Consortium for Viral Systems Biology (CViSB)
病毒系统生物学联盟 (CViSB)
基本信息
- 批准号:10469781
- 负责人:
- 金额:$ 59.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-07 至 2023-01-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAfricaBindingBiologicalCase Fatality RatesCessation of lifeClinicalCommunitiesComputational algorithmCountryData SetDevelopmentDiseaseDisease MarkerDisease OutbreaksEbolaEbola Hemorrhagic FeverEbola virusEpidemicFutureGeneticGoalsHealthcareHospitalsHumanImmunologicsImmunotherapeutic agentIndividualInfectionInfrastructureIntegration Host FactorsInvestigationLassa FeverLassa virusLeadMeasurementMedicineMissionMolecularOutcomeOutcomes ResearchPatient-Focused OutcomesPatientsPhysiologicalPlayResearchResearch InfrastructureResistanceRoleSeveritiesStatistical ModelsSurvivorsSymptomsSystemSystems BiologyTechnologyVaccinesViralViral Hemorrhagic FeversVirusWorkcohortdata accessdata toolsfightinghuman diseasehuman pathogeninnovationinsightlarge scale datamembermicrobialneutralizing antibodynovelpathogenpersonalized medicinepredictive markerpredictive modelingprogramsresponsetreatment strategy
项目摘要
Project Summary/Abstract
The Ebola epidemic that ravaged West Africa from 2013 to 2016 is by far the largest outbreak ever recorded.
Weak healthcare infrastructure, community resistance, and a slow uncoordinated response, allowed the
epidemic to spin out of control. The region, however, is no stranger to dealing with viral hemorrhagic fevers.
Lassa fever is caused by infection with Lassa virus and is hyper-endemic in West Africa. Lassa fever is similar
to Ebola in that infection with Lassa virus can lead to a severe hemorrhagic fever. Infections with both Lassa
virus and Ebola virus can lead to deaths in more than 70% of hospitalized patients.
It is estimated that tens of thousands of people die from Lassa fever each year. These numbers are likely
underestimates, as the healthcare infrastructure in the affected countries is extremely weak, surveillance
almost non-existent, and most patients never present in the hospital. Despite the high case fatality rates of
hospitalized Ebola and Lassa fever patients, however, some people appear to be able to quickly fight the
viruses, whereas others die quickly from infection. Yet, what distinguishes fatal from non-fatal disease and the
development of symptomatic versus asymptomatic infection, remain largely unknown and severely
understudied. The goal of the Consortium for Viral Systems Biology is to uncover the virus and human factors
that determine how infected individuals are able to better fight the viruses. We will achieve this goal by
investigating the following three broad aims:
Aim 1. Define virus and host factors responsible for survival and non-survival in Ebola and Lassa fever
patients.
Aim 2. Identify factors that play roles in the development of severe long-term symptoms in survivors.
Aim 3. Define factors that determine whether human individuals develop symptomatic or asymptomatic
disease.
We will accomplish these aims by applying several ‘omics’ technologies, physiological measurements, and
high-throughput experimental approaches to unique patient and survivor cohorts of Lassa fever and Ebola.
We will develop novel predictive statistical models for identifying critical disease correlates and analyze
large-scale data sets to pinpoint causal host-pathogen interactions. By elucidation the molecular networks
that play critical roles in patient outcomes, this research will allow us to identify new targets for medicines and
vaccines and inform personalized treatment strategies. Our study will also provide novel research frameworks
and computational algorithms applicable to a wide range of other human pathogens.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kristian Graugaard Andersen其他文献
Kristian Graugaard Andersen的其他文献
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{{ truncateString('Kristian Graugaard Andersen', 18)}}的其他基金
West African Emerging Infectious Disease Research Center (WA-EIDRC)
西非新发传染病研究中心 (WA-EIDRC)
- 批准号:
10653441 - 财政年份:2022
- 资助金额:
$ 59.71万 - 项目类别:
Consortium for Viral Systems Biology Administrative Core
病毒系统生物学联盟行政核心
- 批准号:
10469782 - 财政年份:2021
- 资助金额:
$ 59.71万 - 项目类别:
West African Emerging Infectious Disease Research Center (WA-EIDRC)
西非新发传染病研究中心 (WA-EIDRC)
- 批准号:
10440593 - 财政年份:2021
- 资助金额:
$ 59.71万 - 项目类别:
West African Emerging Infectious Disease Research Center (WA-EIDRC)
西非新发传染病研究中心 (WA-EIDRC)
- 批准号:
10631738 - 财政年份:2020
- 资助金额:
$ 59.71万 - 项目类别:
West African Emerging Infectious Disease Research Center (WA-EIDRC)
西非新发传染病研究中心 (WA-EIDRC)
- 批准号:
10910587 - 财政年份:2020
- 资助金额:
$ 59.71万 - 项目类别:
West African Emerging Infectious Disease Research Center (WA-EIDRC)
西非新发传染病研究中心 (WA-EIDRC)
- 批准号:
10394323 - 财政年份:2020
- 资助金额:
$ 59.71万 - 项目类别:
West African Emerging Infectious Disease Research Center (WA-EIDRC)
西非新发传染病研究中心 (WA-EIDRC)
- 批准号:
10842168 - 财政年份:2020
- 资助金额:
$ 59.71万 - 项目类别:
West African Emerging Infectious Disease Research Center (WA-EIDRC)
西非新发传染病研究中心 (WA-EIDRC)
- 批准号:
10616665 - 财政年份:2020
- 资助金额:
$ 59.71万 - 项目类别:
Consortium for Viral Systems Biology (CViSB)
病毒系统生物学联盟 (CViSB)
- 批准号:
10248803 - 财政年份:2018
- 资助金额:
$ 59.71万 - 项目类别:
Consortium for Viral Systems Biology Administrative Core
病毒系统生物学联盟行政核心
- 批准号:
10579082 - 财政年份:2018
- 资助金额:
$ 59.71万 - 项目类别:
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