UAB Cancer Prevention and Control Training Program (T32)

UAB癌症防治培训项目（T32）

• 批准号: 10427303
• 负责人: Ritu Aneja
• 金额: $ 44.4万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-13 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10427303
• 关键词: Cancer Control; Training Programs; cancer prevention

In 1988, the University of Alabama at Birmingham (UAB) Cancer Prevention and Control Training Program (CPCTP) was established under an R25 mechanism and has trained 154 pre- and post-doctoral fellows over the past 28 years. Located in the Deep South, an area marked by poverty and health disparities, the CPCTP provides a critical bridge for students from diverse and disadvantaged backgrounds who seek research careers in cancer prevention and control. Currently, 55% of CPCTP trainees are underserved minorities, and 65% are female. Consonant with NCI's mission to address the nation's behavioral, biomedical, and clinical research needs for a diverse workforce (PAR-16-152), we seek to transition our CPCTP to a T32 mechanism, so that we can continue to prepare a diverse pool of highly-trained scientists who have made a major career commitment to cancer prevention and control research (3 pre- & 3 post-doctoral fellows in years 1-2, and 4- pre & 4- post doctoral fellows in years 3-5, with a planned duration of 3-years for each appointment). Over 90% of graduates from our current cycle are actively engaged in research careers showing success. Our proposed T32 adds many novel components to the CPCTP, while retaining those that have been key to our success, e.g., our team science multidisciplinary approach and strong team mentorship from 32 faculty who are members of the Cancer Control and Population Sciences and Cancer Chemoprevention Programs of the UAB Comprehensive Cancer Center (CCC) - one of the nation's first 7 NCI-designated CCCs. Our efforts are supported by a solid financial commitment by the UABCCC and our proposed aims are to: 1) recruit, educate, train and evaluate pre- and postdoctoral fellows from diverse academic disciplines to conduct interdisciplinary research in cancer prevention and control; 2) recruit a diverse cadre of well-qualified trainees who include members of minority groups, (i.e., African-Americans, Latinos/ Hispanics, and other disadvantaged groups), and capitalize on UAB's networks and resources to promote research in health disparities within the framework of cancer prevention and control; 3)provide a specialized core didactic and tailored research curricula and rich learning opportunities in cancer prevention and control (e.g., seminars, grant preparation/mock reviews), that complement (not duplicate) other UAB training programs; 4) foster the development of independent research careers in cancer prevention and control through mentoring by senior faculty who have established track records in funded research; 5) further the development of all trainees via additional coursework, additional degrees (i.e., MSPH), and obtaining independent research fellowships or career awards (e.g., F31/32, K99, DP5); 6) educate our trainees in the Responsible Conduct of Research and in areas of professional development that will enhance their future successes in research careers at universities, private institutions, or within the federal government; and 7) emphasize interdisciplinary research training (team science) to enable trainees to gain competence in at least two research areas and enhance their future ability to collaborate with professionals in other areas.

