Tulane National Primate Research Center AIDS SPF Breeding Colony Maintenance

杜兰国家灵长类研究中心 AIDS SPF 繁殖群体维护

• 批准号: 10252430
• 负责人: RUDOLF Paul BOHM
• 金额: $ 221.18万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10252430
• 关键词: 2019-nCoV; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Animal Testing; Animals; Award; Behavioral; Breeding; Caring; Clinical; Clinical Pathology; Communities; Cost Savings; Country; Databases; Disease; Emerging Communicable Diseases; Ensure; Equilibrium; Exclusion; Funding; Funding Agency; Funding Opportunities; Genetic; Genetic Variation; Goals; Grant; Human Resources; Income; Individual; Infectious Agent; Infrastructure; Investigation; Investments; Leadership; Link; Macaca mulatta; Maintenance; Measles virus; Medical; Monitor; Opportunistic Infections; Population; Population Genetics; Population Sizes; Primates; Procedures; Process; Production; Program Description; Records; Research; Research Personnel; Research Project Grants; Resources; Sales; Source; Specific qualifier value; Techniques; Testing; Time; Trypanosoma cruzi; United States; United States National Institutes of Health; Viral; Virus; Wages; Writing; animal colony; base; congenital infection; data management; demographics; experience; genetic analysis; genetic testing; germ free condition; immunosuppressed; nonhuman primate; offspring; programs; repaired; success; vaccine development

Project Summary/Abstract - Overall The Tulane National Primate Research Center (TNPRC) has one of the largest rhesus monkey breeding colonies in the United States. The objective of this application is to request funds for continued support and maintenance of the U42 supported SPF Indian-origin rhesus monkey breeding colony at the TNPRC. The specific aims address the components specified in the funding opportunity announcement (FOA) and are divided into the Overall program description, Husbandry and Management Core, Viral Testing Core, and MHC Genetic Typing Core. Program income and TNPRC funds will be used to support components of the program not covered by grant funds including: per diem for any colony animals in excess of the animals supported by this application, additional testing required for those animals, infrastructure repairs and improvements, veterinary clinical and pathology support, behavioral management support, and portions of the genetic testing. Specific Aims: Overall. To maintain the existing SPF colony and distribute available animals to the NIH funded HIV/AIDS research community. Husbandry and Management Core. To provide husbandry and veterinary care for the SPF breeding colony established in the existing U42 grant. This includes a robust program for clinical veterinary medical care and behavioral management. The colony has reached a mature self-sustaining status with ideal demographics to produce up to 105-150 animals available for assignment each year based on production and demand. Program income generated by the animal sales will be returned to an account for use in supporting the aims of the grant. Viral Testing Core. To assure the SPF status of the colony through continued viral testing of existing breeding colony animals and all offspring. Continue to expand characterization of the colony beyond the required 4 viruses to include agents such as measles virus, SARS-CoV-2, Trypanosoma cruzi, and other emerging infectious diseases that threaten nonhuman primates. MHC Genetic Typing Core. To continue genetic analysis and MHC typing of the colony and provide expanded genetic characterization through enhanced techniques.

项目概要/摘要-总体 杜兰国家灵长类动物研究中心（TNPRC）拥有最大的恒河猴繁殖群之一， 在美国此申请的目的是请求资金用于继续支持和维护 U42支持的SPF印度恒河猴繁殖群。具体目标 解决融资机会公告（FOA）中指定的组件，并分为 总体计划描述，畜牧和管理核心，病毒检测核心和MHC基因分型 核心计划收入和TNPRC资金将用于支持计划中未涵盖的部分， 补助金包括：任何超出本申请所支持的动物的群体动物的每日津贴， 这些动物需要额外的测试，基础设施的维修和改善，兽医临床和 病理支持、行为管理支持和部分基因检测。 具体目标： 总的来说。维持现有的SPF群体，并将可用的动物分配给NIH资助的艾滋病毒/艾滋病 研究社区。 畜牧业和管理核心。为SPF繁殖群提供饲养和兽医护理 在现有的U42补助金中设立。这包括一个强大的临床兽医医疗保健计划， 行为管理殖民地已达到成熟的自我维持状态， 根据生产和需求，每年生产105-150只动物可供分配。程序 出售动物所得的收入会拨入一个帐户，以支持拨款的目的。 病毒检测核心。通过对现有育种进行持续病毒检测，确保殖民地的SPF状态 群体动物和所有后代。继续扩展殖民地的表征，超出所需的4种病毒 包括麻疹病毒、SARS-CoV-2、克氏锥虫和其他新出现的传染性疾病， 威胁非人类灵长类动物的疾病 MHC基因分型核心。继续对殖民地进行遗传分析和MHC分型， 通过强化技术进行基因鉴定。