A Biomedical Mass Spectrometry Resource: Ongoing Driving Biomedical Projects

项目摘要 华盛顿大学NIGMS生物医学资源寻求继续其成功的合作工作 生物医学研究人员致力于了解疾病和维护人类健康。此资源 支持大量需要结构蛋白质组学和复杂脂类组学的科学家 质谱学工具，其中许多是在过去15年中在本资源开发的。这个 资源中心敬业的科学家拥有一个多世纪的综合经验，并继续 与研究重要生物医学问题的调查人员合作，包括埃博拉等病毒病原体， 登革热、寨卡和马尔堡等细菌病原体，如结核病和利什曼病的病原体， 引起疟疾、阿尔茨海默氏症和帕金森氏症、糖尿病、代谢综合征、尿路疾病的疟原虫 呼吸道感染和癌症。资源工作人员调查员，受国家和国际合作者的激励 在学术、工业和政府实验室，为细胞钙的研究提供支持 调节、脂代谢、抗体-抗原结合等许多结构和功能上的问题 生物学。此外，该资源的敬业科学家将支持成功的传播、培训、 以及与科学界和更广泛的社区的联系。这笔赠款将允许他们继续申请 当这些问题过渡到其他支持来源时，质谱学就会允许他们尊重 对其庞大而多样的合作者群体的承诺。

Project Summary The Washington University NIGMS Biomedical Resource seeks to continue its successful collaborative work with biomedical researchers engaged in understanding disease and maintaining human health. This Resource supports a wide array of scientists requiring structural proteomics and complex lipidomics by expertly using mass spectrometry tools, many of which were developed at this Resource over the last 15 years. The dedicated scientists at the Resource have more than a century of combined experience and continue to collaborate with investigators working on important biomedical problems including viral pathogens like Ebola, Dengue, Zika, and Marburg, bacterial pathogens such as the causative agents of tuberculosis and leishmania, plasmodia that cause malaria, Alzheimer's and Parkinson's diseases, diabetes, metabolic syndrome, urinary tract infections, and cancer. Resource staff investigators, motivated by national and international collaborators in academic, industrial, and governmental laboratories, provide support for the study of cellular calcium regulation, lipid metabolism, antibody-antigen binding, and many other problems in structural and functional biology. In addition, the dedicated scientists at this Resource will support successful dissemination, training, and outreach to the scientific and broader communities. This grant will allow them to continue the application of mass spectrometry to these problems as they transition to other sources of support that allow them to honor commitments to their large and diverse group of collaborators.