Neural Phenotypes of Females with Autism Spectrum Disorder
患有自闭症谱系障碍的女性的神经表型
基本信息
- 批准号:9248812
- 负责人:
- 金额:$ 66.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-07-10 至 2019-03-31
- 项目状态:已结题
- 来源:
- 关键词:3 year old5 year oldAdolescenceAffectAgeAmygdaloid structureAttenuatedAutistic DisorderAutoantibodiesBehavior assessmentBiologicalBrainBrain regionChildChildhoodComorbidityCopy Number PolymorphismDataDevelopmentDiagnosisDiffusionDiseaseDorsalEnrollmentEnvironmental Risk FactorEtiologyEvaluationFemaleFibrinogenFusiform gyrusGenesGeneticGenetic LoadGoalsGrowthHeterogeneityHigh PrevalenceImageIndividualInstitutesInsulin-Dependent Diabetes MellitusInvestigationLifeMagnetic Resonance ImagingMalignant Childhood NeoplasmMedialMegalencephalyMissionModelingNeuronsNursery SchoolsParticipantPhenotypePrefrontal CortexPrevalenceRecruitment ActivityResearchResearch Domain CriteriaRestSample SizeSamplingSex BiasSex CharacteristicsSex RatioStrategic PlanningStructure of superior temporal sulcusSubgroupSystemTimeUnited StatesUnited States National Institutes of HealthVentral StriatumWomen&aposs HealthWorkagedautism spectrum disorderbehavior testbehavioral outcomeboysbrain abnormalitiescohortcommunication behaviordiffusion weightedgirlshealth differenceleukemiamaleneuropathologyphenomeprogramsprotective effectpublic health relevancerelating to nervous systemrepetitive behaviorresearch studysexsexual dimorphismsocial communicationsocial communication impairmentwhite matter
项目摘要
DESCRIPTION (provided by applicant): Autism spectrum disorder (ASD) affects 1 in 88 children in the United States, but the disorder is much more common in boys than in girls. The prevalence of ASD in boys is 5 times higher than in girls, with a rate of 1 in 54 for boys and 1 in
252 for girls. Although this disparate sex ratio is among the most highly replicated findings in studies of ASD, sex differences in ASD remain poorly understood. The neuropathology of ASD in females is understudied because ASD samples recruited for research studies typically reflect the strong male bias of the disorder. The goal of this study is to evaluate a large, sex-balanced cohort of preschool-aged children with ASD in order to elucidate the neural phenotypes of females with ASD and to identify sex-differences in the neuropathology of ASD. Children will be enrolled at the time of diagnosis (2-3 years of age) and followed longitudinally for two years. Imaging will be carried out at study enrolment and then at two additional annual time points and behavioral testing will be conducted twice, in conjunction with the first and third MRI time points Imaging will include structural, diffusion-weighted and resting state functional connectivity in order to accomplish the following aims: 1) to evaluate sex differences in the neural systems that underlie core deficits in ASD 2) to investigate sex differences in brain growth trajectories in these neural systems and 3) to identify associations between distinct neural phenotypic subgroups and etiologic factors or behavioral outcomes. A comprehensive understanding of the female phenotype of ASD is a pressing and timely topic, as indicated by national efforts to direct research towards this topic. This program of research responds to the Interagency Autism Coordinating Committee (IACC) strategic plan to evaluate females with ASD as well as the mission of the NIH Office of Research on Women's Health to strengthen and enhance research related to diseases, disorders and conditions that affect females.
