SPECIFIC PATHOGEN FREE RHESUS MONKEY COLONY FOR AIDS RESEARCH

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 表示子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 背景：两项赠款（U24，U42）为艾滋病SPF群体的产生提供资金。 方法：最初动物来自TNPRC常规繁殖群。 动物对SIV、STLV-1、SRV和B病毒呈阴性。 来自艾滋病SPF群体的所有动物仅限于分配给艾滋病研究项目。 殖民地的人口普查大约在2001年进行，符合预测。其中71只动物被分配到扩大的SPF计划。 结果/讨论：2010年，215只SPF恒河猴可分配给附属研究者和核心研究者。 此外，在繁殖群中发生了背驮使用动物的情况。 向研究者提供组织，包括血液、粪便、唾液和骨髓，以支持他们的研究计划。 还收集了行为/观察数据，以支持研究和管理计划。所有背驮动物的使用都是无创或微创的，并允许动物留在它们的社会群体中，而不会影响生产。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background: Two grants (U24, U42) provide funding for derivation of the AIDS SPF colony. Methods: Initially animals were derived from the TNPRC conventional breeding colony. Animals are negative for SIV, STLV-1, SRV, and B-virus. All animals from the AIDS SPF colonies are limited to assignment to AIDS research projects. The census of the colony is approximately 2001, which meets projections. Seventy-one of the animals are assigned to the expanded SPF program. Results/Discussion: In 2010, 215 SPF rhesus were made available for assignment to affiliate and core investigators. In addition, piggybacked use of animals in the breeding colony occurred. Tissues, including blood, feces, saliva, and bone marrow, were provided to investigators to support their research programs. Behavioral/observational data were also collected to support research and management programs. All piggyback use of animals is noninvasive or minimally invasive and allows animals to remain in their social groups with no impact to production.