Ambulatory Methods for Measuring Cognitive Change

项目摘要 为了促进理解，需要对认知变化进行准确和灵敏的测量 标准认知老化和神经认知损伤，如阿尔茨海默病。 不幸的是，限制时间精度的方法障碍并引入了 混淆阻碍了认知变化研究的进展。移动评估方法 为克服这些障碍提供新的机会，减少地理、空间和 通过面对面认知测试施加的人员限制。我们相信使用手机 随时随地评估认知的技术具有巨大的变革潜力 通过改进认知变化的检测和准确监测进行生物医学研究。我们 将开发用于生态瞬时评估(EMA)的认知测试和软件 测量猝发研究，一种密集的纵向设计，涉及频繁的猝发， 自然主义环境中的重复评估。我们还将使用移动评估来 通过融入新颖的设计特征来增强传统的纵向设计(例如 基线评估)，并增加纵向评估的频率。 响应RFA-AG-18-012，我们建议开发移动监控基础设施 认知变化(M2C2)将为研究社区提供开放、灵活和 使科学进步有赖于灵敏和准确的可用工具 对认知变化的测量。我们将通过完成以下工作来建设这个基础设施 遵循目标。首先，我们将建立快速迭代试验和测试开发程序 加快我们构建、部署、评估和优化候选移动设备的能力 满足心理测量、可访问性和参与度基准的认知测试(目标1： 迭代设计和试验)。第二，评估信度、结构效度和纵向效度 移动认知测试程序(目标2：信度和效度)在不同种族人群中的有效性 概率样本。第三，我们将心理测量结果复制到一个独立的、全国性的 以代表性概率为基础的样本，并创建具有全国代表性的规范(目标3： 复制)。第四，我们将测试我们的管道和程序，以纳入新的 通过评估纳入的新措施，将措施纳入移动评估基础设施 由我们直接研究团队以外的研究人员提名(目标4：扩展)。

Project Summary Accurate and sensitive measurement of cognitive change is required to advance understanding of normative cognitive aging and neurocognitive impairments, such as Alzheimer's disease. Unfortunately, methodological barriers that constrain temporal precision and introduce confounds in impede progress in the study of cognitive change. Mobile assessment approaches afford novel opportunities to overcome these barriers by mitigating geographic, space and personnel constraints imposed by in-person cognitive testing. We believe that using mobile technology to assess cognition “anytime, anyplace” holds great potential to transform biomedical research by improving detection and accurate monitoring of cognitive change. We will develop cognitive tests and software for use in ecological momentary assessment (EMA) measurement burst studies, an intensive longitudinal design which involves bursts of frequent, repeated assessments in naturalistic environments. We will also use mobile assessments to enhance traditional longitudinal designs by incorporating novel designs features (e.g., double- baseline assessments), and by increasing the frequency of longitudinal assessments. In response to RFA-AG-18-012, we propose to develop infrastructure for the Mobile Monitoring of Cognitive Change (M2C2) that will provide the research community with open, flexible, and usable tools to enable scientific progress that depends on the sensitive and accurate measurement of cognitive change. We will build this infrastructure by accomplishing the following aims. First, we will establish rapid iterative piloting and test development procedures that accelerate our capacity to prototype, deploy, evaluate, and optimize candidate mobile cognitive tests to meet psychometric, accessibility, and engagement benchmarks (Aim 1: Iterative Design & Piloting). Second, evaluate reliability, construct validity, and longitudinal validity of mobile cognitive testing procedures (Aim 2: Reliability & Validity) in a racially diverse probability sample. Third, we replicate psychometric results in an independent, nationally representative probability based sample, and create nationally representative norms (Aim 3: Replication). And fourth, we will test our pipeline and procedures for incorporating new measures into the mobile assessment infrastructure by evaluating novel measures for inclusion that are nominated by investigators outside of our immediate research team (Aim 4: Extension).