SPECIFIC PATHOGEN FREE RHESUS MONKEY COLONY FOR AIDS RESEARCH

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 背景：两项赠款(U24、U42)为艾滋病SPF群体的建立提供资金。方法：最初动物来源于TNPRC常规繁育群体。动物的SIV、STLV-1、SRV和B-病毒均为阴性。所有来自艾滋病SPF群体的动物都被限制在艾滋病研究项目的分配范围内。该殖民地的人口普查大约在2001年，符合预测。其中71只动物被分配到扩展的SPF计划中。结果/讨论：2010年，向附属机构和核心调查人员提供了215只SPF恒河猴。此外，在繁殖群体中还出现了对动物的背负使用。包括血液、粪便、唾液和骨髓在内的组织被提供给研究人员，以支持他们的研究计划。还收集了行为/观察数据，以支持研究和管理计划。所有对动物的背负式使用都是非侵入性的或微侵入性的，允许动物留在它们的社会群体中，不影响生产。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background: Two grants (U24, U42) provide funding for derivation of the AIDS SPF colony. Methods: Initially animals were derived from the TNPRC conventional breeding colony. Animals are negative for SIV, STLV-1, SRV, and B-virus. All animals from the AIDS SPF colonies are limited to assignment to AIDS research projects. The census of the colony is approximately 2001, which meets projections. Seventy-one of the animals are assigned to the expanded SPF program. Results/Discussion: In 2010, 215 SPF rhesus were made available for assignment to affiliate and core investigators. In addition, piggybacked use of animals in the breeding colony occurred. Tissues, including blood, feces, saliva, and bone marrow, were provided to investigators to support their research programs. Behavioral/observational data were also collected to support research and management programs. All piggyback use of animals is noninvasive or minimally invasive and allows animals to remain in their social groups with no impact to production.