: $ 9.69万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-20 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704644
• 关键词: Acceleration; Address; Adult; Age; Attention; Behavior; Behavior Therapy; Behavioral; Biological; Biological Factors; Biological Markers; Biological Process; Child; Consultations; Data; Development; Diabetes Mellitus; Diabetes prevention; Disparity; Elderly; Ensure; Ethnic Origin; Funding; Future; Goals; Health; Individual; Infrastructure; Institution; Intervention; Investigation; Life; Life Cycle Stages; Longevity; Low Income Population; Measures; Mediating; Mentorship; Methodology; Methods; Modeling; New York; Observational Study; Outcome; Pathway interactions; Pattern; Phase; Policies; Population; Population Heterogeneity; Positioning Attribute; Prevention; Primary Prevention; Process; Race; Research; Research Design; Research Personnel; Resources; Risk Factors; Secondary Prevention; Services; Shapes; Skin; Translational Research; Translations; United States National Institutes of Health; Work; age group; biopsychosocial; cohort; critical period; design; diabetes control; disorder risk; efficacious intervention; ethnic disparity; experience; health disparity; health equity; health inequalities; implementation facilitation; improved; instrument; member; middle age; mobile computing; modifiable risk; multidisciplinary; novel; prevent; programs; promote resilience; racial disparity; resilience factor; social factors; social health determinants; stressor; structural determinants; success; tertiary prevention; theories

Life Course Methodology Core The overall goal of the Life Course Methodology Core (LCMC) of the New York Regional Center for Diabetes Translation Research is to support high quality type 2 translational research in diabetes prevention and control across the life span. The life course perspective focuses on the biopsychosocial and behavioral processes that individuals experience during particular periods in their life, and examines the interplay between these exposures in shaping disease risk. Currently, there is strong evidence from observational studies that the processes that lead to the development of diabetes start early in life and continue throughout the lifespan. This life course approach also can enhance the translation of efficacious interventions by ensuring that intervention strategies are appropriate for the age group targeted and address associated individual or environmental barriers. Following this line of thought, we propose a two pronged approach that identifies the most relevant modifiable risk factors and the most appropriate interventions taking into account the life stage targeted. The LCMC will leverage existing multidisciplinary expertise and infrastructure to facilitate application of a life course perspective to new translational diabetes research. Einstein investigators and their collaborators have accumulated decades of expertise in diabetes research across the life span and are well positioned to contribute to the acceleration of translational research. The LCMC will provide conceptual and instrumental support regarding the design, and implementation of new translational diabetes research across the life span with the ultimate goal of decreasing the burden of diabetes and alleviating diabetes health disparities. The LCMC specific aims are: 1) To build capacity in using the life course approach to the design of new translational diabetes research; 2) To facilitate the implementation of new translational diabetes research; 3) To provide consultation and mentorship on biological factors underlying diabetes health disparities across the lifespan.

生活课程方法核心 纽约地区中心的生命课程方法核心（LCMC）的总体目标 糖尿病翻译研究是为了支持糖尿病预防糖尿病的高质量2型转化研究 并在整个寿命中控制。生活课程的观点重点是生物心理社会和行为 个人在生活中特定时期经历的过程，并检查 这些暴露在塑造疾病风险中。目前，观察性研究有大量证据表明 导致糖尿病的发展的过程始于生命的早期，并在整个生命周期内持续。这 生命课程方法还可以通过确保干预来增强有效干预的翻译 策略适合针对年龄段的人群，并解决相关的个人或环境 障碍。遵循这种思路，我们提出了一种两种规定的方法，可以识别最相关的方法 考虑到目标的生命阶段，可修改的风险因素和最适当的干预措施。这 LCMC将利用现有的多学科专业知识和基础设施来促进生活课程的应用 新的转化糖尿病研究的观点。爱因斯坦调查人员及其合作者 在整个寿命中，积累了数十年的糖尿病研究专业知识，并且可以很好地 有助于转化研究的加速。 LCMC将提供概念和工具 在整个生命周期内设计和实施新的转化糖尿病研究的支持 最终的目标是减轻糖尿病负担并减轻糖尿病的健康差异。这 LCMC特定的目的是：1）在使用生命课程方法设计新设计方面建立能力 翻译糖尿病研究； 2）促进新的转化糖尿病研究的实施； 3） 提供有关整个糖尿病的生物因素的咨询和指导 寿命。