Research Training for Medical Geneticists at Mount Sinai School of Medicine

项目摘要 本申请旨在继续博士后培训补助金，题为“研究培训计划， 医学遗传学家”11-15年。该计划的总体目标是：提供一个指导的职业发展 医生-科学家进行基础/转化研究的经验，发展技能和经验 需要竞争联邦基金，并成为医学遗传学/基因组学的学术领袖。的 该计划的重点是基础，转化和/或临床研究使用最新的技术来调查 单基因和复杂性状的发病机制，并将这些发现转化为改进的诊断， 预防和有效的治疗。 遗传学和基因组科学系，拥有超过100名全职小学教师，担任 在西奈山医学的所有领域的遗传学和基因组学的整合重点。培训 环境建立在相当大的遗传/基因组，细胞和分子生物学，以及临床专业知识， 我们的基础科学和临床部门和研究所的教师。我们的培训计划的优势包括： 1)在多学科研究项目中获得资助和经验丰富的研究导师的特殊群体; 2)我们的ABMGG认证的医学遗传学培训计划; 3）基因组学教学课程， 翻译研究，包括硕士和博士课程，并在负责任的研究行为，和4） 共享研究设施（SRF）的基础设施，包括我们的基因组学和多尺度研究所 生物学 选择参加该培训计划的物理学家-科学家学员通常将在 医学遗传学我们的医学遗传学住院医师计划提供了一个潜在的候选人， 致力于基础/转化研究事业。高素质的医学遗传学家和医生- 来自其他住院医师培训项目的科学家申请人和代表性不足的少数民族候选人也将 被招募。受训人员将在他们所选择的导师的监督下获得2至3年的支持。 研究导师，每个学员将有一个适当的咨询委员会。以前的学员来自 该计划已成功获得学术和行业职位，并已申请/收到 私人机构和联邦基金。所有学员将专注于他们的研究项目，并参加我们的 每周工作进展会议，每周遗传学/基因组学研讨会系列，并可能采取选定的 教学课程或硕士学位。这项培训计划将满足对训练有素的遗传学家的迫切需要 世卫组织可以将遗传学/基因组学和生物技术的进步转化为更好的诊断、治疗 预防人类疾病。

Project Summary This application seeks to continue the postdoctoral training grant titled, "Research Training Program for Medical Geneticists" for years 11-15. The program's overall goal is to: provide a mentored career development experience for physician-scientists to perform basic/translational research, develop the skills and experience required to compete for federal funding, and to become academic leaders in medical genetics/genomics. The program's emphasis is on basic, translational and/or clinical research using the latest techniques to investigate the pathogenesis of monogenic and complex traits, and to translate these findings into improved diagnosis, prevention, and effective therapies. The Department of Genetics and Genomic Sciences, with >100 full-time primary faculty, serves as the focus for the integration of genetics and genomics in all areas of medicine at Mount Sinai. The training environment builds upon considerable genetic/genomic, cell and molecular biologic, and clinical expertise of faculty in our basic science and clinical Departments and Institutes. Strengths of our training program include: 1) an exceptional group of funded and experienced Research Mentors in multidisciplinary research programs; 2) our ABMGG-accredited Medical Genetics training programs; 3) didactic courses in genomics and translational research including MS and PhD programs, and in the Responsible Conduct of Research, and 4) an infrastructure of Shared Research Facilities (SRFs) including our Institute for Genomics and Multiscale Biology. Physician-scientist trainees chosen for this training program typically will have completed a residency in Medical Genetics. Our Medical Genetics residency programs provide a pipeline of potential candidates who have a commitment to a basic/ translational research career. Highly qualified medical geneticist and physician- scientist applicants from other residency training programs and underrepresented minority candidates also will be recruited. Trainees will be supported for a period of 2 to 3 years under the supervision of their chosen Research Mentor, and each trainee will have an appropriate Advisory Committee. Previous trainees from this program have successfully obtained academic and industry positions and have applied for/received private agency and federal funding. All trainees will focus on their research projects and participate in our weekly work-in progress conference, weekly Genetics/Genomics seminar series, and may take selected didactic courses or an MS degree. This training program will meet a critical need for well-trained geneticists who can translate advances in genetics/genomics and biotechnology into improved diagnosis, treatment, and prevention of human disease.