Research Training for Medical Geneticists at Mount Sinai School of Medicine

描述（由申请人提供）：本申请寻求继续06-10年度的博士后培训资助，题为“医学遗传学家研究培训计划”。该计划的总体目标是为医学博士医学遗传学家提供指导研究经验，以进行富有成效的独立基础/转化研究，并发展有效竞争联邦资金所需的技能和经验，并成为医学遗传学和基因组学的学术领导者。该计划的重点是遗传学和基因组学的基础和转化研究，包括基因组测序和分析，生物信息学和系统生物学分析方面的最新和持续进展的应用，对单基因和复杂性状的遗传学/基因组学的理解，并将这些发现转化为改进的诊断，预防和新的有效疗法。被选中参加这个项目的医学博士学员必须完成医学遗传学的住院医师实习。我们的医学遗传学住院医师项目提供了一批优秀的候选人，他们已经证明了对基础/转化研究事业的承诺。来自其他住院医师培训项目的高素质医学遗传学家申请人和未被充分代表的少数族裔候选人也将被招募。受训者将在我们的一位研究导师的密切监督下获得2至3年的支持，每个受训者将有一个适当的咨询委员会。该项目之前的学员已成功获得学术/行业职位，并已申请/获得联邦资助。该培训项目建立在西奈山医学院大量资源的基础上，包括：1)多学科研究项目的杰出资助研究导师，以及担任临床实验室导师和研究核心主任的教师；2)我们认可的所有ABMG专业的医学遗传学培训课程；3)基本转化研究方法的教学选修课程，以及负责任的研究行为；4)共享研究设施（srf）的基础设施，以及以疾病为导向和核心技术为基础的研究机构，包括我们新的基因组学和多尺度生物学研究所。所有受训者将参加每月的培训资助会议，每周的工作进展会议，每周的遗传学/基因组学系列研讨会，以及与外部咨询委员会的年度研究日。该培训计划将满足独立医学遗传学家的迫切需求，他们可以将遗传学/基因组学的进展转化为改善人类疾病的诊断和治疗。

DESCRIPTION (provided by applicant): This application seeks to continue for years 06-10 the postdoctoral training grant entitled, "Research Training Program for Medical Geneticists." The program's overall goal is to provide a mentored research experience for M.D. medical geneticists to perform productive independent basic/ translational research and to develop the skills and experience required to effectively compete for federal funding and become academic leaders in medical genetics and genomics. The program's emphasis is on basic and translational research in genetics and genomics, including the application of recent and continuing advances in genome sequencing and analysis, bioinformatics, and systems biology analyses, towards the understanding of the genetics/genomics of monogenic and complex traits, and to translate these findings into improved diagnosis, prevention, and new effective therapies. MD trainees chosen for this program will have completed a residency in Medical Genetics. Our Medical Genetics residency programs provides a pipeline of outstanding candidates who have demonstrated a commitment to a basic/ translational research career. Highly qualified medical geneticist applicants from other residency training programs and underrepresented minority candidates will also be recruited. Trainees will be supported for a period of 2 to 3 years under close supervision of one of our Research Mentor faculty, and each trainee will have an appropriate Advisory Committee. Previous trainees from this program have successfully obtained academic/ industry positions and have applied for/ received federal funding. This training program builds upon considerable resources at Mount Sinai including: 1) an exceptional group of funded Research Mentors in multidisciplinary research programs, as well as faculty who serve as Clinical Laboratory Preceptors and Research Core Directors; 2) our accredited Medical Genetics training programs in all the ABMG specialties; 3) didactic elective courses in basic translational research methodology, and responsible conduct of research, 4) an infrastructure of Shared Research Facilities (SRFs) and disease-oriented and core-technology-based research institutes, including our new Institute for Genomics and Multiscale Biology. All trainees will participate in a monthly Training Grant Conference, our weekly work-in progress conference, weekly Genetics/Genomics seminar series, and our annual Research Day with our External Advisory Committee. This training program will meet a critical need for independent medical geneticists who can translate advances in genetics/ genomics into improved diagnosis and treatment of human disease.