New York Regional Center for Diabetes Translation Research

生命历程方法论核心 纽约区域中心生命历程方法核心（LCMC）的总体目标是 糖尿病转化研究是支持高质量的2型糖尿病预防转化研究 和控制整个生命周期。生命历程的观点侧重于生物心理社会和行为 个人在其生活中的特定时期所经历的过程，并检查 这些暴露在形成疾病风险。目前，观察性研究的有力证据表明， 导致糖尿病发展的过程在生命早期开始并持续整个生命周期。这 生命过程方法还可以通过确保干预措施 战略适合于目标年龄组，并针对相关个人或环境 隔栏.按照这一思路，我们提出了一个双管齐下的方法，确定最相关的 可改变的风险因素和考虑到所针对的生命阶段的最适当干预措施。的 LCMC将利用现有的多学科专业知识和基础设施，以促进生命历程的应用 新的转化糖尿病研究的前景。爱因斯坦的研究人员和他们的合作者 在整个生命周期中积累了数十年的糖尿病研究专业知识， 有助于加速转化研究。LCMC将提供概念和工具 支持在整个生命周期内设计和实施新的转化型糖尿病研究 其最终目标是减少糖尿病的负担和缓解糖尿病健康差距。的 LCMC的具体目标是：1）建立使用生命过程方法设计新产品的能力 转化型糖尿病研究; 2）促进新的转化型糖尿病研究的实施; 3） 提供有关糖尿病健康差异背后的生物学因素的咨询和指导， 寿命

Life Course Methodology Core The overall goal of the Life Course Methodology Core (LCMC) of the New York Regional Center for Diabetes Translation Research is to support high quality type 2 translational research in diabetes prevention and control across the life span. The life course perspective focuses on the biopsychosocial and behavioral processes that individuals experience during particular periods in their life, and examines the interplay between these exposures in shaping disease risk. Currently, there is strong evidence from observational studies that the processes that lead to the development of diabetes start early in life and continue throughout the lifespan. This life course approach also can enhance the translation of efficacious interventions by ensuring that intervention strategies are appropriate for the age group targeted and address associated individual or environmental barriers. Following this line of thought, we propose a two pronged approach that identifies the most relevant modifiable risk factors and the most appropriate interventions taking into account the life stage targeted. The LCMC will leverage existing multidisciplinary expertise and infrastructure to facilitate application of a life course perspective to new translational diabetes research. Einstein investigators and their collaborators have accumulated decades of expertise in diabetes research across the life span and are well positioned to contribute to the acceleration of translational research. The LCMC will provide conceptual and instrumental support regarding the design, and implementation of new translational diabetes research across the life span with the ultimate goal of decreasing the burden of diabetes and alleviating diabetes health disparities. The LCMC specific aims are: 1) To build capacity in using the life course approach to the design of new translational diabetes research; 2) To facilitate the implementation of new translational diabetes research; 3) To provide consultation and mentorship on biological factors underlying diabetes health disparities across the lifespan.