West African Emerging Infectious Disease Research Center (WA-EIDRC)

项目摘要/摘要： 尽管塞拉利昂承受着沉重的传染病负担，但缺乏适用于 对新出现的和现有的病原体进行监测和暴发应对。通过其他 支持和资助，WARN-ID将不仅能够实现高通量、多 分析诊断检测平台作为全面国家监测系统的一部分，但 还建设在SARS-CoV-2及其变种爆发期间继续检测的当地能力， 以及其他疾病，如拉沙热、埃博拉和疟疾，疟疾是导致死亡的主要原因 以及塞拉利昂的疾病。从mCARMEN生成的数据将用于获取 临床验证和塞拉利昂药房委员会的监管批准，以及 告知未来扩展和集成到数据可视化平台的情况超出此范围 获奖。此外，发展适当的基础设施以应对新冠肺炎和其他 病原性威胁将影响该国未来识别和应对潜在威胁的能力 疫情，通过帮助为健全、可持续的公共卫生奠定基础 能够检测新出现和再次出现的病原体及其变种的基础设施。

Project Summary/Abstract: Despite bearing a high burden of infectious diseases, Sierra Leone lacks a suitable system for surveillance and outbreak response to emerging and existing pathogens. Through additional support and funding, WARN-ID will be able to not only implement a high-throughput, multi- analyte diagnostic testing platform as part of a comprehensive national surveillance system, but also build local capacity for continued testing during outbreaks of SARS-CoV-2, its variants, and other diseases like Lassa fever, Ebola, and malaria, which is the leading cause of death and illness in Sierra Leone. The data that is generated from mCARMEN will be used to obtain clinical validation and regulatory approval from the Pharmacy Board of Sierra Leone, as well as inform future scale-up and integration into data visualization platforms beyond the scope of this award. Further, developing the appropriate infrastructure to respond to COVID-19 and other pathogenic threats will impact the country’s future ability to identify and respond to potential outbreaks, by helping to lay the groundwork for a robust, sustainable public health infrastructure able to detect emerging and reemerging pathogens and their variants.