1988年，阿拉巴马大学伯明翰分校(UAB)癌症预防和控制培训计划 (CPCTP)是根据R25机制建立的，已培训了154名博士后和博士后研究员 过去的28年里。位于南方腹地，一个以贫困和健康差距为标志的地区，CPCTP 为来自不同和弱势背景的学生寻求研究事业提供了重要的桥梁 在癌症预防和控制方面。目前，CPCTP受训人员中55%是未得到充分服务的少数族裔，65%是 女性。与NCI致力于解决国家行为、生物医学和临床研究的使命相一致 为了满足多样化劳动力的需求(PAR-16-152)，我们寻求将CPCTP过渡到T32机制，以便我们 可以继续培养一批训练有素的科学家，他们在职业生涯中做出了重大承诺 癌症预防和控制研究(1-2年级3名博士后研究员，4名博士前和4名博士后 博士研究生任期为3至5年，每次任命的计划任期为3年)。90%以上的毕业生 从我们目前的周期来看，积极从事研究事业的人取得了成功。我们建议的T32增加了 CPCTP的许多新组成部分，同时保留了那些对我们的成功至关重要的组成部分，例如我们的 团队科学、多学科方法和来自32名教职员工的强大团队指导 癌症控制与人口科学和癌症化学预防综合计划 癌症中心(CCC)-全国首批7家NCI指定的CCC之一。我们的努力得到了坚实的 UABCCC的财务承诺和我们建议的目标是：1)招聘、教育、培训和评估 来自不同学科的博士后和博士后研究员在癌症领域进行跨学科研究 预防和控制；2)招募包括少数族裔成员在内的各种合格的受训人员干部 群体(即非洲裔美国人、拉丁裔/拉美裔和其他弱势群体)，并利用UAB的 在癌症预防框架内促进健康差距研究的网络和资源 3)提供专门的核心教学和量身定做的研究课程和丰富的学习机会 在癌症预防和控制方面(例如，研讨会、赠款准备/模拟审查)，补充(而不是 复制)其他UAB培训方案；4)促进癌症独立研究事业的发展 通过资深教员的指导进行预防和控制，这些教员在Funding 研究；5)通过额外的课程、额外的学位(即MSPH)进一步发展所有受训人员， 并获得独立研究奖学金或职业奖项(例如，F31/32、K99、DP5)；6)培训我们的 负责任的研究行为和专业发展领域的受训人员 他们未来在大学、私立机构或联邦政府的研究生涯中取得的成功； 7)强调跨学科研究培训(团队科学)，使学员能够在 至少两个研究领域，并增强他们未来与其他领域的专业人员合作的能力。

项目成果

"Clinical trials are space travel": Factors of psychological response to recurrence among oncologists enrolling patients in treatment optimization trials.

• DOI: 10.1002/cam4.6710
• 发表时间: 2023-12
• 期刊: Cancer medicine
• 影响因子: 4

Health behaviors and well-being among those "living" with metastatic cancer in Alabama.

阿拉巴马州转移性癌症“生活者”的健康行为和幸福感。

• DOI: 10.1007/s00520-021-06583-1
• 发表时间: 2022
• 期刊: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
• 作者: Bail,JenniferR;Bail,SumanthV;Cagle,Jessica;Tiesi,Koriann;Caffey,Jayla;Bakitas,Marie;Demark-Wahnefried,Wendy
• 通讯作者: Demark-Wahnefried,Wendy

Pediatric May-Thurner Syndrome-Systematic review and individual patient data meta-analysis.

• DOI: 10.1111/jth.15284
• 发表时间: 2021-05
• 期刊: Journal of thrombosis and haemostasis : JTH
• 作者: Avila L;Cullinan N;White M;Gaballah M;Cahill AM;Warad D;Rodriguez V;Tarango C;Hoppmann A;Nelson S;Kuhn T;Biss T;Weiss A;Temple M;Amaral JG;Amiri N;Xavier AC;Renzi S;Brandão LR
• 通讯作者: Brandão LR

Strategies in Overcoming Homologous Recombination Proficiency and PARP Inhibitor Resistance.

克服同源重组水平和PARP抑制剂耐药性的策略。

• DOI: 10.1158/1535-7163.mct-20-0992
• 发表时间: 2021-09
• 期刊: Molecular cancer therapeutics
• 影响因子: 5.7

Immunophenotype-associated gene signature in ductal breast tumors varies by receptor subtype, but the expression of individual signature genes remains consistent.

• DOI: 10.1002/cam4.4095
• 发表时间: 2021-08
• 期刊: Cancer medicine
• 影响因子: 4
• 作者: Behring M;Ye Y;Elkholy A;Bajpai P;Agarwal S;Kim HG;Ojesina AI;Wiener HW;Manne U;Shrestha S;Vazquez AI
• 通讯作者: Vazquez AI