Tulane National Primate Research Center AIDS SPF Breeding Colony Maintenance

杜兰国家灵长类研究中心 AIDS SPF 繁殖群体维护

• 批准号: 10808529
• 负责人: RUDOLF Paul BOHM
• 金额: $ 50万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10808529
• 关键词: Accounting; Acquired Immunodeficiency Syndrome; Animals; Applied Research; Award; Basic Science; Behavioral; Biomedical Research; Breeding; COVID-19 pandemic; Caring; Clinical; Dedications; Equilibrium; Event; Foundations; Funding; Funding Agency; Future; Grant; Health; Herpesvirus 1; Housing; Human; Income; Infant; Infrastructure; Knowledge; Macaca; Macaca mulatta; Maintenance; Measures; Medical; Mission; Modeling; Parents; Pathogenesis; Personal Satisfaction; Primates; Privatization; Production; Research; Research Infrastructure; Research Personnel; Resources; Retroviridae; SIV; Sales; Scientific Advances and Accomplishments; Scientist; Simian T-lymphotropic virus 1; Testing; United States; United States National Institutes of Health; Weather; Well in self; base; co-infection; demographics; design; germ free condition; improved; microbicide; nonhuman primate; pre-exposure prophylaxis; programs; repaired; social; transmission process; vaccine development

PROJECT SUMMARY/ABSTRACT The Tulane National Primate Research Center (TNPRC) is one of seven National Primate Research Centers (NPRCs) sponsored by the National Institutes of Health. The Center is dedicated to providing the infrastructure and support for basic and applied research efforts to advance scientific knowledge and improve human and animal health and wellbeing. The TNPRC has one of the largest specific pathogen free (SPF) rhesus monkey breeding colonies in the United States. Over the past 5 years, this breeding colony produced between 595-957 infants annually and provided close to 2,000 animals for biomedical research programs, including those focused on AIDS. Award U42OD024282 funds the establishment and maintenance of the TNPRC SPF breeding colony to support AIDS research. The TNPRC AIDS research program is the largest at the Center, currently accounting for 61% of all grant funding and 67% of animals assigned to research at the TNPRC on an annual basis. The SPF breeding colony also provides rhesus macaques to affiliate investigators outside of the TNPRC for AIDS research. In 2022, 361 SPF rhesus macaques were requested for AIDS research by TNPRC and affiliate investigators. Of those, 312 have been allocated with the remainder awaiting assignment. Essentially all SPF rhesus monkeys utilized in AIDS research programs at the TNPRC are derived from the U42-supported TNPRC breeding colony. The TNPRC SPF program supports a variety of AIDS-related studies, including vaccine development, pre-exposure prophylaxis, microbicides, AIDS/TB coinfection, transmission pathogenesis, and cure research. Currently, there is high national demand for SPF macaques which requires the continued availability and enhancement of this resource. The proposed supplement to the U42 will be used to renovate an existing housing enclosure unit that has been decommissioned. The renovation will bring the facility to state-of-the-art status and incorporate additional measures to protect animals during inclement weather events. The housing enclosure renovation is within the scope of the of the parent award and does not overlap with any U42-funded projects. The benefits realized from this improvement will expand the TNPRC SPF rhesus macaque research infrastructure to assure these colonies are sustainable and able to provide high-quality research models well into the future.

项目总结/摘要 杜兰国家灵长类动物研究中心（TNPRC）是七个国家灵长类动物研究中心之一。 （NPRCs）由美国国立卫生研究院赞助。该中心致力于提供基础设施 支持基础和应用研究工作，以促进科学知识和提高人类和 动物健康和福祉。TNPRC拥有最大的无特定病原体（SPF）恒河猴之一 在美国的繁殖地。在过去的5年里，这个繁殖地生产了595-957只 每年为婴儿提供近2,000只动物用于生物医学研究项目，包括那些专注于 关于艾滋病 U42 OD 024282奖资助建立和维护TNPRC SPF繁殖群，以支持 艾滋病研究。TNPRC艾滋病研究项目是该中心最大的项目，目前占61% 所有赠款资金和67%的动物分配到研究在TNPRC每年的基础上。的SPF 繁殖基地还向TNPRC以外的艾滋病附属调查人员提供恒河猴 research. 2022年，361只SPF恒河猴被TNPRC及其附属机构要求用于艾滋病研究 investigators.其中312人已分配，其余人等待分配。基本上所有SPF 在坦桑尼亚联合共和国艾滋病研究项目中使用的恒河猴来自U42支持的坦桑尼亚联合共和国 繁殖群体TNPRC SPF计划支持各种艾滋病相关研究，包括疫苗 发展、暴露前预防、杀微生物剂、艾滋病/结核病合并感染、传播发病机制，以及 治愈研究目前，全国对SPF猕猴的需求很高，需要继续 这一资源的可用性和增强。 U42的拟议补充将用于翻新现有的住房封闭单元， 退役了翻修将使该设施达到最先进的水平，并增加 在恶劣天气事件中保护动物的措施。房屋围挡改造在 该项目的范围与母项目的范围相同，并且不与任何U42资助的项目重叠。实现的效益 这一改进将扩大TNPRC SPF恒河猴研究基础设施，以确保这些群体 可持续发展，并能够为未来提供高质量的研究模型。