Ambulatory Methods for Measuring Cognitive Change

项目摘要 本核心的主要目标是广泛支持使用M2C2移动的测试和相关的 API和研究规划工具，并传播这些材料，以建立一个社区， 研究人员长期可持续发展和持续创新。该核心的传播功能是 与更广泛的组织共享数据、软件（包括源代码）、测试程序和相关文档 研究社区。这一核心的扩展功能是建立程序和管道， 测试M2C2工具的开发并促进研究界对M2C2工具的采用，以用于新的和现有的 研究、临床试验和卫生保健机构。为了促进M2C2工具的使用，我们将开发 与流行的移动的和调查数据收集软件的互操作性。在本核心中，我们描述了 积极鼓励采用测试基础设施和支持我们直接以外的研究人员 该团队将根据以下流程提供新的措施，以纳入M2C2基础设施： 该项目该核心将确保访问研究数据和元数据，以支持可重现性和复制性 根据FAIR数据原则进行研究，并鼓励外部研究人员向开放数据库贡献数据。 科学M2C2平台，加速测试开发、优化设计和数据分析。具体目标 （目标1）实施一项全面计划，促进传播、吸收和持续 研究界开发M2C2资源;（目标2）为支持快速开发， 与研究界一起验证和部署新的认知措施，并在以下方面保持创新： 移动的评估方法;以及（目标3）为了支持广泛采用M2C2评估工具，我们 将提供公共API，以允许将认知测试与其他移动的和调查数据收集集成 软件（例如，REDCap）。 这一整体项目的长期影响取决于广泛采用移动的评估， 研究设计和临床背景的范围。该核心将为以下方面提供资源和协议： 传播，支持和扩展开放，灵活和可持续的研究基础设施。的 该核心的重要性在于，它将支持更广泛的研究和临床社区的测量 认知变化和加速生物医学研究中的发现， 在整个成年期内改善认知和大脑健康。在各种途径上进行创新， 研究人员参与和支持M2C2测试的吸收和进一步发展的质量 基础设施将为这些工具的开发和部署提供一个动态循环。

Project Summary The primary objectives of this Core are the broad support for use of the M2C2 mobile tests and associated APIs and research planning tools and for the dissemination of these materials to build a community of researchers for long-term sustainability and continued innovation. The Dissemination function of this core is to share data, software (including source code), testing procedures, and relevant documentation with the broader research community. The Extension function of this core is to establish procedures and a pipeline for additional test development and promote uptake of M2C2 tools by the research community for use in new and existing studies, clinical trials, and health care settings. To promote uptake of M2C2 tools, we will develop interoperability with popular mobile and survey data collection software. In this Core, we describe processes for actively encouraging uptake of the test infrastructure and support of researchers outside of our immediate team to contribute new measures for inclusion in the M2C2 infrastructure following processes established by the Project. This Core will ensure access to study data and metadata to support reproducible and replication research under FAIR data principles and encourage external researchers to contribute data to the open science M2C2 platform to accelerate test development, optimal design, and data analytics. The specific aims of this Core are: (Aim 1) To implement a comprehensive plan to promote dissemination, uptake, and ongoing development of the M2C2 resource by the research community; (Aim 2) To support rapid development, validation and deployment of novel cognitive measures with the research community and sustain innovations in mobile assessment methodology; and (Aim 3) To support widespread uptake of M2C2 assessment tools, we will provide public APIs to allow integration of cognitive testing with other mobile and survey data collection software (e.g., REDCap). The long-term impact of this overall project relies on the uptake of mobile assessments in a broad range of research designs and clinical contexts. This Core will provide resources and protocol for dissemination, support, and extension of an open, flexible, and sustainable research infrastructure. The significance of this Core is that it will support the broader research and clinical community in the measurement of cognitive change and accelerate discovery in biomedical research focused on understanding, and ultimately improving, cognitive and brain health across the adult lifespan. Innovations in various avenues to enhance the quality of researcher engagement and support for uptake and further developments of the M2C2 test infrastructure will provide a dynamic cycle of development and deployment of these tools.