New York Regional Center for Diabetes Translation Research

拉丁裔糖尿病翻译研究网络-国家资源核心 拉丁裔人口是美国最大的少数民族/种族群体，预计将继续 随着美国向“少数民族占多数的国家”过渡，拉丁裔显然承担着不成比例的负担 与非西班牙裔白人相比，具有里程碑意义的西班牙裔社区健康研究 来自美国四个现场中心的16，415名拉丁美洲成年人的拉丁美洲人（HCHS/SOL）显示出总体糖尿病 患病率为16.9%，未确诊率超过41%，糖尿病控制水平低。的原因 拉丁美洲糖尿病差异包括根源于结构性种族主义的社会决定因素，以及 心理社会、生活方式、生物和遗传途径。为了消除糖尿病差异，提高 生活在美国拉丁美洲人，创新，文化上适当的方法，需要解决多层次的目标， 与社区实体合作，并应用最新的科学技术。在拟议的新 约克地区糖尿病翻译研究中心（NY-CDTR），我们将建立在我们成功的拉丁美洲 糖尿病翻译研究网络-国家资源核心（“拉丁美洲网络核心”）支持 2至4型转化研究，重点是尖端的糖尿病预防和管理 方法，重点是美国拉丁美洲人的社会文化适应。我们将继续利用资源 和HCHS/SOL的专业知识，现在包括6年的纵向随访（第三年，12年 随访过程中）以及来自多项糖尿病相关辅助研究的丰富表型和遗传数据 生命历程中的转化研究。此外，我们扩大了拉丁美洲网络核心的调查员 在针对糖尿病预防、管理和医疗保健的文化上适当的干预措施方面的专业知识 服务在文化定制，社区参与研究，电子健康方法和使用 在现实世界的医疗保健环境中的务实干预将有助于指导最有效，可持续， 拉丁美洲人的创新翻译研究。在这个周期中，我们寻求：1）进一步发展拉丁美洲网络 核心，通过吸引新成员，在拉丁美洲人中建立糖尿病转化研究的国家能力 (with特别强调早期研究者和那些在医学界代表性不足的人）， 研究传播和培训活动，并召集科学兴趣小组讨论和主题 2）促进新的研究，重点是了解拉丁美洲糖尿病的健康和差异， 通过促进获得特征丰富的HCHS/SOL，确定可修改的干预目标 数据集和其他资源;以及3）就研究概念化，设计， 评估和评价2至4型糖尿病预防、管理和治疗转化研究， 拉丁美洲人的医疗服务。通过利用HCHS/SOL资源和我们在以下方面的专业知识， 采取文化上知情的干预措施，改善患有糖尿病或有糖尿病风险的拉丁裔人的健康和医疗保健， 发展中的拉丁美洲网络核心将大大扩展纽约-CDTR在促进 2型至4型糖尿病转化研究在国家一级。

Latino Network for Diabetes Translation Research – A National Resource Core The Latino population is the largest ethnic/racial minority group in the U.S. and is projected to continue to grow, as the U.S. transitions to a “majority-minority nation.” Latinos clearly bear a disproportionate burden of diabetes, as compared to non-Hispanic whites. The landmark Hispanic Community Health Study/Study of Latinos (HCHS/SOL) of 16,415 Latino adults from four U.S. field centers showed an overall diabetes prevalence of 16.9% with more than 41% undiagnosed, and low levels of diabetes control. The causes of Latino diabetes disparities include social determinants with their roots in structural racism, as well as psychosocial, lifestyle, biological and genetic pathways. To combat diabetes disparities and improve quality of life in US Latinos, innovative, culturally appropriate approaches are needed that address multi-level targets, partner with community entities, and apply state of science technologies. In the proposed renewal of the New York Regional Center for Diabetes Translation Research (NY-CDTR), we will build on our successful Latino Network for Diabetes Translation Research – a National Resource Core (“Latino Network Core”) supporting type 2 to 4 translational research that focuses on cutting-edge diabetes prevention and management approaches with emphasis on sociocultural adaptation for U.S. Latinos. We will continue to leverage resources and expertise of the HCHS/SOL which now includes six years of longitudinal follow-up (with a third, 12-year follow-up in process) and rich phenotypic and genetic data from multiple ancillary studies relevant to diabetes translational research across the life course. In addition, we expand the Latino Network Core’s investigator expertise in culturally appropriate interventions targeting diabetes prevention, management, and healthcare services. Expertise in cultural tailoring, community engaged research, eHealth approaches, and the use of pragmatic interventions in real-world healthcare contexts will help guide maximally effective, sustainable, and innovative translational research in Latinos. In this cycle, we seek to: 1) Further develop the Latino Network Core, building national capacity for diabetes translational research among Latinos, by engaging new members (with special emphasis on early stage investigators and those who are underrepresented in medicine), leading research dissemination and training activities, and convening scientific interest group discussions and themed meetings; 2) Foster novel research focused on understanding Latino diabetes health and disparities and identifying modifiable targets for intervention, by facilitating access to the richly characterized HCHS/SOL datasets and other resources; and 3) Provide consultation and mentorship on study conceptualization, design, assessment, and evaluation for type 2 to 4 translational research on diabetes prevention, management, and healthcare services in Latinos. By capitalizing on HCHS/SOL resources and our specialized expertise in culturally informed interventions to improve health and healthcare among Latinos with or at risk for diabetes, the evolved Latino Network Core will significantly extend the reach and impact of the NY-CDTR in promoting type 2 to 4 diabetes translational research at the national level.