Ambulatory Methods for Measuring Cognitive Change

需要对认知变化进行准确和敏感的测量， 了解认知老化的规范性，提高对细微 神经退行性疾病临床前阶段的认知变化，例如 老年痴呆为响应RFA-AG-18-012，我们建议开发基础设施， 移动的认知变化监测（M2 C2）将提供研究 开放，灵活和可用的工具，使科学进步， 取决于对认知变化的敏感和准确的测量。我们将建立 通过实现以下目标来实现这一基础设施。首先，我们将建立快速 迭代试验和测试开发程序，加快我们的能力， 原型设计、部署、评估和优化候选移动的认知测试，以满足 心理测量，可访问性和参与基准（目标1：迭代设计和 试点）。第二，评估信度，结构效度和纵向效度， 移动的认知测试程序（目标2：可靠性和有效性）在一个种族多样性 概率抽样第三，我们在一个独立的， 具有全国代表性的概率样本，并创建具有全国代表性的 规范（目标3：复制）。第四，我们将测试我们的管道和程序， 通过评估，将新的措施纳入移动的评估基础设施 由我们的研究者以外的研究者提名的新的纳入措施 直接研究小组（目标4：推广）。

Accurate and sensitive measurement of cognitive change is required to advance the understanding of normative cognitive aging and improve the detection of the subtle cognitive changes during preclinical stages of neurodegenerative diseases, such as Alzheimer’s. In response to RFA-AG-18-012, we propose to develop infrastructure for the Mobile Monitoring of Cognitive Change (M2C2) that will provide the research community with open, flexible, and usable tools to enable scientific progress that depends on the sensitive and accurate measurement of cognitive change. We will build this infrastructure by accomplishing the following aims. First, we will establish rapid iterative piloting and test development procedures that accelerate our capacity to prototype, deploy, evaluate, and optimize candidate mobile cognitive tests to meet psychometric, accessibility, and engagement benchmarks (Aim 1: Iterative Design & Piloting). Second, evaluate reliability, construct validity, and longitudinal validity of mobile cognitive testing procedures (Aim 2: Reliability & Validity) in a racially diverse probability sample. Third, we replicate psychometric results in an independent, nationally representative probability based sample, and create nationally representative norms (Aim 3: Replication). And fourth, we will test our pipeline and procedures for incorporating new measures into the mobile assessment infrastructure by evaluating novel measures for inclusion that are nominated by investigators outside of our immediate research team (Aim 4: Extension).