West African Emerging Infectious Disease Research Center (WA-EIDRC)

西非新发传染病研究中心 (WA-EIDRC)

• 批准号: 10631738
• 负责人: Kristian Graugaard Andersen
• 金额: $ 35.86万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-21 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10631738
• 关键词: Address; African; Award; COVID-19; COVID-19 outbreak; COVID-19 surveillance; Cause of Death; Clinical; Clustered Regularly Interspaced Short Palindromic Repeats; Communicable Diseases; Country; Data; Diagnostic; Diagnostic tests; Disease; Disease Outbreaks; Ebola; Emerging Communicable Diseases; Equipment; Evaluation; Fever; Funding; Future; Government; Hospitals; Infectious Diseases Research; Infrastructure; Lassa Fever; Malaria; Microfluidics; Nucleic Acids; Pathogenicity; Patients; Pharmacy facility; Public Health; Reaction; Reagent; SARS-CoV-2 variant; Sierra Leone; Site; Specimen; System; Testing; Training; Validation; Variant; base; combinatorial; data integration; data visualization; national surveillance; pathogen; respiratory; respiratory virus; response; scale up

Project Summary/Abstract: Despite bearing a high burden of infectious diseases, Sierra Leone lacks a suitable system for surveillance and outbreak response to emerging and existing pathogens. Through additional support and funding, WARN-ID will be able to not only implement a high-throughput, multi- analyte diagnostic testing platform as part of a comprehensive national surveillance system, but also build local capacity for continued testing during outbreaks of SARS-CoV-2, its variants, and other diseases like Lassa fever, Ebola, and malaria, which is the leading cause of death and illness in Sierra Leone. The data that is generated from mCARMEN will be used to obtain clinical validation and regulatory approval from the Pharmacy Board of Sierra Leone, as well as inform future scale-up and integration into data visualization platforms beyond the scope of this award. Further, developing the appropriate infrastructure to respond to COVID-19 and other pathogenic threats will impact the country’s future ability to identify and respond to potential outbreaks, by helping to lay the groundwork for a robust, sustainable public health infrastructure able to detect emerging and reemerging pathogens and their variants.

项目概要/摘要： 尽管塞拉利昂承受着传染病的沉重负担，但缺乏适当的系统， 对新出现和现有病原体的监测和疫情应对。通过额外 支持和资金，WARN-ID将不仅能够实现高通量，多 分析物诊断检测平台作为国家综合监测系统的一部分，但 并建立地方能力，以便在SARS-CoV-2及其变种爆发期间继续进行检测， 以及拉沙热、埃博拉和疟疾等其他疾病，疟疾是导致死亡的主要原因 疾病在塞拉利昂。mCARMEN生成的数据将用于获取 临床验证和塞拉利昂药剂委员会的监管批准，以及 通知未来的扩展和集成到数据可视化平台超出了这个范围， 奖此外，发展适当的基础设施以应对COVID-19和其他 病原体威胁将影响该国未来识别和应对潜在威胁的能力。 疫情，帮助奠定坚实的基础，可持续的公共卫生 能够检测新出现和重新出现的病原体及其变种的基础设施。