West African Emerging Infectious Disease Research Center (WA-EIDRC)

西非新发传染病研究中心 (WA-EIDRC)

• 批准号: 10631738
• 负责人: Kristian Graugaard Andersen
• 金额: $ 35.86万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-21 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10631738
• 关键词: Address; African; Award; COVID-19; COVID-19 outbreak; COVID-19 surveillance; Cause of Death; Clinical; Clustered Regularly Interspaced Short Palindromic Repeats; Communicable Diseases; Country; Data; Diagnostic; Diagnostic tests; Disease; Disease Outbreaks; Ebola; Emerging Communicable Diseases; Equipment; Evaluation; Fever; Funding; Future; Government; Hospitals; Infectious Diseases Research; Infrastructure; Lassa Fever; Malaria; Microfluidics; Nucleic Acids; Pathogenicity; Patients; Pharmacy facility; Public Health; Reaction; Reagent; SARS-CoV-2 variant; Sierra Leone; Site; Specimen; System; Testing; Training; Validation; Variant; base; combinatorial; data integration; data visualization; national surveillance; pathogen; respiratory; respiratory virus; response; scale up

Project Summary/Abstract: Despite bearing a high burden of infectious diseases, Sierra Leone lacks a suitable system for surveillance and outbreak response to emerging and existing pathogens. Through additional support and funding, WARN-ID will be able to not only implement a high-throughput, multi- analyte diagnostic testing platform as part of a comprehensive national surveillance system, but also build local capacity for continued testing during outbreaks of SARS-CoV-2, its variants, and other diseases like Lassa fever, Ebola, and malaria, which is the leading cause of death and illness in Sierra Leone. The data that is generated from mCARMEN will be used to obtain clinical validation and regulatory approval from the Pharmacy Board of Sierra Leone, as well as inform future scale-up and integration into data visualization platforms beyond the scope of this award. Further, developing the appropriate infrastructure to respond to COVID-19 and other pathogenic threats will impact the country’s future ability to identify and respond to potential outbreaks, by helping to lay the groundwork for a robust, sustainable public health infrastructure able to detect emerging and reemerging pathogens and their variants.

项目摘要/摘要： 尽管塞拉利昂承受着沉重的传染病负担，但缺乏适当的系统 对新出现和现有病原体的监测和疫情应对。通过额外的 的支持和资助，WARN-ID将不仅能够实现高通量、多 分析物诊断测试平台作为国家综合监测系统的一部分，但是 还建设当地在 SARS-CoV-2 及其变种爆发期间继续进行检测的能力， 以及拉沙热、埃博拉和疟疾等其他疾病，这些疾病是导致死亡的主要原因 和塞拉利昂的疾病。 mCARMEN 生成的数据将用于获取 塞拉利昂药房委员会的临床验证和监管批准，以及 为未来的扩展和集成到超出本范围的数据可视化平台提供信息 奖。此外，开发适当的基础设施来应对 COVID-19 和其他 病原体威胁将影响该国未来识别和应对潜在威胁的能力 疫情爆发，帮助为强大、可持续的公共卫生奠定基础 能够检测新出现和重新出现的病原体及其变种的基础设施。