Neural and developmental trajectories of females with autism spectrum disorder

患有自闭症谱系障碍的女性的神经和发育轨迹

• 批准号: 10443473
• 负责人: Christine Wu Nordahl
• 金额: $ 79.63万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10443473
• 关键词: 12 year old; 6 year old; Address; Age; Amygdaloid structure; Area; Attention deficit hyperactivity disorder; Attenuated; Behavioral; Biological Markers; Brain; Brain region; Caring; Data; Detection; Development; Diagnosis; Diagnostic; Disease; Emotional; Enrollment; Etiology; Exhibits; Female; Feminization; Gender; General Population; Goals; Hyperactivity; Impulsivity; Individual; Knowledge; Lead; Literature; Longevity; Longitudinal Studies; Longitudinal cohort; Masculine; Medicine; Modeling; Participant; Pattern; Prevalence; Protocols documentation; Psychopathology; Research; Risk Factors; Sampling; Sampling Studies; Self-Injurious Behavior; Sex Differences; Strategic Planning; Symptoms; System; Testing; Theoretical model; Time; United States Dept. of Health and Human Services; United States National Institutes of Health; Woman; Women' s Health; attenuation; autism spectrum disorder; autistic; base; behavioral phenotyping; boys; cohort; disorder risk; early childhood; emotion dysregulation; emotion regulation; ethnic minority population; externalizing behavior; girls; imaging study; inattention; individuals with autism spectrum disorder; insight; male; middle childhood; neuroimaging; optimal treatments; outcome prediction; peer; phenome; programs; protective effect; racial minority; recruit; relating to nervous system; restrictive repetitive behavior; sensorimotor system; serial imaging; sex; theories

Girls and women are understudied in autism spectrum disorder (ASD) research because study samples often reflect the male predominance in ASD prevalence, with 3-4 boys diagnosed for every girl. Longitudinal imaging studies with sufficient numbers of females are completely lacking. To address this important gap in knowledge, we aim to evaluate brain and behavioral trajectories from early to middle childhood in a large, longitudinal cohort of nearly 100 girls with autism. As the field moves towards identifying neural biomarkers for ASD risk and predicting outcomes, it is critical to understand similarities and differences between males and females with ASD across the lifespan. Another serious need is to better understand co-occurring psychiatric conditions in females with ASD. It is well-recognized that individuals with autism have high rates of co-occurring psychopathology, but little is known about early behavioral and neural risk factors that may be specific to girls. As in so many other areas of medicine, the optimal treatment of girls and women with ASD will only emerge when sex-related autism attributes and problems are adequately understood. In 2014, we established the Girls with Autism – Neuroimaging of Development (GAIN) study, which increased representation of females with ASD in a larger ongoing project called the Autism Phenome Project and followed a cohort of girls across three time points from 2-6 years of age. With this application, we plan to conduct a fourth longitudinal time point in GAIN participants during middle childhood (9-12 years of age). In addition, in order to increase generalizability of findings, we plan to enroll new girls into the study with a focus on racial and ethnic minority groups that have historically been under-represented. Newly enrolled girls will follow the same study protocols established by the GAIN study and data will be combined. We propose the following aims: 1) To identify sex-specific neural and behavioral patterns in girls with ASD in early and middle childhood. 2) To identify sex differences in neural risk factors associated with symptoms of internalizing and externalizing psychopathology in middle childhood. 3) To characterize the emergence and impact of symptoms of attention deficit/hyperactivity disorder (ADHD) in girls with ASD. Evaluating females with ASD is a cross-cutting goal that spans all objectives of the US Department of Health & Human Services Interagency Autism Coordinating Committee and is also consistent with the goals of the Trans-NIH Strategic Plan for Women’s Health Research.

女孩和妇女在自闭症谱系障碍 (ASD) 研究中的研究不足，因为研究样本经常 反映了自闭症谱系障碍患病率中男性占主导地位，每个女孩对应 3-4 个被诊断出的男孩。纵向成像 完全缺乏对足够数量的女性进行的研究。为了解决这一重要的知识差距， 我们的目标是在大型纵向研究中评估从幼儿期到中期的大脑和行为轨迹 近100名患有自闭症的女孩组成的队列。随着该领域朝着识别自闭症谱系障碍 (ASD) 风险的神经生物标志物方向发展 和预测结果，了解男性和女性之间的异同至关重要 患有 ASD 的整个生命周期。另一个迫切需要是更好地了解同时发生的精神疾病 患有 ASD 的女性。众所周知，患有自闭症的人有很高的共患率 精神病理学，但人们对女孩特有的早期行为和神经危险因素知之甚少。 与许多其他医学领域一样，患有自闭症谱系障碍的女孩和妇女的最佳治疗方法只会出现 当与性相关的自闭症属性和问题得到充分理解时。 2014年，我们成立了女孩 自闭症——发育神经影像（GAIN）研究，该研究增加了患有自闭症的女性的比例 自闭症谱系障碍 (ASD) 参与了一个更大的正在进行的项目，称为“自闭症现象组项目”，跟踪了一群跨越三个年龄段的女孩 时间点为2-6岁。通过此应用程序，我们计划在 吸引儿童中期（9-12 岁）的参与者。另外，为了增加普适性 根据调查结果，我们计划让新女孩参加这项研究，重点关注那些拥有 历史上代表性不足。新入学的女孩将遵循由 GAIN 研究和数据将被合并。我们提出以下目标：1）识别性别特异性神经元 以及患有自闭症谱系障碍的女孩在童年早期和中期的行为模式。 2）识别神经元的性别差异 与童年中期内化和外化精神病理学症状相关的危险因素。 3) 描述注意力缺陷/多动障碍 (ADHD) 症状的出现和影响 患有自闭症谱系障碍的女孩。评估患有自闭症谱系障碍的女性是一个跨领域目标，涵盖美国的所有目标 卫生与公众服务部机构间自闭症协调委员会也一致 与跨 NIH 女性健康研究战略计划的目标。