Tulane National Primate Research Center AIDS SPF Breeding Colony Maintenance

项目摘要/摘要--总体 杜兰国家灵长类动物研究中心(TNPRC)拥有最大的恒河猴繁殖群体之一 在美国。本申请的目的是为继续支持和维护申请资金 在TNPRC，U42支持SPF印度源恒河猴繁育群体。具体目标 涉及融资机会公告(FOA)中指定的组件，并分为 总体计划描述、畜牧和管理核心、病毒检测核心和MHC基因分型 核心。计划收入和TNPRC资金将用于支持计划中未涵盖的部分 资助金包括：超过本申请所支持的动物的任何群体动物的每日津贴， 需要对这些动物进行额外的测试，基础设施的修复和改善，兽医临床和 病理支持、行为管理支持和部分基因测试。 具体目标： 总的来说。维护现有的SPF群体，并将可用的动物分发给NIH资助的艾滋病毒/艾滋病 研究社区。 畜牧业和管理核心。为SPF繁殖群体提供畜牧和兽医护理 在现有的U42拨款中设立。这包括一项强有力的临床兽医保健计划和 行为管理。种群已达到成熟的自给自足状态，具有理想的人口结构 根据生产和需求，每年生产多达105-150只可供分配的动物。计划 动物销售产生的收入将返还到一个账户，用于支持赠款的目标。 病毒检测核心。通过对现有育种进行持续的病毒测试，确保种群的SPF状态 群居动物和所有后代。继续将菌落的特性扩展到所需的4种病毒之外 包括麻疹病毒、SARS-CoV-2、克氏锥虫和其他新出现的传染病 威胁非人类灵长类动物的疾病。 MHC基因分型核心。继续对菌落进行遗传分析和MHC分型，并提供扩大的 通过改进的技术进行基因表征。

Project Summary/Abstract - Overall The Tulane National Primate Research Center (TNPRC) has one of the largest rhesus monkey breeding colonies in the United States. The objective of this application is to request funds for continued support and maintenance of the U42 supported SPF Indian-origin rhesus monkey breeding colony at the TNPRC. The specific aims address the components specified in the funding opportunity announcement (FOA) and are divided into the Overall program description, Husbandry and Management Core, Viral Testing Core, and MHC Genetic Typing Core. Program income and TNPRC funds will be used to support components of the program not covered by grant funds including: per diem for any colony animals in excess of the animals supported by this application, additional testing required for those animals, infrastructure repairs and improvements, veterinary clinical and pathology support, behavioral management support, and portions of the genetic testing. Specific Aims: Overall. To maintain the existing SPF colony and distribute available animals to the NIH funded HIV/AIDS research community. Husbandry and Management Core. To provide husbandry and veterinary care for the SPF breeding colony established in the existing U42 grant. This includes a robust program for clinical veterinary medical care and behavioral management. The colony has reached a mature self-sustaining status with ideal demographics to produce up to 105-150 animals available for assignment each year based on production and demand. Program income generated by the animal sales will be returned to an account for use in supporting the aims of the grant. Viral Testing Core. To assure the SPF status of the colony through continued viral testing of existing breeding colony animals and all offspring. Continue to expand characterization of the colony beyond the required 4 viruses to include agents such as measles virus, SARS-CoV-2, Trypanosoma cruzi, and other emerging infectious diseases that threaten nonhuman primates. MHC Genetic Typing Core. To continue genetic analysis and MHC typing of the colony and provide expanded genetic characterization through enhanced techniques.