Ambulatory Methods for Measuring Cognitive Change

需要对认知变化进行准确和灵敏的测量，以推进 认识规范认知老化，提高对微妙现象的检测 神经退行性疾病临床前阶段的认知变化，如 阿尔茨海默氏症。针对RFA-AG-18-012，我们建议为 将提供这项研究的认知变化移动监测(M2C2) 以开放、灵活和可用的工具推动科学进步的社区 依赖于对认知变化的灵敏和准确的测量。我们将建造 这一基础设施通过实现以下目标来实现。首先，我们将建立快速 迭代试行和测试开发程序，以加速我们的能力 设计、部署、评估和优化候选移动认知测试，以满足 心理测量学、可访问性和参与度基准(目标1：迭代设计和 试行)。第二，评价量表的信度、结构效度和纵向效度 不同种族的移动认知测试程序(目标2：信度和效度) 概率样本。第三，我们将心理测量结果复制到独立的、 基于概率的全国代表性样本，创建全国代表性 规范(目标3：复制)。第四，我们将测试我们的管道和程序 通过评估将新措施纳入移动评估基础设施 由我们外部的调查人员提名的纳入的新措施 即刻研究小组(目标4：扩展)。

Accurate and sensitive measurement of cognitive change is required to advance the understanding of normative cognitive aging and improve the detection of the subtle cognitive changes during preclinical stages of neurodegenerative diseases, such as Alzheimer’s. In response to RFA-AG-18-012, we propose to develop infrastructure for the Mobile Monitoring of Cognitive Change (M2C2) that will provide the research community with open, flexible, and usable tools to enable scientific progress that depends on the sensitive and accurate measurement of cognitive change. We will build this infrastructure by accomplishing the following aims. First, we will establish rapid iterative piloting and test development procedures that accelerate our capacity to prototype, deploy, evaluate, and optimize candidate mobile cognitive tests to meet psychometric, accessibility, and engagement benchmarks (Aim 1: Iterative Design & Piloting). Second, evaluate reliability, construct validity, and longitudinal validity of mobile cognitive testing procedures (Aim 2: Reliability & Validity) in a racially diverse probability sample. Third, we replicate psychometric results in an independent, nationally representative probability based sample, and create nationally representative norms (Aim 3: Replication). And fourth, we will test our pipeline and procedures for incorporating new measures into the mobile assessment infrastructure by evaluating novel measures for inclusion that are nominated by investigators outside of our immediate research team (Aim 4: Extension).