Pennsylvania: Multi-Site Study of the Health Implications of Exposure to PFAS-Contaminated Drinking Water

项目摘要/摘要 宾夕法尼亚州巴克斯县Warminster镇的前海军空军作战中心和Horsham空军卫队 宾夕法尼亚州蒙哥马利县霍舍姆镇的一个车站被发现是广泛传播的 饮用水受到全氟烷基物质和多氟烷基物质(PFAS)的污染，由于 几十年。饮用水污染归因于使用含全氟辛烷磺酸的水性成膜泡沫 军事训练演习中使用的灭火剂(AFFF)。PA站点的特点是高 规模大，持续时间长，暴露范围广。国际RTI，宾夕法尼亚州卫生部 (DOH)、布朗大学和坦普尔大学提议联合在PA现场进行研究，作为 ATSDR的多站点研究。拟议的地点人口稠密(&gt；80,000)，并已核实全氟辛烷 公共供水系统(PWS)和私人水井中的磺酸和全氟辛酸污染。合资格 在过去的15年里，4-17岁的成年人和儿童都会接触到这种病毒。成年人职业性接触 化学制造、消防员或在使用AFFF进行消防训练期间的PFAS将被排除在外 从这项研究中。同样，生母是职业接触者的孩子将不符合条件。一个 将采用两阶段整群抽样设计，第一阶段选择家庭，然后是 通过对家庭中的所有成年人和儿童进行抽样。与试点生物监测的结果一致 由卫生局卫生署进行的努力，距离两个军事基地最近的PWS服务的住宅的血清水平较高 全氟辛烷磺酸水平，并将进行过抽样。总共将招募2000名成年人和800名儿童 参与研究，并将完成ATSDR的核心议定书，包括同意和面谈， 人体测量、神经行为评估和生物样品(血液和尿液)采集。 除了收集2800名参与者的核心数据外，PFAS的历史水资源重建 将对现场周围的饮用水进行浓缩。药代动力学模型将会是 进行以估计非职业接触者的历史血清浓度。两名调查员- 还提出了启动研究活动的建议。首先，将先进的空间分析方法应用于 模拟全氟辛烷磺酸暴露和其他潜在癌症决定因素随时间变化与一系列癌症的关系 终端。第二，将利用暴露估计来对肾脏和 使用以家庭为基础的设计来治疗甲状腺癌。包括巴勒斯坦权力机构网站和调查员发起的 本申请中提出的研究将对ATSDR多站点的范围和严密性做出重大贡献 全氟辛烷磺酸环境健康研究。

PROJECT SUMMARY/ABSTRACT A former Naval Air Warfare Center in Warminster Township, Bucks County, PA, and the Horsham Air Guard Station in Horsham Township, Montgomery County, PA, have been found to be the source of widespread drinking water contamination from per- and polyfluoroalkyl substances (PFAS) that went undetected for decades. Drinking water contamination was attributed to use of PFAS-containing aqueous film-forming foam (AFFF), a fire suppressant used in military training exercises. The PA site is characterized by high magnitude, long duration, and wide-ranging exposure. RTI International, the PA Department of Health (DOH), Brown University, and Temple University propose to jointly conduct research at the PA site as part of ATSDR's multisite study. The proposed site is densely populated (>80,000) and has verified perfluorooctane sulfonate and perfluorooctanoic acid contamination in public water systems (PWS) and private wells. Eligible adults and children ages 4–17 will have been exposed in the last 15 years. Adults occupationally exposed to PFAS in chemical manufacture, as a firefighter, or during fire training exercises using AFFF, will be excluded from the study. Likewise, children whose birth mothers were occupationally exposed will not be eligible. A two-stage clustered sampling design will be employed, with households selected in the first stage, followed by the sampling of all adults and children in households. Consistent with findings from a pilot biomonitoring effort conducted by PA DOH, residences served by PWS closest to the two military bases had higher serum PFAS levels and will be oversampled. A total of 2,000 adults and 800 children will be recruited for participation in the study and will complete ATSDR's core protocol, including consenting and interviewing, anthropometric measurements, neurobehavioral assessments, and biospecimen (blood and urine) collection. In addition to collecting core data on 2,800 participants, historical water reconstruction of PFAS concentrations in drinking water around the site will be conducted. Pharmacokinetic modeling will be conducted to estimate historical serum concentrations of nonoccupational-exposed people. Two investigator- initiated research activities are also proposed. First, advanced spatial analysis methods will be applied to model PFAS exposure and other potential cancer determinants over time in relation to a range of cancer endpoints. Second, exposure estimates will be leveraged to conduct a focused investigation of kidney and thyroid cancers using a family-based design. The inclusion of the PA site and the investigator-initiated research proposed in this application will contribute significantly to the scope and rigor of ATSDR's multisite PFAS environmental health study.