Glycan Structure Archive (GSA) prototype in support of GlyGen's data integration - Yr 5 Admin Supp

摘要 近年来，葡聚糖在生物医学研究中的重大影响，特别是在以下方面 免疫学，在生物功能中的作用，对疾病的影响，等等。近年来的技术进步 使研究人员能够更准确、更有效地进行糖组和糖蛋白组学分析， 导致文献中的数据量快速增长，并迫切需要强大的基于证据的数据 档案中的葡聚糖记录维护。这一需求至少可以由允许作者的存储库部分满足 提交和更新数据，同时数据库开发人员提供无需任何编辑的数据存档机制。 我们建议开发一个原型多糖档案(一个初级数据库)来存储注册的多糖结构 并允许用户存放新的多糖，这些多糖将与现有资源共享。预计这一努力 将导致国际管理的葡聚糖档案合作的发展，在概念上与 协调和维护国际核苷酸序列数据库合作(INSDC) 像GenBank，DDBJ，ENA这样的核苷酸数据库。多糖档案原型将由GlyGen开发 在子域名gsa.lygen.org下。它将存放来自现有公共数据库的所有糖类，如 GlyTouCan、PubChem、Chebi、KEGG葡聚糖等。稳健的质量控制程序将提高 提交的记录和所有的葡聚糖记录将与一个唯一ID相关联，该ID将被交叉引用到 其他数据库。新的基于信息学的结构验证将标记包含意外的提交 功能，允许在并入档案或二级数据库之前或之后进行额外评估。 我们预计，所提出的机制将对研究人员、数据管理员、生物信息学 数据库，还提供了特定多糖发表时间的历史记录。

ABSTRACT Recent years have highlighted the significant impact of glycans in biomedical research especially in aspects of immunology, role in biological functions, impact in diseases, and more. Technical advancements in recent years have allowed researchers to perform glycomics and glycoproteomics analysis more accurately and efficiently, resulting in rapid growth of the volume of data in the literature and a great need for robust evidence-based archival glycan record maintenance. This need can be at least partially met by a repository that allows authors to submit and update data while database developers provide mechanisms for data archiving without any editing. We propose to develop a prototype glycan archive (a primary database) to store registered glycan structures and allow users to deposit new glycans which will be shared with existing resources. It is expected that this effort will lead to the development of an internationally managed glycan archive collaboration, parallel in concept to the International Nucleotide Sequence Database Collaboration (INSDC) that harmonizes and maintains databases like GenBank, DDBJ, ENA for nucleotides. The glycan archive prototype will be developed by GlyGen under subdomain gsa.glygen.org. and it will house all glycans sourced from existing public databases like GlyTouCan, PubChem, ChEBI, KEGG glycan, and others. Robust QC procedures will enhance the value of the submitted records and all glycan records will be associated with an unique ID that will be cross-referenced to other databases. Novel informatic-based structural validation will flag submissions that contain unexpected features, allowing additional evaluation before or after incorporation into the archive or secondary databases. We anticipate that the proposed mechanism will be highly valuable for researchers, data curators, bioinformatics databases, and also provide a historical record of when a particular glycan was published.