Husbandry and Management Core

项目摘要/摘要-畜牧业和管理核心 杜兰国家灵长类动物研究中心(TNPRC)拥有最大的恒河猴繁殖群体之一 在美国。这一资源几十年来一直为美国国立卫生研究院资助的艾滋病毒/艾滋病研究项目提供动物 是该中心成功研究计划的关键组成部分。因为超过一半的研究 TNPRC的项目是由附属(非TNPRC)调查人员发起的，这一资源对 许多由美国国立卫生研究院资助的调查人员在全美取得成功。TNPRC有很长的派生历史， 发展和管理大型猕猴繁殖群体。多年殖民地生活的经验 管理是成功建立U42 SPF菌落和 达到了将整个TNPRC恒河猴群体转换为SPF状态的目标。TNPRC已经 重点关注持续改进的哲学，这是通过使用证据来培养的，源于 观察、受控的科学研究和推动决策的文献。这一理念被采用了 在该计划的许多领域，包括住房、行为管理、畜牧实践、苗圃饲养、 预防医学和临床兽医护理。本申请的目的是申请资金，用于 继续支持和维护TNPRC的SPF恒河猴繁育群体。这个 维护U42繁育群体需要将动物护理计划的许多方面整合在 TNPRC包括兽医护理、行为管理、基因监测和病毒检测，以确保SPF 殖民地的状态。这一部分描述了蜂群的饲养和管理，重点是日常 护理操作、行为管理和临床护理。 这个核心的具体目标是为建立的SPF繁殖群体提供畜牧和兽医护理 在现有的U42拨款中。这包括针对临床护理和行为管理的强有力的计划。殖民地 已达到约1400只动物的成熟状态(SPF4 n=1269；ESPF n=131)，具有理想的 根据生产和需求，人口统计每年生产多达150只动物用于研究任务。 出售动物所产生的计划收入将返还到一个账户，用于支持AIMS 拨款的一部分。

Project Summary/Abstract - Husbandry and Management Core The Tulane National Primate Research Center (TNPRC) has one of the largest rhesus monkey breeding colonies in the US. This resource has provided animals for NIH funded HIV/AIDS research projects for several decades and is a critical component of the Center's successful research program. Because over half of all research projects at TNPRC are initiated by Affiliate (non-TNPRC) investigators, this resource is essential to the success of many NIH-funded investigators throughout the US. The TNPRC has a long history of deriving, developing, and managing large macaque breeding colonies. The experience derived from many years of colony management is a significant contributing factor to the successful establishment of the U42 SPF colony and achieving the goal of converting the entire TNPRC rhesus monkey colony to SPF status. The TNPRC has focused on a philosophy of continuous improvement, which is fostered by the use of evidence, derived from observation, controlled scientific study, and the literature to drive decision making. This philosophy is employed in many areas of the program including housing, behavioral management, husbandry practices, nursery rearing, preventive medicine, and clinical veterinary care. The objective of this application is to request funds for continued support and maintenance of this SPF rhesus monkey breeding colony at the TNPRC. The maintenance of the U42 breeding colony requires the integration of many aspects of the animal care program at TNPRC including veterinary care, behavioral management, genetic monitoring, and viral testing to ensure SPF status of the colony. This section describes the husbandry and management of the colony and focuses on daily care operations, behavioral management, and clinical care. The Specific Aim of this core is to provide husbandry and veterinary care for the SPF breeding colony established in the existing U42 grant. This includes robust programs for clinical care and behavioral management. The colony has reached a mature status of approximately 1400 animals (SPF4 n=1269; eSPF n=131) with ideal demographics to produce up to 150 animals per year for research assignment based on production and demand. Program Income generated by the sale of animals will be returned to an account for use in supporting the aims of the grant.