Neural Phenotypes of Females with Autism Spectrum Disorder
患有自闭症谱系障碍的女性的神经表型
基本信息
- 批准号:9248812
- 负责人:
- 金额:$ 66.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-07-10 至 2019-03-31
- 项目状态:已结题
- 来源:
- 关键词:3 year old5 year oldAdolescenceAffectAgeAmygdaloid structureAttenuatedAutistic DisorderAutoantibodiesBehavior assessmentBiologicalBrainBrain regionChildChildhoodComorbidityCopy Number PolymorphismDataDevelopmentDiagnosisDiffusionDiseaseDorsalEnrollmentEnvironmental Risk FactorEtiologyEvaluationFemaleFibrinogenFusiform gyrusGenesGeneticGenetic LoadGoalsGrowthHeterogeneityHigh PrevalenceImageIndividualInstitutesInsulin-Dependent Diabetes MellitusInvestigationLifeMagnetic Resonance ImagingMalignant Childhood NeoplasmMedialMegalencephalyMissionModelingNeuronsNursery SchoolsParticipantPhenotypePrefrontal CortexPrevalenceRecruitment ActivityResearchResearch Domain CriteriaRestSample SizeSamplingSex BiasSex CharacteristicsSex RatioStrategic PlanningStructure of superior temporal sulcusSubgroupSystemTimeUnited StatesUnited States National Institutes of HealthVentral StriatumWomen&aposs HealthWorkagedautism spectrum disorderbehavior testbehavioral outcomeboysbrain abnormalitiescohortcommunication behaviordiffusion weightedgirlshealth differenceleukemiamaleneuropathologyphenomeprogramsprotective effectpublic health relevancerelating to nervous systemrepetitive behaviorresearch studysexsexual dimorphismsocial communicationsocial communication impairmentwhite matter
项目摘要
DESCRIPTION (provided by applicant): Autism spectrum disorder (ASD) affects 1 in 88 children in the United States, but the disorder is much more common in boys than in girls. The prevalence of ASD in boys is 5 times higher than in girls, with a rate of 1 in 54 for boys and 1 in
252 for girls. Although this disparate sex ratio is among the most highly replicated findings in studies of ASD, sex differences in ASD remain poorly understood. The neuropathology of ASD in females is understudied because ASD samples recruited for research studies typically reflect the strong male bias of the disorder. The goal of this study is to evaluate a large, sex-balanced cohort of preschool-aged children with ASD in order to elucidate the neural phenotypes of females with ASD and to identify sex-differences in the neuropathology of ASD. Children will be enrolled at the time of diagnosis (2-3 years of age) and followed longitudinally for two years. Imaging will be carried out at study enrolment and then at two additional annual time points and behavioral testing will be conducted twice, in conjunction with the first and third MRI time points Imaging will include structural, diffusion-weighted and resting state functional connectivity in order to accomplish the following aims: 1) to evaluate sex differences in the neural systems that underlie core deficits in ASD 2) to investigate sex differences in brain growth trajectories in these neural systems and 3) to identify associations between distinct neural phenotypic subgroups and etiologic factors or behavioral outcomes. A comprehensive understanding of the female phenotype of ASD is a pressing and timely topic, as indicated by national efforts to direct research towards this topic. This program of research responds to the Interagency Autism Coordinating Committee (IACC) strategic plan to evaluate females with ASD as well as the mission of the NIH Office of Research on Women's Health to strengthen and enhance research related to diseases, disorders and conditions that affect females.
描述(由申请人提供):在美国,每88名儿童中就有1名患有自闭症谱系障碍(ASD),但这种疾病在男孩中比女孩更常见。男孩的自闭症患病率是女孩的5倍,男孩的患病率是1 / 54,男孩的患病率是1 / 54
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Christine Wu Nordahl其他文献
19.2 SEX DIFFERENCES IN AMYGDALA DEVELOPMENT IN AUTISM SPECTRUM DISORDER FROM EARLY TO MIDDLE CHILDHOOD
- DOI:
10.1016/j.jaac.2021.07.662 - 发表时间:
2021-10-01 - 期刊:
- 影响因子:
- 作者:
Christine Wu Nordahl - 通讯作者:
Christine Wu Nordahl
Correction: Video Game Use, Aggression, and Social Impairment in Adolescents with Autism Spectrum Disorder
- DOI:
10.1007/s10803-022-05694-w - 发表时间:
2022-07-29 - 期刊:
- 影响因子:2.800
- 作者:
Konnor Davis;Ana-Maria Iosif;Christine Wu Nordahl;Marjorie Solomon;Marie K. Krug - 通讯作者:
Marie K. Krug
