A Biomedical Mass Spectrometry Resource: Ongoing Driving Biomedical Projects

生物医学质谱资源：持续推动生物医学项目

• 批准号: 10441142
• 负责人: MICHAEL L GROSS
• 金额: $ 65.99万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10441142
• 关键词: Affinity; Alzheimer' s Disease; Amplifiers; Amyloid beta-Protein; Antibodies; Area; Automobile Driving; Back; Binding; Binding Proteins; Biochemistry; Biological; Biology; Biomedical Research; Calcium; Cardiolipins; Ceramides; Chemistry; Collaborations; Communities; Complex; Computer Interface; Cryoelectron Microscopy; Dengue; Dengue Fever; Development; Diabetes Mellitus; Disease; Ebola; Education and Outreach; Epitopes; Fourier transform ion cyclotron resonance; Funding; Future; Goals; Government; Grant; Guidelines; Health; Human; Industrialization; International; Investigation; Investments; Ions; Isotopes; Laboratories; Lasers; Leadership; Leishmania; Light; Lipids; Location; Maintenance; Malaria; Malignant Neoplasms; Maps; Marburgvirus; Mass Spectrum Analysis; Medicine; Membrane Proteins; Metabolic; Metabolic syndrome; Metabolism; Metals; National Institute of General Medical Sciences; Parkinson Disease; Pathogenesis; Pathogenicity; Phospholipids; Physiologic pulse; Plasmodium; Positioning Attribute; Property; Protein Footprinting; Proteins; Proteomics; Recording of previous events; Regulation; Research; Research Personnel; Research Support; Resources; Role; Scientist; Services; Source; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingolipids; Structure; Triglycerides; Tuberculosis; Universities; Urinary tract infection; Virus Diseases; Washington; Work; ZIKA; acylcarnitine; antigen binding; biomedical resource; experience; human disease; innovation; instrument; instrumentation; lipid metabolism; lipidomics; mass spectrometer; medical schools; metabolomics; microorganism; novel strategies; nutrition; pathogenic bacteria; pathogenic virus; phosphoneuroprotein 14; preservation; programs; protein aggregation; protein complex; protein folding; proteogenomics; skills; tandem mass spectrometry; tau Proteins; technology research and development; tool; user-friendly

Project Summary The Washington University NIGMS Biomedical Resource seeks to continue its successful collaborative work with biomedical researchers engaged in understanding disease and maintaining human health. This Resource supports a wide array of scientists requiring structural proteomics and complex lipidomics by expertly using mass spectrometry tools, many of which were developed at this Resource over the last 15 years. The dedicated scientists at the Resource have more than a century of combined experience and continue to collaborate with investigators working on important biomedical problems including viral pathogens like Ebola, Dengue, Zika, and Marburg, bacterial pathogens such as the causative agents of tuberculosis and leishmania, plasmodia that cause malaria, Alzheimer's and Parkinson's diseases, diabetes, metabolic syndrome, urinary tract infections, and cancer. Resource staff investigators, motivated by national and international collaborators in academic, industrial, and governmental laboratories, provide support for the study of cellular calcium regulation, lipid metabolism, antibody-antigen binding, and many other problems in structural and functional biology. In addition, the dedicated scientists at this Resource will support successful dissemination, training, and outreach to the scientific and broader communities. This grant will allow them to continue the application of mass spectrometry to these problems as they transition to other sources of support that allow them to honor commitments to their large and diverse group of collaborators.

项目总结

项目成果

Development of a High-Throughput Mass Spectrometry-Based SARS-CoV-2 Immunoassay.

• DOI: 10.1021/acs.analchem.3c02421
• 发表时间: 2023-12
• 期刊: Analytical chemistry
• 影响因子: 7.4
• 作者: Jie Sun;Jong Hee Song;Mary K Danielson;Nathan D Colley;Alia Thomas;David Hambly;J. C. Barnes;Michael L. Gross