HIGH ENERGY COLLISIONAL ACTIVATION

高能碰撞激活

基本信息

  • 批准号:
    8361422
  • 负责人:
  • 金额:
    $ 0.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-01-01 至 2011-12-31
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In many cases, the need to do multiple stages of MS/MS is removed by the use of high-energy CAD. With low energy activation methods now in use, one or more additional stages of MS/MS may be required because the low ion internal energy results in the sampling of one fragmentation pathway that is non informative. The laboratory frame energies of multiply charged protein ions are calculated to be the order of 10 KeV or more for our 12-T Bruker FTMS instrument. The broad distribution of internal energies that are produced by high-energy CAD result in the sampling of multiple fragmentation pathways and an information rich product ion spectrum. Except in cases such as the quantitation of a targeted molecule, the use of multiple stages of MS/MS to extract information is costly in terms of time and sample. Recent advances in trap design have incorporated the ideas of compensation to improve the detection peformance. All of these efforts seek to remove the detrimental effects of the trapping electric field on detection performance by reshaping the trapping electric field. One of these detrimental effects is the reduction of detection performance for ions that are distributed at high radius that would result from high-energy CAD. Advances in compensation provide a means to remove this limitation that impedes the use of high-energy CAD in the FTMS experiment.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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MICHAEL L GROSS其他文献

MICHAEL L GROSS的其他文献

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{{ truncateString('MICHAEL L GROSS', 18)}}的其他基金

A Biomedical Mass Spectrometry Resource: Ongoing Driving Biomedical Projects
生物医学质谱资源:持续推动生物医学项目
  • 批准号:
    10441142
  • 财政年份:
    2020
  • 资助金额:
    $ 0.63万
  • 项目类别:
New chemical probes enable Mass Spectrometry-based footprinting of human protein structure in lipid membranes and cells
新的化学探针能够基于质谱分析脂膜和细胞中的人类蛋白质结构
  • 批准号:
    10350642
  • 财政年份:
    2019
  • 资助金额:
    $ 0.63万
  • 项目类别:
NEW CHEMICAL PROBES ENABLE MASS SPECTROMETRY-BASED FOOTPRINTING OF HUMAN PROTEIN STRUCTURE IN LIPID
新的化学探针实现了基于质谱的脂质中人类蛋白质结构的足迹
  • 批准号:
    10390166
  • 财政年份:
    2019
  • 资助金额:
    $ 0.63万
  • 项目类别:
NEW CHEMICAL PROBES ENABLE MASS SPECTROMETRY-BASED FOOTPRINTING OF HUMAN PROTEIN STRUCTURE IN LIPID MEMBRANES AND CELLS
新的化学探针能够对脂质膜和细胞中的人体蛋白质结构进行基于质谱的足迹分析
  • 批准号:
    10587527
  • 财政年份:
    2019
  • 资助金额:
    $ 0.63万
  • 项目类别:
A MASS SPECTROMETER FOR PROTEIN FOOTPRINTING
用于蛋白质足迹分析的质谱仪
  • 批准号:
    8637341
  • 财政年份:
    2014
  • 资助金额:
    $ 0.63万
  • 项目类别:
APPROACHES TO IMPROVE PROTEIN FOOTPRINTING: HIGH PRESSURE DIGESTION
改善蛋白质足迹的方法:高压消化
  • 批准号:
    8361405
  • 财政年份:
    2011
  • 资助金额:
    $ 0.63万
  • 项目类别:
UNDERGRADUATE TRAINING IN MASS SPECTROMETRY
质谱学本科培训
  • 批准号:
    8361432
  • 财政年份:
    2011
  • 资助金额:
    $ 0.63万
  • 项目类别:
VISITING SCIENTISTS
访问科学家
  • 批准号:
    8361338
  • 财政年份:
    2011
  • 资助金额:
    $ 0.63万
  • 项目类别:
STRUCTURAL STUDIES OF GRAMICIDIN & OTHER SELF-ASSOCIATING PEPTIDES
短杆菌肽的结构研究
  • 批准号:
    8361321
  • 财政年份:
    2011
  • 资助金额:
    $ 0.63万
  • 项目类别:
CONTRIBUTED PRESENTATIONS AT CONFERENCES
在会议上发表演讲
  • 批准号:
    8361333
  • 财政年份:
    2011
  • 资助金额:
    $ 0.63万
  • 项目类别:

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