Ambulatory Methods for Measuring Cognitive Change

项目摘要 此核心的主要目标是广泛支持使用M2C2移动测试和相关 API和研究规划工具，并用于传播这些材料，以建立 研究人员需要长期的可持续性和持续的创新。这个核心的传播功能是 将数据、软件(包括源代码)、测试程序和相关文档与更广泛的 研究社区。该内核的扩展功能是为附加的数据建立过程和流水线 测试开发并促进研究社区采用M2C2工具，以用于新的和现有的 研究、临床试验和卫生保健环境。为了促进M2C2工具的采用，我们将开发 与流行的移动和调查数据收集软件的互操作性。在这个核心中，我们描述了流程 积极鼓励采用测试基础设施，并支持我们直属部门以外的研究人员 团队将根据以下建立的流程为纳入M2C2基础设施提供新的措施 这个项目。该核心将确保对研究数据和元数据的访问，以支持可复制和复制 在公平数据原则下进行研究，并鼓励外部研究人员向公开贡献数据 Science M2C2平台可加快测试开发、优化设计和数据分析。具体目标 这一核心是：(目标1)实施一项全面计划，以促进传播、吸收和持续 由研究界开发M2C2资源；(目标2)支持快速开发， 与研究团体一起验证和部署新的认知测量方法，并在 移动评估方法；以及(目标3)为了支持M2C2评估工具的广泛采用，我们 将提供公共API，以便将认知测试与其他移动和调查数据收集集成在一起 软件(例如，RedCap)。 这一整体项目的长期影响取决于移动评估在广泛的范围内的应用 研究设计和临床背景的范围。该核心将提供以下资源和协议 传播、支持和推广开放、灵活和可持续的研究基础设施。这个 这一核心的意义在于它将在测量方面支持更广泛的研究和临床社区 认知变化和加速发现的生物医学研究的重点是理解，并最终 在成年人的一生中改善认知和大脑健康。在各种途径上进行创新，以加强 研究人员参与的质量以及对M2C2测试的理解和进一步发展的支持 基础设施将提供开发和部署这些工具的动态周期。

Project Summary The primary objectives of this Core are the broad support for use of the M2C2 mobile tests and associated APIs and research planning tools and for the dissemination of these materials to build a community of researchers for long-term sustainability and continued innovation. The Dissemination function of this core is to share data, software (including source code), testing procedures, and relevant documentation with the broader research community. The Extension function of this core is to establish procedures and a pipeline for additional test development and promote uptake of M2C2 tools by the research community for use in new and existing studies, clinical trials, and health care settings. To promote uptake of M2C2 tools, we will develop interoperability with popular mobile and survey data collection software. In this Core, we describe processes for actively encouraging uptake of the test infrastructure and support of researchers outside of our immediate team to contribute new measures for inclusion in the M2C2 infrastructure following processes established by the Project. This Core will ensure access to study data and metadata to support reproducible and replication research under FAIR data principles and encourage external researchers to contribute data to the open science M2C2 platform to accelerate test development, optimal design, and data analytics. The specific aims of this Core are: (Aim 1) To implement a comprehensive plan to promote dissemination, uptake, and ongoing development of the M2C2 resource by the research community; (Aim 2) To support rapid development, validation and deployment of novel cognitive measures with the research community and sustain innovations in mobile assessment methodology; and (Aim 3) To support widespread uptake of M2C2 assessment tools, we will provide public APIs to allow integration of cognitive testing with other mobile and survey data collection software (e.g., REDCap). The long-term impact of this overall project relies on the uptake of mobile assessments in a broad range of research designs and clinical contexts. This Core will provide resources and protocol for dissemination, support, and extension of an open, flexible, and sustainable research infrastructure. The significance of this Core is that it will support the broader research and clinical community in the measurement of cognitive change and accelerate discovery in biomedical research focused on understanding, and ultimately improving, cognitive and brain health across the adult lifespan. Innovations in various avenues to enhance the quality of researcher engagement and support for uptake and further developments of the M2C2 test infrastructure will provide a dynamic cycle of development and deployment of these tools.