sTMS for Substance Use-disordered Veterans

针对药物使用障碍退伍军人的 sTMS

• 批准号: 10427191
• 负责人: JOHN E MCGEARY
• 金额: --
• 依托单位: PROVIDENCE VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10427191
• 关键词: Alcohol withdrawal syndrome; Alcohols; Behavior Therapy; Biological; Brain; Calibration; Clinical Trials; Cocaine; Cues; Devices; Disease; Dropout; Electricity; Feasibility Studies; Foundations; Future; Genetic; Goals; Impairment; Infrastructure; Intervention; Measures; Mental Health; Modality; Opioid; Participant; Pharmacological Treatment; Pharmacology; Pharmacotherapy; Pilot Projects; Population; Protocols documentation; Psychotherapy; Quality of life; Rehabilitation therapy; Relapse; Risk; Safety; Standardization; Substance Use Disorder; Techniques; Testing; Transcranial magnetic stimulation; Treatment Cost; Treatment outcome; United States; Veterans; Work; acceptability and feasibility; addiction; alcohol use disorder; craving; cue reactivity; design; feasibility testing; genome sciences; improved; improved outcome; neural circuit; neuroregulation; neurorestoration; neurotechnology; noninvasive brain stimulation; novel strategies; opioid use; reduced substance use; rehabilitation research; repetitive transcranial magnetic stimulation; response; stimulant dependence; substance use; substance use treatment; success

The goal of this proposal is to evaluate preliminary participant response to a pilot, controlled, feasibility study to evaluate changes in craving, substance use, and quality of life after 6 weeks of a low-risk non-invasive brain stimulation technique, called Synchronized Transcranial Magnetic Stimulation (sTMS), compared to sham, in Veterans with a substance use disorder (SUD). An important focus of this application will be evaluating the acceptability, tolerability, and safety of sTMS in this population. To our knowledge, sTMS has never been used for SUDs, and holds considerable promise as a future treatment option for these prevalent disorders. However initial work in the acceptability, tolerability, and safety of this approach must be conducted first. This project is the first step towards our long-term goal, which is to combine non-invasive brain stimulation with individualized psychotherapy or pharmacotherapy to reduce SUD problems and improve quality of life for Veterans.

本提案的目标是评估参与者对试点，受控，