Houston Area Molecular Biophysics Program

描述（由申请人提供）：休斯顿地区分子生物物理学计划（HAMBP）是一个博士。分子生物物理学研究培训计划，涉及休斯顿-加尔维斯顿地区六个教育/研究机构的43名教师导师：贝勒医学院、莱斯大学、休斯顿大学、德克萨斯大学休斯顿健康科学中心、德克萨斯大学医学博士。安德森癌症中心和德克萨斯大学医学分支在加尔维斯顿。由于这类院校的教职员人数众多，而申请人的类别亦各不相同，因此，我们建议把获资助的受训学生人数维持在9名。学生在教室和实验室进行严格的学习。所有学员需要参加的项目活动包括分子生物物理学教学课程和负责任的研究行为、每周研讨会、每月学员会议、年度研究研讨会和进展审查，以及参加两次年度研究会议并发表演讲。他们在分子生物物理学的基础上获得了坚实的基础，接触了广泛的主题，并在世界一流的生物物理实验室进行尖端的论文研究。研究领域包括X射线晶体学、大分子电子显微镜、荧光、磁共振和其他类型的大分子光谱学、热力学、动力学、分子动力学、理论生物物理学、蛋白质折叠、核酸结构、分子识别等。所研究的生物结构的大小范围从肽和脂质介质到病毒、转录复合物和肌丝。受资助的学员包括5个代表性不足的少数民族，平均GRE成绩为78%（Q），82%（A），74%（V），平均本科GPA为3.50/4.0。在过去10年中支持的29名完成博士学位的学生的平均学位时间是5.27年。每名受训人员的平均出版物数量为3.8，其中包括许多引人注目的论文和期刊封面。校友在完成培训后获得了优秀的职位，并继续在高水平上进行研究。该方案由一个由所有伙伴机构代表组成的指导委员会管理，该委员会密切监测学员的进展情况，并就申请学生和导师的录取作出决定。HAMBP是合作机构的几个非常成功的合作培训和研究企业之一，这些合作机构共同代表了比美国任何单一机构更大的研究资源和受训人员库相关性：分子生物物理学培训使研究事业能够对人类疾病和诊断，治疗和疾病预防创新方法的发展有基本的了解。生物物理学为生物医学研究和医学实践中的所有专业提供了工具

DESCRIPTION (provided by applicant): The Houston Area Molecular Biophysics Program (HAMBP) is a Ph.D. research training program in molecular biophysics involving 43 faculty mentors in six educational/research institutions in the Houston- Galveston area: Baylor College of Medicine, Rice University, University of Houston, University of Texas Health Science Center at Houston, University of Texas M.D. Anderson Cancer Center, and University of Texas Medical Branch at Galveston. Because of the large number of faculty, and the large and diverse applicant pool represented by this group of institutions, we propose to maintain our number of funded trainees at 9. Students pursue a rigorous course of study in the classroom and in the laboratory. Program activities required of all trainees include didactic courses in Molecular Biophysics and responsible conduct of research, a weekly seminar, monthly trainee meetings, an annual research symposium and progress review, and attendance and presentation at two annual research conferences. They receive a strong foundation in the fundamentals-of Molecular Biophysics, with exposure to a broad range of topics, and pursue cutting-edge thesis research in world-class biophysics laboratories. Research areas include x-ray crystallography, macromolecular electron microscopy, fluorescence, magnetic resonance and other types of macromolecular spectroscopy, thermodynamics, kinetics, molecular dynamics, theoretical biophysics, protein folding, nucleic acid structure, molecular recognition, and others. Biological structures studied range in size from peptides and lipid mediators to viruses, transcription complexes, and muscle filaments. Supported trainees have included 5 underrepresented minorities, and have had average GRE scores of 78%tile (Q), 82%tile (A), 74%tile(V), with average undergraduate GPAs of 3.50/4.0. The average time-to-degree of the 29 students supported in the last 10 years who have completed their Ph.D. is 5.27 years. The average number of publications per trainee is 3.8 for graduated trainees, including many high-profile papers and journal covers. Alumni have secured excellent positions upon completion of training, and continue to perform research at a high level. The Program is administered by a Steering Committee of representatives from all partner institutions, which closely monitors the progress of trainees, and make decisions about admission of applicant students and mentors. HAMBP is one of several highly successful cooperative training and research ventures of the partner institutions, which together represent a larger pool of research resources and trainees than any single institution in the U.S. RELEVANCE: Training in Molecular Biophysics enables research careers leading to fundamental understanding of human disease and development of innovative approaches to diagnostics, therapeutics, and disease prevention. Biophysics provides tools used by all specialties in biomedical research and in medical practice