Sex Differences in the Striatal Contributions to Longitudinal Fine Motor Development in Autistic Children
自闭症儿童纹状体对纵向精细运动发展的性别差异
- DOI:
10.1016/j.biopsych.2025.01.005 - 发表时间:
2025-06-15 - 期刊:
- 影响因子:9.000
- 作者:
Olivia Surgent;Derek S. Andrews;Joshua K. Lee;Joseph Boyle;Andrew Dakopolos;Meghan Miller;Sally Ozonoff;Sally J. Rogers;Marjorie Solomon;David G. Amaral;Christine Wu Nordahl - 通讯作者:
Christine Wu Nordahl
Erratum: Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder
- DOI:
10.1186/s13229-015-0030-3 - 发表时间:
2015-06-20 - 期刊:
- 影响因子:5.500
- 作者:
Christine Wu Nordahl;Ana-Maria Iosif;Gregory S Young;Lee Michael Perry;Robert Dougherty;Aaron Lee;Deana Li;Michael H Buonocore;Tony Simon;Sally Rogers;Brian Wandell;David G Amaral - 通讯作者:
David G Amaral
Christine Wu Nordahl的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Christine Wu Nordahl', 18)}}的其他基金
Neural and developmental trajectories of females with autism spectrum disorder
患有自闭症谱系障碍的女性的神经和发育轨迹
- 批准号:
10614560 - 财政年份:2022
- 资助金额:
$ 66.55万 - 项目类别:
Neural and developmental trajectories of females with autism spectrum disorder
患有自闭症谱系障碍的女性的神经和发育轨迹
- 批准号:
10443473 - 财政年份:2022
- 资助金额:
$ 66.55万 - 项目类别:
Behavioral and Neurobiological Phenotyping of ASD with Megalencephaly
自闭症谱系障碍(ASD)伴巨脑畸形的行为和神经生物学表型
- 批准号:
10238007 - 财政年份:2017
- 资助金额:
$ 66.55万 - 项目类别:
Neural Phenotypes of Females with Autism Spectrum Disorder
患有自闭症谱系障碍的女性的神经表型
- 批准号:
8749078 - 财政年份:2014
- 资助金额:
$ 66.55万 - 项目类别:
Analyses of Brain Structure and Connectivity in Young Children with Autism
自闭症幼儿的大脑结构和连接性分析
- 批准号:
8519565 - 财政年份:2011
- 资助金额:
$ 66.55万 - 项目类别:
PROTEOMIC PROFILING OF INTEGRAL MEMBRANE PROTEIN TOPOLOGY
整体膜蛋白拓扑结构的蛋白质组学分析
- 批准号:
8365856 - 财政年份:2011
- 资助金额:
$ 66.55万 - 项目类别:
IDENTIFICATION OF HUMAN PROTEINS IN A MOUSE XENOGRAPH MODEL
小鼠异种模型中人类蛋白质的鉴定
- 批准号:
8365848 - 财政年份:2011
- 资助金额:
$ 66.55万 - 项目类别:
Analyses of Brain Structure and Connectivity in Young Children with Autism
自闭症幼儿的大脑结构和连接性分析
- 批准号:
8299854 - 财政年份:2011
- 资助金额:
$ 66.55万 - 项目类别:
Analyses of Brain Structure and Connectivity in Young Children with Autism
自闭症幼儿的大脑结构和连接性分析
- 批准号:
8320314 - 财政年份:2011
- 资助金额:
$ 66.55万 - 项目类别:
相似海外基金
The Language Environment in Fostering 5-Year-Old Children's Voluntary Involvements
培养5岁儿童自愿参与的语言环境
- 批准号:
22K13681 - 财政年份:2022
- 资助金额:
$ 66.55万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
The Study of Reading Picture Books In 5-Year-Old Class and the Support Process of the Teachers
五岁班绘本阅读研究及教师支持过程
- 批准号:
19K14156 - 财政年份:2019
- 资助金额:
$ 66.55万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Improving motor skills in 3-5 year old children with Autism Spectrum Disorder: Effects on the family unit.
提高患有自闭症谱系障碍的 3-5 岁儿童的运动技能:对家庭单位的影响。
- 批准号:
386469 - 财政年份:2017
- 资助金额:
$ 66.55万 - 项目类别:
Studentship Programs
Epidemiological study and Creating new diagnostic methods for Neurodevelopmental disorders in 5-year-old children
5岁儿童神经发育障碍流行病学研究及诊断新方法
- 批准号:
16K10239 - 财政年份:2016
- 资助金额:
$ 66.55万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Differences in motor milestone attainment in 4- and 5-year old children at risk for Developmental Coordination Disorder
有发育协调障碍风险的 4 岁和 5 岁儿童在运动里程碑方面的差异
- 批准号:
324425 - 财政年份:2015
- 资助金额:
$ 66.55万 - 项目类别:
Prevalence and social determinants of developmental outcomes among 5-year-old children with health disorders: A Pan-Canadian study
5 岁儿童健康障碍的患病率和发育结果的社会决定因素:一项泛加拿大研究
- 批准号:
322111 - 财政年份:2015
- 资助金额:
$ 66.55万 - 项目类别:
Operating Grants
Fornative Expressive Behavior in Children's (4 years old and 5 year-old) Artistic Play Activities
儿童(4岁和5岁)艺术游戏活动中的本能表达行为
- 批准号:
26780506 - 财政年份:2014
- 资助金额:
$ 66.55万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
The development which is a shift support program to a 1st grader of elementary school from 5-year old children who prevents "a 1st grade of elementary school, problem"
作为防止"小学一年级、问题"的5岁儿童到小学一年级学生的轮班支援计划的展开
- 批准号:
25381292 - 财政年份:2013
- 资助金额:
$ 66.55万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of behavioural measures of sentence comprehension in 2 to 5 year old children
2至5岁儿童句子理解行为测量的发展
- 批准号:
449402-2013 - 财政年份:2013
- 资助金额:
$ 66.55万 - 项目类别:
University Undergraduate Student Research Awards
Technology development and neuroimaging for 5 year old children with HIV infectio
5 岁 HIV 感染儿童的技术开发和神经影像学
- 批准号:
8333355 - 财政年份:2011
- 资助金额:
$ 66.55万 - 项目类别: