Houston Area Molecular Biophysics Program

休斯顿地区分子生物物理学计划

• 批准号: 10443569
• 负责人: THEODORE G WENSEL
• 金额: $ 46.83万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-30 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10443569
• 关键词: Area; Biophysics; Molecular; programs

The Houston Area Molecular Biophysics Program (HAMBP) has guided and led research training in molecular biophysics for PhD students in the Houston-Galveston area since 1989. A five-year renewal with one additional slot (10 total) is sought to allow continued excellence and innovation in training outstanding students interested in working at the cutting edges of this increasingly important field. Under the direction of the program director and a steering committee with representatives from each of five graduate schools of the Gulf Coast Consortia (Baylor College of Medicine, Rice University, University of Texas MD Anderson Cancer Center/University of Texas Health Science Center-Houston, University of Texas Medical Branch at Galveston, and University of Houston) the program provides didactic and seminar courses, two local annual research conferences with trainee talks and poster sessions, monthly trainee meetings, professional/career development seminars, attendance at national meetings, and annual presentation and review of trainee research progress. All students are required to participate in training in the responsible conduct of research and workshops in rigor and reproducibility. Mentors include 39 faculty members at six institutions, affiliated with 14 different departments and 4 interdepartmental graduate programs. These faculty have exemplary training and research records, as well as strong research funding. They have trained 191 predocs and 229 postdocs over the past 10 years, and continue to be active, with 106 predocs and 76 postdocs currently in their labs. Our predoctoral trainees will have completed one year of study and have selected a major thesis advisor at one of the participating institutions before joining HAMBP. Trainees are selected in a highly competitive process from students whose projects in mentors' laboratories provide training in molecular biophysics. While trainee selection is based on merit, the program is committed to enhancing diversity and has been very successful in recruiting and retaining members of underrepresented groups. Research strengths include x-ray crystallography, macromolecular NMR, cryo-electron microscopy, a wide range of spectroscopic and microscopic techniques, single molecule methods, computational biophysics, membrane biophysics, protein folding, nucleic acid structure and ultrastructure, thermodynamics, kinetics and mechanistic enzymology. Supported students who complete the program publish an average of 3 papers from their thesis research, including many in high impact journals, and go on to successful, research-focused careers in academia, industry, government agencies, and private organizations. The heavy involvement of institutions of the Texas Medical Center and the University of Texas Medical Branch at Galveston ensures that students are involved in and exposed to research relevant to human health. The quantitative and interdisciplinary skills that are emphasized in the program are critical for advancing biomedical research and making breakthroughs in our understanding of human disease processes and in the design of new therapeutics and diagnostics.

休斯顿地区分子生物物理计划(HAMBP)指导和领导了分子方面的研究培训 自1989年以来，休斯顿-加尔维斯顿地区的博士生生物物理学。与一人续签五年 寻求额外的名额(共10个)，以期在培养优秀学生方面继续保持卓越和创新 有兴趣在这个日益重要的领域的前沿工作。在节目的指导下 主任和一个由墨西哥湾沿岸五所研究生院各自代表组成的指导委员会 联盟(贝勒医学院，莱斯大学，德克萨斯大学MD安德森癌症 中心/德克萨斯大学休斯顿健康科学中心，德克萨斯大学加尔维斯顿医学分校， 和休斯顿大学)该计划提供教学和研讨会课程，两个当地的年度研究 与实习生谈话和海报会议的会议，每月实习生会议，专业/职业 发展研讨会、出席国家会议以及对受训人员的年度介绍和审查 研究进展。所有学生都被要求参加负责任的研究行为培训。 以及关于严谨和可重复性的研讨会。导师包括六个机构的39名教职员工，隶属于 14个不同的系和4个跨系研究生课程。这些教员受过模范训练。 和研究记录，以及强大的研究资金。培养了191名博士后和229名博士后 在过去的10年里，并继续活跃，目前有106名博士后和76名博士后在他们的实验室中。 我们的博士前实习生将完成一年的学习，并在 在加入HAMBP之前是参与机构之一。学员是在竞争激烈的情况下挑选出来的 学生在导师实验室的项目提供分子生物物理学方面的培训。而当 学员的选择是基于功绩的，该计划致力于增强多样性，并一直非常 成功地招募和留住代表性不足群体的成员。研究优势包括x射线 结晶学，大分子核磁共振，低温电子显微镜，广泛的光谱和 显微技术、单分子方法、计算生物物理学、膜生物物理学、蛋白质 折叠、核酸结构和超微结构、热力学、动力学和机械酶学。 完成该项目的受助学生平均发表3篇论文， 包括许多在高影响力期刊上的人，并继续在学术界成功地、专注于研究的职业生涯， 行业、政府机构和私人组织。得克萨斯州各机构的大量参与 医学中心和德克萨斯大学加尔维斯顿分校确保学生参与 并接触到与人类健康相关的研究。量化和跨学科技能是 在该计划中强调的是推进生物医学研究和在我们的 对人类疾病过程的理解以及新疗法和诊断方法的设计。