描述(由申请人提供):自闭症谱系障碍(ASD)影响美国88名儿童中的1名,但这种疾病在男孩中比女孩更常见。ASD在男孩中的患病率是女孩的5倍,男孩的患病率为1/54,
252女孩虽然这种不同的性别比例是ASD研究中重复性最高的发现之一,但ASD的性别差异仍然知之甚少。女性ASD的神经病理学研究不足,因为ASD样本招募的研究通常反映了强烈的男性偏见的疾病。本研究的目的是评估一个大型的,性别平衡的学龄前儿童ASD队列,以阐明女性ASD的神经表型,并确定ASD神经病理学的性别差异。儿童将在诊断时(2-3岁)入组,并纵向随访两年。将在研究入组时进行成像,然后在另外两个年度时间点进行成像,并将在第一个和第三个MRI时间点进行两次行为测试。成像将包括结构、弥散加权和静息状态功能连接,以实现以下目标:1)评估ASD核心缺陷背后的神经系统的性别差异,2)调查这些神经系统中大脑生长轨迹的性别差异,3)以确定不同的神经表型亚群和病因因素或行为结果之间的关联。全面了解ASD的女性表型是一个紧迫而及时的主题,正如国家努力将研究引向这一主题所表明的那样。该研究方案响应了机构间自闭症协调委员会(IACC)评估自闭症女性的战略计划,以及美国国立卫生研究院妇女健康研究办公室的使命,以加强和提高与影响女性的疾病,障碍和状况有关的研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Christine Wu Nordahl其他文献
19.2 SEX DIFFERENCES IN AMYGDALA DEVELOPMENT IN AUTISM SPECTRUM DISORDER FROM EARLY TO MIDDLE CHILDHOOD
- DOI:
10.1016/j.jaac.2021.07.662 - 发表时间:
2021-10-01 - 期刊:
- 影响因子:
- 作者:
Christine Wu Nordahl - 通讯作者:
Christine Wu Nordahl
Correction: Video Game Use, Aggression, and Social Impairment in Adolescents with Autism Spectrum Disorder
- DOI:
10.1007/s10803-022-05694-w - 发表时间:
2022-07-29 - 期刊:
- 影响因子:2.800
- 作者:
Konnor Davis;Ana-Maria Iosif;Christine Wu Nordahl;Marjorie Solomon;Marie K. Krug - 通讯作者:
Marie K. Krug
Sex Differences in the Striatal Contributions to Longitudinal Fine Motor Development in Autistic Children
自闭症儿童纹状体对纵向精细运动发展的性别差异
- DOI:
10.1016/j.biopsych.2025.01.005 - 发表时间:
2025-06-15 - 期刊:
- 影响因子:9.000
- 作者:
Olivia Surgent;Derek S. Andrews;Joshua K. Lee;Joseph Boyle;Andrew Dakopolos;Meghan Miller;Sally Ozonoff;Sally J. Rogers;Marjorie Solomon;David G. Amaral;Christine Wu Nordahl - 通讯作者:
Christine Wu Nordahl
Erratum: Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder
- DOI:
10.1186/s13229-015-0030-3 - 发表时间:
2015-06-20 - 期刊:
- 影响因子:5.500
- 作者:
Christine Wu Nordahl;Ana-Maria Iosif;Gregory S Young;Lee Michael Perry;Robert Dougherty;Aaron Lee;Deana Li;Michael H Buonocore;Tony Simon;Sally Rogers;Brian Wandell;David G Amaral - 通讯作者:
David G Amaral
Christine Wu Nordahl的其他文献
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{{ truncateString('Christine Wu Nordahl', 18)}}的其他基金
Neural and developmental trajectories of females with autism spectrum disorder
患有自闭症谱系障碍的女性的神经和发育轨迹
- 批准号:
10614560 - 财政年份:2022
- 资助金额:
$ 66.55万 - 项目类别:
Neural and developmental trajectories of females with autism spectrum disorder
患有自闭症谱系障碍的女性的神经和发育轨迹
- 批准号:
10443473 - 财政年份:2022
- 资助金额:
$ 66.55万 - 项目类别:
Behavioral and Neurobiological Phenotyping of ASD with Megalencephaly
自闭症谱系障碍(ASD)伴巨脑畸形的行为和神经生物学表型
- 批准号:
10238007 - 财政年份:2017
- 资助金额:
$ 66.55万 - 项目类别:
Neural Phenotypes of Females with Autism Spectrum Disorder
患有自闭症谱系障碍的女性的神经表型
- 批准号:
8749078 - 财政年份:2014
- 资助金额:
$ 66.55万 - 项目类别:
Analyses of Brain Structure and Connectivity in Young Children with Autism
自闭症幼儿的大脑结构和连接性分析
- 批准号:
8519565 - 财政年份:2011
- 资助金额:
$ 66.55万 - 项目类别:
PROTEOMIC PROFILING OF INTEGRAL MEMBRANE PROTEIN TOPOLOGY
整体膜蛋白拓扑结构的蛋白质组学分析
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8365856 - 财政年份:2011
- 资助金额:
$ 66.55万 - 项目类别:
IDENTIFICATION OF HUMAN PROTEINS IN A MOUSE XENOGRAPH MODEL
小鼠异种模型中人类蛋白质的鉴定
- 批准号:
8365848 - 财政年份:2011
- 资助金额:
$ 66.55万 - 项目类别:
Analyses of Brain Structure and Connectivity in Young Children with Autism
自闭症幼儿的大脑结构和连接性分析
- 批准号:
8299854 - 财政年份:2011
- 资助金额:
$ 66.55万 - 项目类别:
Analyses of Brain Structure and Connectivity in Young Children with Autism
自闭症幼儿的大脑结构和连接性分析
- 批准号:
8320314 - 财政年份:2011
- 资助金额:
$ 66.55万 - 项目类别:
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