West African Emerging Infectious Disease Research Center (WA-EIDRC)

先前的研究表明，在大流行之前，塞拉利昂人更频繁地 比美国人暴露在具有与严重急性呼吸道疾病交叉反应的表位的冠状病毒中 呼吸综合征冠状病毒-2(SARS-CoV-2)、SARS-CoV和中东呼吸 冠状病毒综合征(MERS-CoV)。先前接触过可引起交叉保护的冠状病毒 免疫可能有助于塞拉利昂新冠肺炎病例和死亡人数的大幅下降 莱昂纳多与美国相比。本补充剂将(1)定义体液免疫 塞拉利昂人可能通过以下途径预防感染SARS-CoV-2的反应 大流行前单抗的分离和鉴定，(2)建立诊断 新型冠状病毒试验和(3)确定交叉中和的保护反应 非人灵长类新冠肺炎模型中的单抗。

Prior studies have shown that prior to the pandemic, Sierra Leoneans had more frequent exposures than Americans to coronaviruses with epitopes that cross-react with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), SARS-CoV, and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). Prior exposure to coronaviruses that induce cross-protective immunity may contribute to the greatly reduced incidence of COVID-19 cases and deaths in Sierra Leone compared to the United States. This supplement will (1) define the humoral immune response of Sierra Leoneans that may protect against infection with SARS-CoV-2 through isolation and characterization of pre-pandemic monoclonal antibodies, (2) develop diagnostic tests for novel coronaviruses and (3) determine the protective responses of cross neutralizing monoclonal antibodies in a nonhuman primate COVID-19 model.