Ambulatory Methods for Measuring Cognitive Change

项目摘要 需要对认知变化进行准确和敏感的测量， 了解认知老化的规范性，提高对细微认知的检测 在神经退行性疾病的临床前阶段的变化，如阿尔茨海默氏症。在 作为对RFA-AG-18-012的回应，我们建议开发移动的监测基础设施， 认知变化（M2 C2）将为研究社区提供开放，灵活， 可用的工具，使科学进步，这取决于敏感和准确的 认知变化的测量。我们将通过实现以下目标来建立这一基础设施： 的目标。首先，我们将建立快速迭代的试验和测试开发程序 这将加快我们对候选移动的进行原型设计、部署、评估和优化的能力 认知测试，以满足心理测量，可访问性和参与基准（目标1： 迭代设计和试点）。第二，评估信度、结构效度和纵向效度。 移动的认知测试程序的有效性（目标2：可靠性和有效性）在一个种族多样的 概率抽样第三，我们在一个独立的，全国性的 具有代表性的基于概率的样本，并创建具有全国代表性的规范（目标3： 复制）。第四，我们将测试我们的管道和程序， 通过评估新的纳入措施，将新的纳入措施纳入移动的评估基础设施 由我们直接研究团队以外的研究者提名（目标4：扩展）。

Project Summary Accurate and sensitive measurement of cognitive change is required to advance the understanding of normative cognitive aging and improve the detection of the subtle cognitive changes during preclinical stages of neurodegenerative diseases, such as Alzheimer's. In response to RFA-AG-18-012, we propose to develop infrastructure for the Mobile Monitoring of Cognitive Change (M2C2) that will provide the research community with open, flexible, and usable tools to enable scientific progress that depends on the sensitive and accurate measurement of cognitive change. We will build this infrastructure by accomplishing the following aims. First, we will establish rapid iterative piloting and test development procedures that accelerate our capacity to prototype, deploy, evaluate, and optimize candidate mobile cognitive tests to meet psychometric, accessibility, and engagement benchmarks (Aim 1: Iterative Design & Piloting). Second, evaluate reliability, construct validity, and longitudinal validity of mobile cognitive testing procedures (Aim 2: Reliability & Validity) in a racially diverse probability sample. Third, we replicate psychometric results in an independent, nationally representative probability based sample, and create nationally representative norms (Aim 3: Replication). And fourth, we will test our pipeline and procedures for incorporating new measures into the mobile assessment infrastructure by evaluating novel measures for inclusion that are nominated by investigators outside of our immediate research team (Aim 4: Extension).